Outputs (4)

Space in the brain: how the hippocampal formation supports spatial cognition (2013)
Journal Article
Hartley, T., Lever, C., Burgess, N., & O'Keefe, J. (2014). Space in the brain: how the hippocampal formation supports spatial cognition. Philosophical Transactions of the Royal Society B: Biological Sciences, 369(1635), Article 20120510. https://doi.org/10.1098/rstb.2012.0510

Over the past four decades, research has revealed that cells in the hippocampal formation provide an exquisitely detailed representation of an animal's current location and heading. These findings have provided the foundations for a growing understan... Read More about Space in the brain: how the hippocampal formation supports spatial cognition.

How environment geometry affects grid cell symmetry and what we can learn from it (2013)
Journal Article
Krupic, J., Bauza, M., Burton, S., Lever, C., & O'Keefe, J. (2014). How environment geometry affects grid cell symmetry and what we can learn from it. Philosophical Transactions of the Royal Society B: Biological Sciences, 369(1635), Article 20130188. https://doi.org/10.1098/rstb.2013.0188

The mammalian hippocampal formation provides neuronal representations of environmental location but the underlying mechanisms are unclear. The majority of cells in medial entorhinal cortex and parasubiculum show spatially periodic firing patterns. Gr... Read More about How environment geometry affects grid cell symmetry and what we can learn from it.

Novelty and anxiolytic drugs dissociate two components of hippocampal theta in behaving rats (2013)
Journal Article
Wells, C., Amos, D., Jeewajee, A., Douchamps, V., Rodgers, R., O’Keefe, J., …Lever, C. (2013). Novelty and anxiolytic drugs dissociate two components of hippocampal theta in behaving rats. Journal of Neuroscience, 33(20), 8650-8667. https://doi.org/10.1523/jneurosci.5040-12.2013

Hippocampal processing is strongly implicated in both spatial cognition and anxiety and is temporally organized by the theta rhythm. However, there has been little attempt to understand how each type of processing relates to the other in behaving ani... Read More about Novelty and anxiolytic drugs dissociate two components of hippocampal theta in behaving rats.

Evidence for encoding versus retrieval scheduling in the hippocampus by theta phase and acetylcholine (2013)
Journal Article
Douchamps, V., Jeewajee, A., Blundell, P., Burgess, N., & Lever, C. (2013). Evidence for encoding versus retrieval scheduling in the hippocampus by theta phase and acetylcholine. Journal of Neuroscience, 33(20), 8689-8704. https://doi.org/10.1523/jneurosci.4483-12.2013

The formation of new memories requires new information to be encoded in the face of proactive interference from the past. Two solutions have been proposed for hippocampal region CA1: (1) acetylcholine, released in novelty, selectively suppresses exci... Read More about Evidence for encoding versus retrieval scheduling in the hippocampus by theta phase and acetylcholine.