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HFO-1234yf as a CF3-building block: Synthesis and Chemistry of CF­3-ynones (2020)
Journal Article
Murray, B. J., Marsh, T. G., Yufit, D. S., Fox, M. A., Harsanyi, A., Boulton, L. T., & Sandford, G. (2020). HFO-1234yf as a CF3-building block: Synthesis and Chemistry of CF­3-ynones. European Journal of Organic Chemistry, 2020(39), 6236-6244. https://doi.org/10.1002/ejoc.202001071

Reaction of low cost, readily available 4th generation refrigerant gas 2,3,3,3‐tetrafluoropropene (HFO‐1234yf) with lithium diisopropylamide (LDA) leads to formation of lithium 3,3,3‐trifluoropropynide, addition of which to a range of aldehydes forme... Read More about HFO-1234yf as a CF3-building block: Synthesis and Chemistry of CF­3-ynones.

a-Fluorotricarbonyl derivatives as versatile fluorinated building blocks: synthesis of fluoro-acetophenone, fluoro-ketoester and fluoro-pyran-4-one derivatives (2020)
Journal Article
Harsanyi, A., Luckener, A., Pasztor, H., Yilmaz, Z., Tam, L., Yufit, D., & Sandford, G. (2020). a-Fluorotricarbonyl derivatives as versatile fluorinated building blocks: synthesis of fluoro-acetophenone, fluoro-ketoester and fluoro-pyran-4-one derivatives. European Journal of Organic Chemistry, 2020(25), 3872-3878. https://doi.org/10.1002/ejoc.202000503

Fluorinated acyl‐Meldrum’s acid derivatives were synthesised by electrophilic fluorination of appropriate phenacyl Meldrum’s acid substrates using Selectfluor. Reactions with water, ethanol, Grignard and alkynyl lithium reagents gave rise to the corr... Read More about a-Fluorotricarbonyl derivatives as versatile fluorinated building blocks: synthesis of fluoro-acetophenone, fluoro-ketoester and fluoro-pyran-4-one derivatives.

Tetrahydropyrido 3,4-b pyrazine scaffolds from pentafluoropyridine (2005)
Journal Article
Sandford, G., Slater, R., Yufit, D., Howard, J., & Vong, A. (2005). Tetrahydropyrido 3,4-b pyrazine scaffolds from pentafluoropyridine. Journal of Organic Chemistry, 70(18), 7208-7216. https://doi.org/10.1021/jo0508696

Representative polyfunctional tetrahydropyrido[3,4-b]pyrazine scaffolds have been synthesized very readily by a one-pot annelation reaction of pentafluoropyridine with appropriate diamines. The trifluorinated pyridopyrazine products react sequentiall... Read More about Tetrahydropyrido 3,4-b pyrazine scaffolds from pentafluoropyridine.