Skip to main content

Research Repository

Advanced Search

Dr Matthew Kitching's Outputs (5)

A Flow-Based Synthesis of 2-Aminoadamantane-2-carboxylic Acid (2012)
Journal Article
Battilocchio, C., Baxendale, I. R., Biava, M., Kitching, M. O., & Ley, S. V. (2012). A Flow-Based Synthesis of 2-Aminoadamantane-2-carboxylic Acid. Organic Process Research and Development, 16(5), 798-810. https://doi.org/10.1021/op300084z

The development of a new, high-yielding, scalable and safe process for the preparation of 2-aminoadamantane-2-carboxylic acid (1) is described. This geminal, functionalized achiral amino acid has been reported to possess interesting biological activi... Read More about A Flow-Based Synthesis of 2-Aminoadamantane-2-carboxylic Acid.

Scale-Up of Flow-Assisted Synthesis of C-2-Symmetric Chiral PyBox Ligands (2012)
Journal Article
Battilocchio, C., Baumann, M., Baxendale, I. R., Biava, M., Kitching, M. O., Ley, S. V., …Tappin, N. D. (2012). Scale-Up of Flow-Assisted Synthesis of C-2-Symmetric Chiral PyBox Ligands. Synthesis: Journal of Synthetic Organic Chemistry, 44(4), 635-647. https://doi.org/10.1055/s-0031-1289676

A series of PyBox ligands were prepared from commercially available chelidonic acid by a multistep flow sequence using mesoreactor technology. A chloro group introduced onto the ligand scaffold was subsequently exploited to give amine derivatives rea... Read More about Scale-Up of Flow-Assisted Synthesis of C-2-Symmetric Chiral PyBox Ligands.