Dr Brian Suarez Mantilla's Outputs (2)

Metabolomic profiling reveals a finely tuned, starvation-induced metabolic switch in Trypanosoma cruziepimastigotes (2017)
Journal Article
Barisón, M. J., Rapado, L. N., Merino, E. F., Furusho Pral, E. M., Mantilla, B. S., Marchese, L., Nowicki, C., Silber, A. M., & Cassera, M. B. (2017). Metabolomic profiling reveals a finely tuned, starvation-induced metabolic switch in Trypanosoma cruziepimastigotes. Journal of Biological Chemistry, 292(21), 8964-8977. https://doi.org/10.1074/jbc.m117.778522

Trypanosoma cruzi, the etiological agent of Chagas disease, is a protozoan parasite with a complex life cycle involving a triatomine insect and mammals. Throughout its life cycle, the T. cruzi parasite faces several alternating events of cell divisio... Read More about Metabolomic profiling reveals a finely tuned, starvation-induced metabolic switch in Trypanosoma cruziepimastigotes.

Proline Metabolism is Essential for Trypanosoma brucei brucei Survival in the Tsetse Vector (2017)
Journal Article
Mantilla, B. S., Marchese, L., Casas-Sánchez, A., Dyer, N. A., Ejeh, N., Biran, M., Bringaud, F., Lehane, M. J., Acosta-Serrano, A., & Silber, A. M. (2017). Proline Metabolism is Essential for Trypanosoma brucei brucei Survival in the Tsetse Vector. PLoS Pathogens, 13(1), Article e1006158. https://doi.org/10.1371/journal.ppat.1006158

Adaptation to different nutritional environments is essential for life cycle completion by all Trypanosoma brucei sub-species. In the tsetse fly vector, L-proline is among the most abundant amino acids and is mainly used by the fly for lactation and... Read More about Proline Metabolism is Essential for Trypanosoma brucei brucei Survival in the Tsetse Vector.