Integrated Stochastic Model of DNA Damage Repair by Non-homologous End Joining and p53/p21- Mediated Early Senescence Signalling
(2015)
Journal Article
Dolan, D. W., Zupanic, A., Nelson, G., Hall, P., Miwa, S., Kirkwood, T. B., & Shanley, D. P. (2015). Integrated Stochastic Model of DNA Damage Repair by Non-homologous End Joining and p53/p21- Mediated Early Senescence Signalling. PLoS Computational Biology, 11(5), Article e1004246. https://doi.org/10.1371/journal.pcbi.1004246
Unrepaired or inaccurately repaired DNA damage can lead to a range of cell fates, such as apoptosis, cellular senescence or cancer, depending on the efficiency and accuracy of DNA damage repair and on the downstream DNA damage signalling. DNA damage... Read More about Integrated Stochastic Model of DNA Damage Repair by Non-homologous End Joining and p53/p21- Mediated Early Senescence Signalling.