Insoluble Aβ overexpression in an App knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, and impacts on anxiety-related behaviours
(2019)
Journal Article
Pervolaraki, E., Hall, S., Foresteire, D., Saito, T., Saido, T., Whittington, M., …Dachtler, J. (2019). Insoluble Aβ overexpression in an App knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, and impacts on anxiety-related behaviours. Disease Models and Mechanisms, 12(9), Article dmm040550. https://doi.org/10.1242/dmm.040550
We studied a new App knock-in mice model of Alzheimer’s disease (AppNL-G-F), containing the Swedish KM670/671NL mutation, the Iberian I716F mutation and the Artic E693G mutation, which generates elevated levels of Aβ40 and Aβ42 without the confounds... Read More about Insoluble Aβ overexpression in an App knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, and impacts on anxiety-related behaviours.