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Outputs (171)

Entomological impact of mass administration of ivermectin and dihydroartemisinin-piperaquine in The Gambia: a cluster-randomized controlled trial (2022)
Journal Article
Soumare, H. M., Dabira, E. D., Camara, M. M., Jadama, L., Gaye, P. M., Kanteh, S., Jawara, E. A., Njie, A. K., Sanneh, F., Ndiath, M. O., Lindsay, S. W., Conteh, B., Ceesay, S., Mohammed, N., Ooko, M., Bradley, J., Drakeley, C., Erhart, A., Bousema, T., & D’Alessandro, U. (2022). Entomological impact of mass administration of ivermectin and dihydroartemisinin-piperaquine in The Gambia: a cluster-randomized controlled trial. Parasites and Vectors, 15(1), https://doi.org/10.1186/s13071-022-05557-4

Background Vector control interventions in sub-Saharan Africa rely on insecticide-treated nets and indoor residual spraying. Insecticide resistance, poor coverage of interventions, poor quality nets and changes in vector behavior threaten the effecti... Read More about Entomological impact of mass administration of ivermectin and dihydroartemisinin-piperaquine in The Gambia: a cluster-randomized controlled trial.

House screening for malaria control: views and experiences of participants in the RooPfs trial (2022)
Journal Article
Jones, C., Matta, A., Pinder, M., D’Alessandro, U., Knudsen, J., & Lindsay, S. W. (2022). House screening for malaria control: views and experiences of participants in the RooPfs trial. Malaria Journal, 21(294), https://doi.org/10.1186/s12936-022-04321-4

Background The housing stock of rural sub-Saharan Africa is changing rapidly. With millions of new homes required over the coming decades, there is an opportunity to protect residents by screening homes from malaria mosquitoes. This study, undertaken... Read More about House screening for malaria control: views and experiences of participants in the RooPfs trial.

Assessing the impact of a novel house design on the incidence of malaria in children in rural Africa: study protocol for a household-cluster randomized controlled superiority trial (2022)
Journal Article
Mshamu, S., Mmbando, A., Meta, J., Bradley, J., Bøjstrup, T. C., Day, N. P., Mukaka, M., Okumu, F., Olotu, A., Pell, C., Deen, J., Knudsen, J., Lindsay, S. W., & von Seidlein, L. (2022). Assessing the impact of a novel house design on the incidence of malaria in children in rural Africa: study protocol for a household-cluster randomized controlled superiority trial. Trials, 23(1), Article 519. https://doi.org/10.1186/s13063-022-06461-z

Background Traditional rural housing in hot, humid regions of sub-Saharan Africa usually consists of single-level, poorly ventilated dwellings. Houses are mostly poorly screened against malaria mosquitoes and limited airflow discourages the use of be... Read More about Assessing the impact of a novel house design on the incidence of malaria in children in rural Africa: study protocol for a household-cluster randomized controlled superiority trial.

Skin microbiome alters attractiveness to Anopheles mosquitoes (2022)
Journal Article
Showering, A., Martinez, J., Benavente, E. D., Gezan, S. A., Jones, R. T., Oke, C., Tytheridge, S., Pretorius, E., Scott, D., Allen, R. L., D’Alessandro, U., Lindsay, S. W., Armour, J. A., Pickett, J., & Logan, J. G. (2022). Skin microbiome alters attractiveness to Anopheles mosquitoes. BMC Microbiology, 22(1), https://doi.org/10.1186/s12866-022-02502-4

Background: Some people produce specifc body odours that make them more attractive than others to mosquitoes, and consequently are at higher risk of contracting vector-borne diseases. The skin microbiome can break down carbohydrates, fatty acids and... Read More about Skin microbiome alters attractiveness to Anopheles mosquitoes.

Using trained dogs and organic semi-conducting sensors to identify asymptomatic and mild SARS-CoV-2 infections: an observational study (2022)
Journal Article
Guest, C., Dewhirst, S. Y., Lindsay, S. W., Allen, D. J., Aziz, S., Baerenbold, O., Bradley, J., Chabildas, U., Chen-Hussey, V., Clifford, S., Cottis, L., Dennehy, J., Foley, E., Gezan, S. A., Gibson, T., Greaves, C. K., Kleinschmidt, I., Lambert, S., Last, A., Morant, S., …Davis, J. (2022). Using trained dogs and organic semi-conducting sensors to identify asymptomatic and mild SARS-CoV-2 infections: an observational study. Journal of Travel Medicine, 29(3), Article taac043. https://doi.org/10.1093/jtm/taac043

Background A rapid, accurate, non-invasive diagnostic screen is needed to identify people with SARS-CoV-2 infection. We investigated whether organic semi-conducting (OSC) sensors and trained dogs could distinguish between people infected with asympto... Read More about Using trained dogs and organic semi-conducting sensors to identify asymptomatic and mild SARS-CoV-2 infections: an observational study.

House design and risk of malaria, acute respiratory infection and gastrointestinal illness in Uganda: A cohort study (2022)
Journal Article
Musiime, A. K., Krezanoski, P. J., Smith, D. L., Kilama, M., Conrad, M. D., Otto, G., Kyagamba, P., Asiimwe, J., Rek, J., Nankabirwa, J. I., Arinaitwe, E., Akol, A. M., Kamya, M. R., Staedke, S. G., Drakeley, C., Bousema, T., Lindsay, S. W., Dorsey, G., & Tusting, L. S. (2022). House design and risk of malaria, acute respiratory infection and gastrointestinal illness in Uganda: A cohort study. PLOS Global Public Health, 2(3), https://doi.org/10.1371/journal.pgph.0000063

The durability, functionality and acceptability of novel screened doors and windows after 4 years of use in a Gambian village: a cross-sectional survey (2022)
Journal Article
Shenton, F. C., Jawara, M., Carrasco-Tenezaca, M., Knudsen, J., D’Alessandro, U., & Lindsay, S. W. (2022). The durability, functionality and acceptability of novel screened doors and windows after 4 years of use in a Gambian village: a cross-sectional survey. Malaria Journal, 21(1), https://doi.org/10.1186/s12936-022-04087-9

Background The World Health Organization recommends house screening as a tool for malaria control, yet evidence of the long-term durability, functionality and acceptability of this intervention is lacking. In this study, the sustainability and use of... Read More about The durability, functionality and acceptability of novel screened doors and windows after 4 years of use in a Gambian village: a cross-sectional survey.

The effect of light and ventilation on house entry by Anopheles arabiensis sampled using light traps in Tanzania: an experimental hut study (2022)
Journal Article
Mmbando, A. S., Bradley, J., Kazimbaya, D., Kasubiri, R., Knudsen, J., Siria, D., von Seidlein, L., Okumu, F. O., & Lindsay, S. W. (2022). The effect of light and ventilation on house entry by Anopheles arabiensis sampled using light traps in Tanzania: an experimental hut study. Malaria Journal, 21(1), https://doi.org/10.1186/s12936-022-04063-3

Background In sub-Saharan Africa, house design and ventilation affects the number of malaria mosquito vectors entering houses. This study hypothesized that indoor light from a CDC-light trap, visible from outside a hut, would increase entry of Anophe... Read More about The effect of light and ventilation on house entry by Anopheles arabiensis sampled using light traps in Tanzania: an experimental hut study.

Risk of Plasmodium falciparum infection in south-west Burkina Faso: potential impact of expanding eligibility for seasonal malaria chemoprevention (2022)
Journal Article
Yaro, J. B., Tiono, A. B., Ouedraogo, A., Lambert, B., Ouedraogo, Z. A., Diarra, A., Traore, A., Lankouande, M., Soulama, I., Sanou, A., Worrall, E., Agboraw, E., Sagnon, N., Ranson, H., Churcher, T. S., Lindsay, S. W., & Wilson, A. L. (2022). Risk of Plasmodium falciparum infection in south-west Burkina Faso: potential impact of expanding eligibility for seasonal malaria chemoprevention. Scientific Reports, 12(1), Article 1402. https://doi.org/10.1038/s41598-022-05056-7

Burkina Faso has one of the highest malaria burdens in sub-Saharan Africa despite the mass deployment of insecticide-treated nets (ITNs) and use of seasonal malaria chemoprevention (SMC) in children aged up to 5 years. Identification of risk factors... Read More about Risk of Plasmodium falciparum infection in south-west Burkina Faso: potential impact of expanding eligibility for seasonal malaria chemoprevention.

Mass drug administration of ivermectin and dihydroartemisinin–piperaquine against malaria in settings with high coverage of standard control interventions: a cluster-randomised controlled trial in The Gambia (2021)
Journal Article
Dabira, E. D., Soumare, H. M., Conteh, B., Ceesay, F., Ndiath, M. O., Bradley, J., Mohammed, N., Kandeh, B., Smit, M. R., Slater, H., Peeters Grietens, K., Broekhuizen, H., Bousema, T., Drakeley, C., Lindsay, S. W., Achan, J., & D'Alessandro, U. (2022). Mass drug administration of ivermectin and dihydroartemisinin–piperaquine against malaria in settings with high coverage of standard control interventions: a cluster-randomised controlled trial in The Gambia. The Lancet Infectious Diseases, 22(4), 519-528. https://doi.org/10.1016/s1473-3099%2821%2900557-0

Background: Although the malaria burden has substantially decreased in sub-Saharan Africa, progress has stalled. We assessed whether mass administration of ivermectin (a mosquitocidal drug) and dihydroartemisinin–piperaquine (an antimalarial treatmen... Read More about Mass drug administration of ivermectin and dihydroartemisinin–piperaquine against malaria in settings with high coverage of standard control interventions: a cluster-randomised controlled trial in The Gambia.

Effect of roof colour on indoor temperature and human comfort levels, with implications for malaria control: a pilot study using experimental houses in rural Gambia (2021)
Journal Article
Carrasco-Tenezaca, M., Jatta, E., Jawara, M., Bradley, J., Pinder, M., D’Alessandro, U., Knudsen, J., & Lindsay, S. W. (2021). Effect of roof colour on indoor temperature and human comfort levels, with implications for malaria control: a pilot study using experimental houses in rural Gambia. Malaria Journal, 20(1), Article 423. https://doi.org/10.1186/s12936-021-03951-4

Background In rural sub-Saharan Africa, thatch roofs are being replaced by metal roofs. Metal roofing, however, increases indoor temperatures above human comfort levels, and thus makes it more likely that residents will not use an insecticide-treated... Read More about Effect of roof colour on indoor temperature and human comfort levels, with implications for malaria control: a pilot study using experimental houses in rural Gambia.

Estimating intervention effectiveness in trials of malaria interventions with contamination (2021)
Journal Article
Multerer, L., Vanobberghen, F., Glass, T. R., Hiscox, A., Lindsay, S. W., Takken, W., Tiono, A., & Smith, T. (2021). Estimating intervention effectiveness in trials of malaria interventions with contamination. Malaria Journal, 20(1), Article 413. https://doi.org/10.1186/s12936-021-03924-7

Background: In cluster randomized trials (CRTs) or stepped wedge cluster randomized trials (SWCRTs) of malaria interventions, mosquito movement leads to contamination between trial arms unless bufer zones separate the clusters. Contamination can be a... Read More about Estimating intervention effectiveness in trials of malaria interventions with contamination.

Risk factors associated with house entry of malaria vectors in an area of Burkina Faso with high, persistent malaria transmission and high insecticide resistance (2021)
Journal Article
Yaro, J. B., Tiono, A. B., Sanou, A., Toe, H. K., Bradley, J., Ouedraogo, A., Ouedraogo, Z. A., Guelbeogo, M. W., Agboraw, E., Worrall, E., Sagnon, N., Lindsay, S. W., & Wilson, A. L. (2021). Risk factors associated with house entry of malaria vectors in an area of Burkina Faso with high, persistent malaria transmission and high insecticide resistance. Malaria Journal, 20(1), Article 397. https://doi.org/10.1186/s12936-021-03926-5

Background In rural Burkina Faso, the primary malaria vector Anopheles gambiae sensu lato (s.l.) primarily feeds indoors at night. Identification of factors which influence mosquito house entry could lead to development of novel malaria vector contro... Read More about Risk factors associated with house entry of malaria vectors in an area of Burkina Faso with high, persistent malaria transmission and high insecticide resistance.

Risk factors for Plasmodium falciparum infection in pregnant women in Burkina Faso: a community-based cross-sectional survey (2021)
Journal Article
Yaro, J. B., Ouedraogo, A., Diarra, A., Sombié, S., Ouedraogo, Z. A., Nébié, I., Drakeley, C., Sirima, S. B., Tiono, A. B., Lindsay, S. W., & Wilson, A. L. (2021). Risk factors for Plasmodium falciparum infection in pregnant women in Burkina Faso: a community-based cross-sectional survey. Malaria Journal, 20(1), Article 362. https://doi.org/10.1186/s12936-021-03896-8

Background: Malaria in pregnancy remains a public health problem in sub-Saharan Africa. Identifying risk factors for malaria in pregnancy could assist in developing interventions to reduce the risk of malaria in Burkina Faso and other countries in th... Read More about Risk factors for Plasmodium falciparum infection in pregnant women in Burkina Faso: a community-based cross-sectional survey.

Threats to the effectiveness of insecticide-treated bednets for malaria control: thinking beyond insecticide resistance (2021)
Journal Article
Lindsay, S. W., Thomas, M. B., & Kleinschmidt, I. (2021). Threats to the effectiveness of insecticide-treated bednets for malaria control: thinking beyond insecticide resistance. The Lancet Global Health, 9(9), e1325-e1331. https://doi.org/10.1016/s2214-109x%2821%2900216-3

From 2004 to 2019, insecticide-treated bednets (ITNs) have been the most effective tool for reducing malaria morbidity and mortality in sub-Saharan Africa. Recently, however, the decline in malaria cases and deaths has stalled. Some suggest that this... Read More about Threats to the effectiveness of insecticide-treated bednets for malaria control: thinking beyond insecticide resistance.

Pyriproxyfen-treated bed nets reduce reproductive fitness and longevity of pyrethroid-resistant Anopheles gambiae under laboratory and field conditions (2021)
Journal Article
Grisales, N., Lees, R. S., Maas, J., Morgan, J. C., Wangrawa, D. W., Guelbeogo, W. M., N’Fale, S., Lindsay, S. W., McCall, P. J., & Ranson, H. (2021). Pyriproxyfen-treated bed nets reduce reproductive fitness and longevity of pyrethroid-resistant Anopheles gambiae under laboratory and field conditions. Malaria Journal, 20(1), Article 273. https://doi.org/10.1186/s12936-021-03794-z

Background: The efficacy of insecticide-treated nets (ITNs) containing the insect growth regulator pyriproxyfen (PPF) and pyrethroid insecticides (PPF-ITNs) is being assessed in clinical trials to determine whether they provide greater protection fro... Read More about Pyriproxyfen-treated bed nets reduce reproductive fitness and longevity of pyrethroid-resistant Anopheles gambiae under laboratory and field conditions.

The relationship between house height and mosquito house entry: an experimental study in rural Gambia (2021)
Journal Article
Carrasco-Tenezaca, M., Jawara, M., Abdi, M. Y., Bradley, J., Brittain, O. S., Ceesay, S., D'Alessandro, U., Jeffries, D., Pinder, M., Wood, H., Knudsen, J. B., & Lindsay, S. W. (2021). The relationship between house height and mosquito house entry: an experimental study in rural Gambia. Journal of the Royal Society. Interface, 18(178), Article 20210256. https://doi.org/10.1098/rsif.2021.0256

Most malaria infections in sub-Saharan Africa are acquired indoors, thus finding effective ways of preventing mosquito house entry should reduce transmission. Since most malaria mosquitoes fly less than 1 m from the ground, we tested whether raising... Read More about The relationship between house height and mosquito house entry: an experimental study in rural Gambia.

Impact of increased ventilation on indoor temperature and malaria mosquito density: an experimental study in The Gambia (2021)
Journal Article
Jatta, E., Carrasco-Tenezaca, M., Jawara, M., Bradley, J., Ceesay, S., D'Alessandro, U., Jeffries, D., Kandeh, B., Lee, D. S.-H., Pinder, M., Wilson, A. L., Knudsen, J., & Lindsay, S. W. (2021). Impact of increased ventilation on indoor temperature and malaria mosquito density: an experimental study in The Gambia. Journal of the Royal Society. Interface, 18(178), Article 20201030. https://doi.org/10.1098/rsif.2020.1030

In sub-Saharan Africa, cooler houses would increase the coverage of insecticide-treated bednets, the primary malaria control tool. We examined whether improved ventilation, using windows screened with netting, cools houses at night and reduces malari... Read More about Impact of increased ventilation on indoor temperature and malaria mosquito density: an experimental study in The Gambia.

Improved housing versus usual practice for additional protection against clinical malaria in The Gambia (RooPfs): a household-randomised controlled trial (2021)
Journal Article
Pinder, M., Bradley, J., Jawara, M., Affara, M., Conteh, L., Correa, S., Jeffries, D., Jones, C., Kandeh, B., Knudsen, J., Olatunji, Y., Sicuri, E., D'Alessandro, U., & Lindsay, S. W. (2021). Improved housing versus usual practice for additional protection against clinical malaria in The Gambia (RooPfs): a household-randomised controlled trial. The Lancet Planetary Health, 5(4), e220-e229. https://doi.org/10.1016/s2542-5196%2821%2900002-4

Background In malaria-endemic areas, residents of modern houses have less malaria than those living in traditional houses. We aimed to assess whether children in The Gambia received an incremental benefit from improved housing, where current best pra... Read More about Improved housing versus usual practice for additional protection against clinical malaria in The Gambia (RooPfs): a household-randomised controlled trial.