Dr James Walton's Outputs (2)

As nice as π: aromatic reactions activated by π‐coordination to transition metals (2020)
Journal Article
Williams, L. J., Bhonoah, Y., Wilkinson, L. A., & Walton, J. W. (2021). As nice as π: aromatic reactions activated by π‐coordination to transition metals. Chemistry - A European Journal, 27(11), 3650-3660. https://doi.org/10.1002/chem.202004621

π‐Coordination of aromatic molecules to metals dramatically alters their reactivity. For example, coordinated carbons become more electrophilic and C‐H bonds of coordinated rings become more acidic. For many years, this change in reactivity has been... Read More about As nice as π: aromatic reactions activated by π‐coordination to transition metals.

Anticancer Ruthenium Complexes with HDAC Isoform Selectivity (2020)
Journal Article
Cross, J., Blower, T., Kingdon, A., Pal, R., Picton, D., & Walton, J. (2020). Anticancer Ruthenium Complexes with HDAC Isoform Selectivity. Molecules, 25(10), Article 2383. https://doi.org/10.3390/molecules25102383

The histone deacetylase (HDAC) enzymes have emerged as an important class of molecular targets in cancer therapy, with five inhibitors in clinical use. Recently, it has been shown that a lack of selectivity between the 11 Zn-dependent HDAC isoforms m... Read More about Anticancer Ruthenium Complexes with HDAC Isoform Selectivity.