Dr Karrera Djoko's Outputs (2)

Structural basis of thiol-based regulation of formaldehyde detoxification in H. influenzae by a MerR regulator with no sensor region (2016)
Journal Article
Couñago, R. M., Chen, N. H., Chang, C., Djoko, K. Y., McEwan, A. G., & Kobe, B. (2016). Structural basis of thiol-based regulation of formaldehyde detoxification in H. influenzae by a MerR regulator with no sensor region. Nucleic Acids Research, 44(14), 6981-6993. https://doi.org/10.1093/nar/gkw543

Pathogenic bacteria such as Haemophilus influenzae, a major cause of lower respiratory tract diseases, must cope with a range of electrophiles generated in the host or by endogenous metabolism. Formaldehyde is one such compound that can irreversibly... Read More about Structural basis of thiol-based regulation of formaldehyde detoxification in H. influenzae by a MerR regulator with no sensor region.

Formaldehyde Stress Responses in Bacterial Pathogens (2016)
Journal Article
Chen, N. H., Djoko, K. Y., Veyrier, F. J., & McEwan, A. G. (2016). Formaldehyde Stress Responses in Bacterial Pathogens. Frontiers in Microbiology, 7, Article 257. https://doi.org/10.3389/fmicb.2016.00257

Formaldehyde is the simplest of all aldehydes and is highly cytotoxic. Its use and associated dangers from environmental exposure have been well documented. Detoxification systems for formaldehyde are found throughout the biological world and they ar... Read More about Formaldehyde Stress Responses in Bacterial Pathogens.