GOF Mutant p53 in Cancers: A Therapeutic Challenge
(2022)
Journal Article
Lobsang, D., & Muller, P. A. (2022). GOF Mutant p53 in Cancers: A Therapeutic Challenge. Cancers, 14(20), Article 5091. https://doi.org/10.3390/cancers14205091
TP53 is mutated in the majority of human cancers. Mutations can lead to loss of p53 expression or expression of mutant versions of the p53 protein. These mutant p53 proteins have oncogenic potential. They can inhibit any remaining WTp53 in a dominant... Read More about GOF Mutant p53 in Cancers: A Therapeutic Challenge.