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Heterogeneous ketonic decarboxylation of dodecanoic acid: studying reaction parameters (2021)
Journal Article
Perera-Solis, D. D., Zholobenko, V. L., Whiting, A., & Greenwell, H. C. (2021). Heterogeneous ketonic decarboxylation of dodecanoic acid: studying reaction parameters. RSC Advances, 11(56), https://doi.org/10.1039/d1ra06871g

Ketonic decarboxylation has gained significant attention in recent years as a pathway to reduce the oxygen content within biomass-derived oils, and to produce sustainable ketones. The reaction is base catalysed, with MgO an economic, accessible and h... Read More about Heterogeneous ketonic decarboxylation of dodecanoic acid: studying reaction parameters.

Structure-functional relationship of cellular retinoic acid binding proteins I and II interacting with natural and synthetic ligands (2021)
Journal Article
Tomlinson, C. W., Cornish, K. A., Whiting, A., & Pohl, E. (2021). Structure-functional relationship of cellular retinoic acid binding proteins I and II interacting with natural and synthetic ligands. Acta Crystallographica Section D: Structural Biology, 77(2), 164-175. https://doi.org/10.1107/s2059798320015247

A detailed understanding of the interactions between small-molecule ligands and their proposed binding targets is of the utmost importance for modern drug-development programs. Cellular retinoic acid-binding proteins I and II (CRABPI and CRABPII) fac... Read More about Structure-functional relationship of cellular retinoic acid binding proteins I and II interacting with natural and synthetic ligands.

Adding Value to Waste Minerals in a Circular Economy Framework: Ochre-Derived Layered Double Hydroxide Catalysts in Fatty Acid Ketonisation (2019)
Journal Article
Perera-Solis, D. D., Pimlott, M., Fidment, E., Whiting, A., & Greenwell, H. C. (2019). Adding Value to Waste Minerals in a Circular Economy Framework: Ochre-Derived Layered Double Hydroxide Catalysts in Fatty Acid Ketonisation. Minerals, 9(11), Article 681. https://doi.org/10.3390/min9110681

Mineral carbonation is known to be among the most efficient ways to reduce the anthropogenic emissions of carbon dioxide. Serpentine minerals (Mg3Si2O5(OH)4), have shown great potential for carbonation. A way to improve yield is to thermally activate... Read More about Adding Value to Waste Minerals in a Circular Economy Framework: Ochre-Derived Layered Double Hydroxide Catalysts in Fatty Acid Ketonisation.

Reduced to hierarchy: carbon filament supported mixed metal oxide nanoparticles (2019)
Journal Article
Manohara, G. V., Whiting, A., & Greenwell, C. (2019). Reduced to hierarchy: carbon filament supported mixed metal oxide nanoparticles. ACS Omega, 4(23), 20230-20236. https://doi.org/10.1021/acsomega.9b02534

We describe a one-pot synthesis method for carbon filament-supported mixed metal oxide nanoparticles. The thermal intracrystalline reaction of adamantanecarboxylate ions confined inside interlayer galleries of layered double hydroxide materials under... Read More about Reduced to hierarchy: carbon filament supported mixed metal oxide nanoparticles.

Fluorescent retinoic acid analogues as probes for biochemical and intracellular characterization of retinoid signalling pathways (2019)
Journal Article
Chisholm, D., Tomlinson, C., Zhou, G., Holden, C., Affleck, V., Lamb, R., …Pohl, E. (2019). Fluorescent retinoic acid analogues as probes for biochemical and intracellular characterization of retinoid signalling pathways. ACS Chemical Biology, 14(3), 369-377. https://doi.org/10.1021/acschembio.8b00916

Retinoids, such as all-trans-retinoic acid (ATRA), are endogenous signalling molecules derived from Vitamin A that influ-ence a variety of cellular processes through mediation of transcription events in the cell nucleus. Due to these wide-ranging and... Read More about Fluorescent retinoic acid analogues as probes for biochemical and intracellular characterization of retinoid signalling pathways.

A novel fluorescence competition assay for retinoic acid binding proteins (2018)
Journal Article
Tomlinson, C. W., Chisholm, D. R., Valentine, R., Whiting, A., & Pohl, E. (2018). A novel fluorescence competition assay for retinoic acid binding proteins. ACS Medicinal Chemistry Letters, 9(12), 1297–1300-1300. https://doi.org/10.1021/acsmedchemlett.8b00420

Vitamin A derived retinoid compounds have multiple, powerful roles in the cellular growth and development cycle, and as a result have attracted significant attention from both academic and pharmaceutical research in developing and characterizing synt... Read More about A novel fluorescence competition assay for retinoic acid binding proteins.

Approaches to Styrenyl Building Blocks for the Synthesis of Polyene Xanthomonadin and its Analogues (2018)
Journal Article
Madden, K., Laroche, B., David, S., Batsanov, A., Thompson, D., Knowles, J., & Whiting, A. (2018). Approaches to Styrenyl Building Blocks for the Synthesis of Polyene Xanthomonadin and its Analogues. European Journal of Organic Chemistry, 2018(38), 5312-5322. https://doi.org/10.1002/ejoc.201800540

A number of aryl building blocks for the synthesis of two xanthomonadin natural product pigments, as well as a related analogue, were accessed using a divergent hydroboration/bromoboration approach from a key alkynyl intermediate. A new approach towa... Read More about Approaches to Styrenyl Building Blocks for the Synthesis of Polyene Xanthomonadin and its Analogues.

The molecular basis of the interactions between synthetic retinoic acid analogues and the retinoic acid receptors (2017)
Journal Article
Haffez, H., Chisholm, D., Valentine, R., Pohl, E., Redfern, C., & Whiting, A. (2017). The molecular basis of the interactions between synthetic retinoic acid analogues and the retinoic acid receptors. MedChemComm, 8(3), 578-592. https://doi.org/10.1039/c6md00680a

All-trans-retinoic acid (ATRA) and its synthetic analogues EC23 and EC19 direct cellular differentiation by interacting as ligands for the retinoic acid receptor (RARα, β and γ) family of nuclear receptor proteins. To date, a number of crystal struct... Read More about The molecular basis of the interactions between synthetic retinoic acid analogues and the retinoic acid receptors.

Practical synthetic strategies towards lipophilic 6-iodotetrahydroquinolines and -dihydroquinolines (2016)
Journal Article
Chisholm, D., Zhou, G., Pohl, E., Valentine, R., & Whiting, A. (2016). Practical synthetic strategies towards lipophilic 6-iodotetrahydroquinolines and -dihydroquinolines. Beilstein Journal of Organic Chemistry, 12, 1851-1862. https://doi.org/10.3762/bjoc.12.174

The synthesis of novel tetrahydroquinolines (THQ) and dihydroquinolines (DHQ) are reported using three practical, scalable synthetic approaches to access highly lipophilic analogues bearing a 6-iodo substituent, each with a different means of cyclisa... Read More about Practical synthetic strategies towards lipophilic 6-iodotetrahydroquinolines and -dihydroquinolines.

Conjugate Addition of 3-Buytn-2-one to Anilines in Ethanol: Alkene Geometric Insights through In Situ FTIR Monitoring (2016)
Journal Article
Chisholm, D. R., Valentine, R., Pohl, E., & Whiting, A. (2016). Conjugate Addition of 3-Buytn-2-one to Anilines in Ethanol: Alkene Geometric Insights through In Situ FTIR Monitoring. Journal of Organic Chemistry, 81(17), 7557-7565. https://doi.org/10.1021/acs.joc.6b01110

A convenient, mild and effective conjugate addition of 3-butyn-2-one to a variety of anilines in ethanol is reported. The reaction was monitored and characterized through in situ FTIR, and the dynamics of the facile E/Z alkene geometry interconversio... Read More about Conjugate Addition of 3-Buytn-2-one to Anilines in Ethanol: Alkene Geometric Insights through In Situ FTIR Monitoring.

Bis(2,6-dimethylpyridyl)iodonium dibromoiodate (2006)
Journal Article
Batsanov, A., Lightfoot, A., Twiddle, S., & Whiting, A. (2006). Bis(2,6-dimethylpyridyl)iodonium dibromoiodate. Acta crystallographica. Section E, E62, o901-o902. https://doi.org/10.1107/s1600536806003680

The crystal structure of the title compound, C14H18IN2+·Br2I-, isostructural with the Cl2I analogue, comprises discrete centrosymmetric cations and anions, both with linear coordination of the I atoms.

N-(diphenylphosphinoyl)hydroxylamine. (2006)
Journal Article
Blatch, A., Howard, J., Probert, M., & Whiting, A. (2006). N-(diphenylphosphinoyl)hydroxylamine. Acta crystallographica. Section E, 62(11), o5343-o5345. https://doi.org/10.1107/s1600536806044862

The title compound, C12H12NO2P, is the first structurally studied phospho­rus hydroxy­lamine derivative. The N atom is pyramidal. In the crystal structure, hydrogen bonds link mol­ecules into double ribbons.

tert-Butyl N-(phosphino­yloxy)carbamate. (2006)
Journal Article
Blatch, A., Howard, J., Probert, M., Smethurst, C., & Whiting, A. (2006). tert-Butyl N-(phosphino­yloxy)carbamate. Acta crystallographica. Section E, 62(11), o5346-o5348. https://doi.org/10.1107/s1600536806044783

The title compound, C17H20NO4P, contains pyramidal N atoms and adopts similar conformations in its three independent mol­ecules (A, B and C). Mol­ecules A and B form a dimer in the crystal structure by way of a pair of N-H...O hydrogen bonds, as does... Read More about tert-Butyl N-(phosphino­yloxy)carbamate..

Synthesis and structure of potential Lewis acid-Lewis base bifunctional catalysts: 2-N,N-diisopropylaminophenylboronate derivatives (2005)
Journal Article
Coghlan, S., Giles, R., Howard, J., Patrick, L., Probert, M., Smith, G., & Whiting, A. (2005). Synthesis and structure of potential Lewis acid-Lewis base bifunctional catalysts: 2-N,N-diisopropylaminophenylboronate derivatives. Journal of Organometallic Chemistry, 690(21-22), 4784-4793

Directed ortho-metallation is used to introduce a boron function into N,N-diisopropylbenzamide,. resulting in the formation of both borinate and boronate derivatives. N,N-Diisopropylbenzamide ortho-boronate pinacol ester can be reduced with sodium bo... Read More about Synthesis and structure of potential Lewis acid-Lewis base bifunctional catalysts: 2-N,N-diisopropylaminophenylboronate derivatives.

Interlayer structure and bonding in nonswelling primary amine intercalated clays (2005)
Journal Article
Greenwell, H., Harvey, M., Boulet, P., Bowden, A., Coveney, P., & Whiting, A. (2005). Interlayer structure and bonding in nonswelling primary amine intercalated clays. Macromolecules, 38(14), 6189-6200. https://doi.org/10.1021/ma0503817

Preparation of industrially useful clay-polymer nanocomposite materials often requires the dispersal of clay particles within a polymer matrix. The degree to which the clay particles may be dispersed has an effect on the resultant properties of the m... Read More about Interlayer structure and bonding in nonswelling primary amine intercalated clays.

Mechanistic studies on the formal aza-Diels-Alder reactions of N-aryl imines: evidence for the non-concertedness under Lewis-acid catalysed conditions (2004)
Journal Article
Hermitage, S., Howard, J., Jay, D., Pritchard, R., Probert, M., & Whiting, A. (2004). Mechanistic studies on the formal aza-Diels-Alder reactions of N-aryl imines: evidence for the non-concertedness under Lewis-acid catalysed conditions. Organic and Biomolecular Chemistry, 2(17), 2451-2460. https://doi.org/10.1039/b407293f

The reaction of a para-methoxyaniline, ethyl glyoxalate-derived imine with a series of dienes has resulted in products, which initially suggest the operation of different modes of aza-Diels-Alder reaction. However, a more likely explanation is that a... Read More about Mechanistic studies on the formal aza-Diels-Alder reactions of N-aryl imines: evidence for the non-concertedness under Lewis-acid catalysed conditions.

Synthesis and structure of potential Lewis acid-Lewis base bifunctional catalysts: 1-N,N-dimethylamino-8-borononaphthalene derivatives (2003)
Journal Article
Giles, R., Howard, J., Patrick, L., Probert, M., Smith, G., & Whiting, A. (2003). Synthesis and structure of potential Lewis acid-Lewis base bifunctional catalysts: 1-N,N-dimethylamino-8-borononaphthalene derivatives. Journal of Organometallic Chemistry, 680(1-2), 257-262

A new series of boronate-amine substituted potential bifunctional catalysts have been prepared by directed lithiation of 1-N,N-dimethylnaphthalene, followed by reaction borate esters. Both diisopropyl and pincacol ester derivatives of the resulting b... Read More about Synthesis and structure of potential Lewis acid-Lewis base bifunctional catalysts: 1-N,N-dimethylamino-8-borononaphthalene derivatives.

p-Tolylsulfonyl cyanide (2002)
Journal Article
Jay, D., Whiting, A., Yufit, D., Howard, J., & Hermitage, S. (2002). p-Tolylsulfonyl cyanide. Acta crystallographica. Section B, Structural science, 58, o191-o193

The first crystal structure of a sulfonyl cyanide, C8H7NO2S, has been determined. The molecule has an unusual bond-length distribution, with a very long S-Csp bond [1.772 (2) Angstrom] and a short S-Csp(2) bond [1.7368 (17) Angstrom].