Dr Will Brittain's Outputs (3)

Synthesis of Complex Unnatural Fluorine-Containing Amino Acids (2020)
Journal Article
Brittain, W. D., Lloyd, C. M., & Cobb, S. L. (2020). Synthesis of Complex Unnatural Fluorine-Containing Amino Acids. Journal of Fluorine Chemistry, 239, Article 109630. https://doi.org/10.1016/j.jfluchem.2020.109630

The area of fluorinated amino acid synthesis has seen rapid growth over the past decade. As reports of singly fluorinated natural amino acid derivatives have grown, researchers have turned their attention to develop methodology to access complex prot... Read More about Synthesis of Complex Unnatural Fluorine-Containing Amino Acids.

Protecting Group Controlled Remote Regioselective Electrophilic Aromatic Halogenation Reactions (2020)
Journal Article
Brittain, W. D. G., & Cobb, S. L. (2020). Protecting Group Controlled Remote Regioselective Electrophilic Aromatic Halogenation Reactions. Journal of Organic Chemistry, 85(11), 6862-6871. https://doi.org/10.1021/acs.joc.9b03322

Being able to utilise a protecting group to influence remote regiocontrol offers a simple alternative approach to direct late-stage functionalisation of complex organic molecules. However, protecting groups that have the ability to influence reaction... Read More about Protecting Group Controlled Remote Regioselective Electrophilic Aromatic Halogenation Reactions.

N-Terminal speciation for native chemical ligation (2020)
Journal Article
Maguire, O. R., Zhu, J., Brittain, W. D., Hudson, A. S., Cobb, S. L., & O’Donoghue, A. C. (2020). N-Terminal speciation for native chemical ligation. Chemical Communications, 56(45), 6114-6117. https://doi.org/10.1039/d0cc01604g

Native chemical ligation (NCL) enables the chemical synthesis of peptides via reactions between N-terminal thiolates and C-terminal thioesters under mild, aqueous conditions at pH 7–8. Here we demonstrate quantitatively how thiol speciation at N-term... Read More about N-Terminal speciation for native chemical ligation.