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Professor Sushma Grellscheid's Outputs (29)

The splicing landscape is globally reprogrammed during male meiosis (2013)
Journal Article
Schmid, R., Grellscheid, S., Ehrmann, I., Dalgliesh, C., Danilenko, M., Paronetto, M., …Elliott, D. (2013). The splicing landscape is globally reprogrammed during male meiosis. Nucleic Acids Research, 41(22), 10170-10184. https://doi.org/10.1093/nar/gkt811

Meiosis requires conserved transcriptional changes, but it is not known whether there is a corresponding set of RNA splicing switches. Here, we used RNAseq of mouse testis to identify changes associated with the progression from mitotic spermatogonia... Read More about The splicing landscape is globally reprogrammed during male meiosis.

Identification of novel androgen-regulated pathways and mRNA isoforms through genome-wide exon-specific profiling of the LNCaP transcriptome (2011)
Journal Article
Rajan, P., Dalgliesh, C., Carling, P., Buist, T., Zhang, C., Grellscheid, S., …Elliott, D. (2011). Identification of novel androgen-regulated pathways and mRNA isoforms through genome-wide exon-specific profiling of the LNCaP transcriptome. PLoS ONE, 6(12), Article e29088. https://doi.org/10.1371/journal.pone.0029088

Androgens drive the onset and progression of prostate cancer (PCa) by modulating androgen receptor (AR) transcriptional activity. Although several microarray-based studies have identified androgen-regulated genes, here we identify in-parallel global... Read More about Identification of novel androgen-regulated pathways and mRNA isoforms through genome-wide exon-specific profiling of the LNCaP transcriptome.

Molecular design of a splicing switch responsive to the RNA binding protein Tra2β (2011)
Journal Article
Grellscheid, S., Dalgliesh, C., Rozanska, A., Grellscheid, D., Bourgeois, C., Stévenin, J., & Elliott, D. (2011). Molecular design of a splicing switch responsive to the RNA binding protein Tra2β. Nucleic Acids Research, 39(18), 8092-8104. https://doi.org/10.1093/nar/gkr495

Tra2β regulates a number of splicing switches including activation of the human testis-specific exon HIPK3-T in the Homeodomain Interacting Protein Kinase 3 gene. By testing HIPK3-T exons of different intrinsic strengths, we found Tra2β most efficien... Read More about Molecular design of a splicing switch responsive to the RNA binding protein Tra2β.

The testis-specific human protein RBMY recognizes RNA through a novel mode of interaction. (2007)
Journal Article
Skrisovska, L., Bourgeois, C., Stefl, R., Grellscheid, S., Kister, L., Wenter, P., …Allain, F. (2007). The testis-specific human protein RBMY recognizes RNA through a novel mode of interaction. EMBO Reports, 8(4), 372-379. https://doi.org/10.1038/sj.embor.7400910

The RBMY (RNA‐binding motif gene on Y chromosome) protein encoded by the human Y chromosome is important for normal sperm development. Although its precise molecular RNA targets are unknown at present, it is suggested that human RBMY (hRBMY) particip... Read More about The testis-specific human protein RBMY recognizes RNA through a novel mode of interaction..