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Dr Karrera Djoko's Outputs (3)

Inhibition of respiratory Complex I by copper(ii)-bis(thiosemicarbazonato) complexes (2014)
Journal Article
Djoko, K. Y., Donnelly, P. S., & McEwan, A. G. (2014). Inhibition of respiratory Complex I by copper(ii)-bis(thiosemicarbazonato) complexes. Metallomics, 6(12), 2250-2259. https://doi.org/10.1039/c4mt00226a

Several copper(II) complexes of bis(thiosemicarbazones) [Cu(btsc)s] show promise as therapeutics for the treatment of neurological diseases, cancers and bacterial infections. These complexes are thought to act primarily as copper ionophores or “coppe... Read More about Inhibition of respiratory Complex I by copper(ii)-bis(thiosemicarbazonato) complexes.

A Role for Lactate Dehydrogenases in the Survival of Neisseria gonorrhoeae in Human Polymorphonuclear Leukocytes and Cervical Epithelial Cells (2014)
Journal Article
Atack, J. M., Ibranovic, I., Ong, C. Y., Djoko, K. Y., Chen, N. H., vanden Hoven, R., …McEwan, A. G. (2014). A Role for Lactate Dehydrogenases in the Survival of Neisseria gonorrhoeae in Human Polymorphonuclear Leukocytes and Cervical Epithelial Cells. The Journal of Infectious Diseases, 210(8), 1311-1318. https://doi.org/10.1093/infdis/jiu230

Lactate is an abundant metabolite, produced by host tissues and commensal organisms, and it represents an important potential carbon source for bacterial pathogens. In the case of Neisseria spp., the importance of the lactate permease in colonization... Read More about A Role for Lactate Dehydrogenases in the Survival of Neisseria gonorrhoeae in Human Polymorphonuclear Leukocytes and Cervical Epithelial Cells.

Antimicrobial effects of copper(II) bis(thiosemicarbazonato) complexes provide new insight into their biochemical mode of action (2014)
Journal Article
Djoko, K. Y., Paterson, B. M., Donnelly, P. S., & McEwan, A. G. (2014). Antimicrobial effects of copper(II) bis(thiosemicarbazonato) complexes provide new insight into their biochemical mode of action. Metallomics, 6(4), 854-863. https://doi.org/10.1039/c3mt00348e

The copper(II) complexes of bis-thiosemicarbazones (Cu(btsc)) such as Cu(atsm) and Cu(gtsm) are neutral, lipophilic compounds that show promise as therapeutics for the treatment of certain neurological diseases and cancers. Although the effects of th... Read More about Antimicrobial effects of copper(II) bis(thiosemicarbazonato) complexes provide new insight into their biochemical mode of action.