Dr Karrera Djoko's Outputs (5)

Mis-regulation of Zn and Mn homeostasis is a key phenotype of Cu stress in Streptococcus pyogenes. (2023)
Journal Article
Hong, Y., Mackenzie, E. S., Firth, S. J., Bolton, J. R. F., Stewart, L. J., Waldron, K. J., & Djoko, K. Y. (2023). Mis-regulation of Zn and Mn homeostasis is a key phenotype of Cu stress in Streptococcus pyogenes. Metallomics, 15(11), Article mfad064. https://doi.org/10.1093/mtomcs/mfad064

All bacteria possess homeostastic mechanisms that control the availability of micronutrient metals within the cell. Cross-talks between different metal homeostasis pathways within the same bacterial organism have been reported widely. In addition, th... Read More about Mis-regulation of Zn and Mn homeostasis is a key phenotype of Cu stress in Streptococcus pyogenes..

Structural and biochemical characterisation of the N‐carbamoyl‐β‐alanine amidohydrolase from Rhizobium radiobacterMDC 8606 (2023)
Journal Article
Paloyan, A., Sargsyan, A., Karapetyan, M. D., Hambardzumyan, A., Kocharov, S., Panosyan, H., Dyukova, K., Kinosyan, M., Krueger, A., Piergentili, C., Stanley, W. A., Djoko, K. Y., Baslé, A., Marles‐Wright, J., & Antranikian, G. (2023). Structural and biochemical characterisation of the N‐carbamoyl‐β‐alanine amidohydrolase from Rhizobium radiobacterMDC 8606. The FEBS Journal, 290(23), 5566-5580. https://doi.org/10.1111/febs.16943

N-carbamoyl-β-alanine amidohydrolase (CβAA) constitutes one of the most important groups of industrially relevant enzymes used in the production of optically pure amino acids and derivatives. In this study, a CβAA-encoding gene from Rhizobium radioba... Read More about Structural and biochemical characterisation of the N‐carbamoyl‐β‐alanine amidohydrolase from Rhizobium radiobacterMDC 8606.

Control of nutrient metal availability during host-microbe interactions: beyond nutritional immunity (2023)
Journal Article
Djoko, K. Y. (2023). Control of nutrient metal availability during host-microbe interactions: beyond nutritional immunity. JBIC Journal of Biological Inorganic Chemistry, 28(5), 451-456. https://doi.org/10.1007/s00775-023-02007-z

The control of nutrient availability is an essential ecological function of the host organism in host-microbe systems. Although often overshadowed by macronutrients such as carbohydrates, micronutrient metals are known as key drivers of host-microbe... Read More about Control of nutrient metal availability during host-microbe interactions: beyond nutritional immunity.

The Synergy between Zinc and Antimicrobial Peptides: An Insight into Unique Bioinorganic Interactions (2023)
Journal Article
Donaghy, C., Javellana, J. G., Hong, Y.-J., Djoko, K., & Angeles-Boza, A. M. (2023). The Synergy between Zinc and Antimicrobial Peptides: An Insight into Unique Bioinorganic Interactions. Molecules, 28(5), Article 2156. https://doi.org/10.3390/molecules28052156

Antimicrobial peptides (AMPs) are essential components of innate immunity across all species. AMPs have become the focus of attention in recent years, as scientists are addressing antibiotic resistance, a public health crisis that has reached epidemi... Read More about The Synergy between Zinc and Antimicrobial Peptides: An Insight into Unique Bioinorganic Interactions.

Salivary Antimicrobial Peptide Histatin-5 Does Not Display Zn(II)-Dependent or -Independent Activity against Streptococci (2023)
Journal Article
Stewart, L. J., Hong, Y., Holmes, I. R., Firth, S. J., Ahmed, Y., Quinn, J., Santos, Y., Cobb, S. L., Jakubovics, N. S., & Djoko, K. Y. (2023). Salivary Antimicrobial Peptide Histatin-5 Does Not Display Zn(II)-Dependent or -Independent Activity against Streptococci. ACS Infectious Diseases, 9(3), 631-642. https://doi.org/10.1021/acsinfecdis.2c00578

Histatin-5 (Hst5) is a member of the histatin superfamily of cationic, His-rich, Zn(II)-binding peptides in human saliva. Hst5 displays antimicrobial activity against fungal and bacterial pathogens, often in a Zn(II)-dependent manner. In contrast, he... Read More about Salivary Antimicrobial Peptide Histatin-5 Does Not Display Zn(II)-Dependent or -Independent Activity against Streptococci.