Enolization rates control mono- versus di-fluorination of 1,3-dicarbonyl derivatives
(2019)
Journal Article
Rozatian, N., Beeby, A., Ashworth, I. W., Sandford, G., & Hodgson, D. R. (2019). Enolization rates control mono- versus di-fluorination of 1,3-dicarbonyl derivatives. Chemical Science, 10(44), 10318-10330. https://doi.org/10.1039/c9sc04185k
Fluorine-containing 1,3-dicarbonyl derivatives are essential building blocks for drug discovery and manufacture. To understand the factors that determine selectivity between mono- and di-fluorination of 1,3-dicarbonyls systems, we have performed kine... Read More about Enolization rates control mono- versus di-fluorination of 1,3-dicarbonyl derivatives.