Directed Remote Lateral Metalation: Highly Substituted 2-Naphthols and BINOLs by In Situ Generation of a Directing Group
(2018)
Journal Article
Patel, J. J., Laars, M., Gan, W., Board, J., Kitching, M. O., & Snieckus, V. (2018). Directed Remote Lateral Metalation: Highly Substituted 2-Naphthols and BINOLs by In Situ Generation of a Directing Group. Angewandte Chemie International Edition, 57(30), 9425-9429. https://doi.org/10.1002/anie.201805203
A general synthesis of highly substituted 2‐naphthols based on a new carbanionic reaction sequence is demonstrated. The reaction exploits the dual nature of lithium bases consisting of consecutive ring opening of readily available coumarins with eith... Read More about Directed Remote Lateral Metalation: Highly Substituted 2-Naphthols and BINOLs by In Situ Generation of a Directing Group.