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Dr Karrera Djoko's Outputs (4)

Copper Cytotoxicity: Cellular Casualties of Noncognate Coordination Chemistry (2022)
Journal Article
O’Hern, C. I., & Djoko, K. Y. (2022). Copper Cytotoxicity: Cellular Casualties of Noncognate Coordination Chemistry. mBio, 13(3), e00434-22. https://doi.org/10.1128/mbio.00434-22

Copper (Cu) is an essential micronutrient for cells, but in excess it is cytotoxic. How Cu is cytotoxic is the subject of recent work by L. Zuily, N. Lahrach, R. Fassler, O. Genest, et al. (mBio 13:e03251-21, 2022, https://doi.org/10.1128/mbio.03251-... Read More about Copper Cytotoxicity: Cellular Casualties of Noncognate Coordination Chemistry.

Streptococcus pyogenes Hijacks Host Glutathione for Growth and Innate Immune Evasion (2022)
Journal Article
Brouwer, S., Jespersen, M. G., Ong, C.-L. Y., De Oliveira, D. M., Keller, B., Cork, A. J., Djoko, K. Y., Davies, M. R., & Walker, M. J. (2022). Streptococcus pyogenes Hijacks Host Glutathione for Growth and Innate Immune Evasion. mBio, 13(3), https://doi.org/10.1128/mbio.00676-22

The nasopharynx and the skin are the major oxygen-rich anatomical sites for colonization by the human pathogen Streptococcus pyogenes (group A Streptococcus [GAS]). To establish infection, GAS must survive oxidative stress generated during aerobic me... Read More about Streptococcus pyogenes Hijacks Host Glutathione for Growth and Innate Immune Evasion.

The suppressor of copper sensitivity protein C from Caulobacter crescentus is a trimeric disulfide isomerase that binds copper(I) with subpicomolar affinity (2022)
Journal Article
Petit, G. A., Hong, Y., Djoko, K. Y., Whitten, A. E., Furlong, E. J., McCoy, A. J., Gulbis, J. M., Totsika, M., Martin, J. L., & Halili, M. A. (2022). The suppressor of copper sensitivity protein C from Caulobacter crescentus is a trimeric disulfide isomerase that binds copper(I) with subpicomolar affinity. Acta Crystallographica Section D: Structural Biology, 78(3), https://doi.org/10.1107/s2059798322000729

The introduction of disulfide bonds into periplasmic proteins is a critical process in many Gram-negative bacteria. The formation and regulation of protein disulfide bonds have been linked to the production of virulence factors. Understanding the dif... Read More about The suppressor of copper sensitivity protein C from Caulobacter crescentus is a trimeric disulfide isomerase that binds copper(I) with subpicomolar affinity.