Andrew Whiting's Outputs (122)

Synthetic Retinoids for the Modulation of Genomic and Nongenomic Processes in Neurodegenerative Diseases (2025)
Journal Article
Butler, A. M., Chisholm, D. R., Tomlinson, C. W., Khatib, T., Clark, J., Wan, S., Coveney, P. V., Greig, I. R., McCaffery, P., Pohl, E., & Whiting, A. (online). Synthetic Retinoids for the Modulation of Genomic and Nongenomic Processes in Neurodegenerative Diseases. ACS Omega, https://doi.org/10.1021/acsomega.5c00934

Retinoids, such as all-trans retinoic acid (ATRA), are the active metabolite forms of endogenous Vitamin A and function as key signaling molecules involved in the regulation of a variety of cellular processes. Due to their highly diverse biological r... Read More about Synthetic Retinoids for the Modulation of Genomic and Nongenomic Processes in Neurodegenerative Diseases.

A Comparative Study of a Potent CNS-Permeable RARβ-Modulator, Ellorarxine, in Neurons, Glia and Microglia Cells In Vitro (2025)
Journal Article
Zhang, Y., Gailloud, L., Shin, A., Fewkes, J., Pinckney, R., Whiting, A., & Chazot, P. (2025). A Comparative Study of a Potent CNS-Permeable RARβ-Modulator, Ellorarxine, in Neurons, Glia and Microglia Cells In Vitro. International Journal of Molecular Sciences, 26(8), 3551. https://doi.org/10.3390/ijms26083551

Vitamin A (retinol) and its derivatives (retinoids) assume critical roles in neural development, cellular differentiation, axon elongation, programmed cell apoptosis and various fundamental cellular processes. Retinoids function by binding to specifi... Read More about A Comparative Study of a Potent CNS-Permeable RARβ-Modulator, Ellorarxine, in Neurons, Glia and Microglia Cells In Vitro.

Borate-catalysed direct amidation reactions of coordinating substrates (2025)
Journal Article
Procter, R. J., Alamillo-Ferrer, C., Shabbir, U., Britton, P., Bučar, D.-K., Dumon, A. S., Rzepa, H. S., Burés, J., Whiting, A., & Sheppard, T. D. (2025). Borate-catalysed direct amidation reactions of coordinating substrates. Chemical Science, https://doi.org/10.1039/d4sc07744j

The catalytic activity of different classes of boron catalysts was studied in amidation reactions with 4-phenylbutylamine/benzoic acid, and with 2-aminopyridine/phenylacetic acid. Whilst a simple boronic acid catalyst showed high catalytic activity w... Read More about Borate-catalysed direct amidation reactions of coordinating substrates.

Neuroprotective effects of ellorarxine in neuronal models of degeneration (2024)
Journal Article
Kouchmeshky, A., Whiting, A., & McCaffery, P. (2024). Neuroprotective effects of ellorarxine in neuronal models of degeneration. Frontiers in Neuroscience, 18, Article 1422294. https://doi.org/10.3389/fnins.2024.1422294

Introduction: Retinoic acid (RA) was first recognised to be important for the central nervous system (CNS) in its developmental regulatory role and, given this action, it has been proposed in the adult CNS to regulate plasticity and promote regenerat... Read More about Neuroprotective effects of ellorarxine in neuronal models of degeneration.

Evaluation of a Synthetic Retinoid, Ellorarxine, in the NSC-34 Cell Model of Motor Neuron Disease (2024)
Journal Article
Escudier, O., Zhang, Y., Whiting, A., & Chazot, P. (2024). Evaluation of a Synthetic Retinoid, Ellorarxine, in the NSC-34 Cell Model of Motor Neuron Disease. International Journal of Molecular Sciences, 25(18), Article 9764. https://doi.org/10.3390/ijms25189764

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease worldwide and is characterized by progressive muscle atrophy. There are currently two approved treatments, but they only relieve symptoms briefly and do not cure the disease.... Read More about Evaluation of a Synthetic Retinoid, Ellorarxine, in the NSC-34 Cell Model of Motor Neuron Disease.

The antibacterial activity of a photoactivatable diarylacetylene against Gram-positive bacteria (2023)
Journal Article
Waite, R., Adams, C. T., Chisholm, D. R., Sims, C. H. C., Hughes, J. G., Dias, E., …Ambler, C. A. (2023). The antibacterial activity of a photoactivatable diarylacetylene against Gram-positive bacteria. Frontiers in Microbiology, 14, Article 1243818. https://doi.org/10.3389/fmicb.2023.1243818

The emergence of antibiotic resistance is a growing threat to human health, and therefore, alternatives to existing compounds are urgently needed. In this context, a novel fluorescent photoactivatable diarylacetylene has been identified and character... Read More about The antibacterial activity of a photoactivatable diarylacetylene against Gram-positive bacteria.

Bullseye Analysis: A Fluorescence Microscopy Technique to Detect Local Changes in Intracellular Reactive Oxygen Species (ROS) Production (2022)
Journal Article
Hughes, J. G., Chisholm, D. R., Whiting, A., Girkin, J. M., & Ambler, C. A. (2023). Bullseye Analysis: A Fluorescence Microscopy Technique to Detect Local Changes in Intracellular Reactive Oxygen Species (ROS) Production. Microscopy and Microanalysis, 29(2), 529-539. https://doi.org/10.1093/micmic/ozac040

Reactive oxygen species (ROS) are naturally produced compounds that play important roles in cell signaling, gene regulation, and biological defense, including involvement in the oxidative burst that is central to the anti-microbial actions of macroph... Read More about Bullseye Analysis: A Fluorescence Microscopy Technique to Detect Local Changes in Intracellular Reactive Oxygen Species (ROS) Production.

A computational tool to accurately and quickly predict 19F NMR chemical shifts of molecules with fluorine–carbon and fluorine–boron bonds (2022)
Journal Article
Dumon, A. S., Rzepa, H. S., Alamillo-Ferrer, C., Bures, J., Procter, R., Sheppard, T. D., & Whiting, A. (2022). A computational tool to accurately and quickly predict 19F NMR chemical shifts of molecules with fluorine–carbon and fluorine–boron bonds. Physical Chemistry Chemical Physics, 24(34), 20409 - 20425. https://doi.org/10.1039/d2cp02317b

We report the evaluation of density-functional-theory (DFT) based procedures for predicting 19F NMR chemical shifts at modest computational cost for a range of molecules with fluorine bonds, to be used as a tool for assisting the characterisation of... Read More about A computational tool to accurately and quickly predict 19F NMR chemical shifts of molecules with fluorine–carbon and fluorine–boron bonds.

Synthetic Diphenylacetylene-Based Retinoids Induce DNA Damage in Chinese Hamster Ovary Cells without Altering Viability (2022)
Journal Article
Hudhud, L., Chisholm, D. R., Whiting, A., Steib, A., Pohóczky, K., Kecskés, A., Szőke, É., & Helyes, Z. (2022). Synthetic Diphenylacetylene-Based Retinoids Induce DNA Damage in Chinese Hamster Ovary Cells without Altering Viability. Molecules, 27(3), Article 977. https://doi.org/10.3390/molecules27030977

All-trans-retinoic acid (ATRA), the active metabolite of vitamin A, plays a pivotal role in cell differentiation, proliferation and embryonic development. It is an effective therapy for dermatological disorders and malignancies. ATRA is prone to isom... Read More about Synthetic Diphenylacetylene-Based Retinoids Induce DNA Damage in Chinese Hamster Ovary Cells without Altering Viability.

Cu@CuCl-visible light co-catalysed chlorination of C(sp3)–H bonds with MCln solution and photocatalytic serial reactor-based synthesis of benzyl chloride (2021)
Journal Article
Zhang, Q., Liu, S., Tian, X., Liu, Y., Fan, S., Huang, B., & Whiting, A. (2022). Cu@CuCl-visible light co-catalysed chlorination of C(sp3)–H bonds with MCln solution and photocatalytic serial reactor-based synthesis of benzyl chloride. Green Chemistry, 24(1), 384-393. https://doi.org/10.1039/d1gc03092b

A highly selective, green and sustainable chlorination of aliphatic C–H bonds is reported using MCln under the co-catalysis of visible light and nano-Cu@CuCl, which was synthesised via a one-step, hydrothermal strategy using copper(II) sulfate and D-... Read More about Cu@CuCl-visible light co-catalysed chlorination of C(sp3)–H bonds with MCln solution and photocatalytic serial reactor-based synthesis of benzyl chloride.

A Bifunctional B,N-Based Asymmetric Catalytic Nitrostyrene-Michael Addition Acting through a 10-Membered Ring Cyclic Transition State (2021)
Journal Article
Du, Y., Sari, O., Erdem, S. S., & Whiting, A. (2021). A Bifunctional B,N-Based Asymmetric Catalytic Nitrostyrene-Michael Addition Acting through a 10-Membered Ring Cyclic Transition State. Helvetica Chimica Acta, 104(12), Article e2100199. https://doi.org/10.1002/hlca.202100199

The B,N-bifunctional catalyst homoboroproline has been applied to a catalytic asymmetric nitroalkene-Michael addition to β-nitrostyrene analogues, showing broad substrate tolerance, high conversions and moderate to good asymmetric induction. The abil... Read More about A Bifunctional B,N-Based Asymmetric Catalytic Nitrostyrene-Michael Addition Acting through a 10-Membered Ring Cyclic Transition State.

Copper(II)-catalyzed aerobic oxidation of hydrazides to azo intermediates and their Diels–Alder versus ene trapping (2021)
Journal Article
Chaiyaveij, D., & Whiting, A. (2021). Copper(II)-catalyzed aerobic oxidation of hydrazides to azo intermediates and their Diels–Alder versus ene trapping. ARKIVOC, 2021(10), 64-76. https://doi.org/10.24820/ark.5550190.p011.606

The oxidation of diethyl 1,2-hydrazinedicarboxylate using a catalytic Cu(II)-oxazoline system occurs at RT in air, resulting in azo generation, which can then be trapped in situ via hetero-Diels-Alder (HDA) and competitive ene-reactions, with chemose... Read More about Copper(II)-catalyzed aerobic oxidation of hydrazides to azo intermediates and their Diels–Alder versus ene trapping.

Heterogeneous ketonic decarboxylation of dodecanoic acid: studying reaction parameters (2021)
Journal Article
Perera-Solis, D. D., Zholobenko, V. L., Whiting, A., & Greenwell, H. C. (2021). Heterogeneous ketonic decarboxylation of dodecanoic acid: studying reaction parameters. RSC Advances, 11(56), https://doi.org/10.1039/d1ra06871g

Ketonic decarboxylation has gained significant attention in recent years as a pathway to reduce the oxygen content within biomass-derived oils, and to produce sustainable ketones. The reaction is base catalysed, with MgO an economic, accessible and h... Read More about Heterogeneous ketonic decarboxylation of dodecanoic acid: studying reaction parameters.

Structure-functional relationship of cellular retinoic acid binding proteins I and II interacting with natural and synthetic ligands (2021)
Journal Article
Tomlinson, C. W., Cornish, K. A., Whiting, A., & Pohl, E. (2021). Structure-functional relationship of cellular retinoic acid binding proteins I and II interacting with natural and synthetic ligands. Acta Crystallographica Section D: Structural Biology, 77(2), 164-175. https://doi.org/10.1107/s2059798320015247

A detailed understanding of the interactions between small-molecule ligands and their proposed binding targets is of the utmost importance for modern drug-development programs. Cellular retinoic acid-binding proteins I and II (CRABPI and CRABPII) fac... Read More about Structure-functional relationship of cellular retinoic acid binding proteins I and II interacting with natural and synthetic ligands.

Cellular localisation of structurally diverse diphenylacetylene fluorophores (2020)
Journal Article
Chisholm, D. R., Hughes, J. G., Blacker, T. S., Humann, R., Adams, C., Callaghan, D., Pujol, A., Lembicz, N. K., Bain, A. J., Girkin, J. M., Ambler, C. A., & Whiting, A. (2020). Cellular localisation of structurally diverse diphenylacetylene fluorophores. Organic and Biomolecular Chemistry, 18(45), 9231-9245. https://doi.org/10.1039/d0ob01153c

Fluorescent probes are increasingly used as reporter molecules in a wide variety of biophysical experiments, but when designing new compounds it can often be difficult to anticipate the effect that changing chemical structure can have on cellular loc... Read More about Cellular localisation of structurally diverse diphenylacetylene fluorophores.

Detection and Time-Tracking Activation of a Photosensitiser on Live Single Colorectal Cancer Cells Using Raman Spectroscopy (2020)
Journal Article
Gala De Pablo, J., Chisholm, D., Ambler, C., Peyman, S., Whiting, A., & Evans, S. (2020). Detection and Time-Tracking Activation of a Photosensitiser on Live Single Colorectal Cancer Cells Using Raman Spectroscopy. Analyst, 145(17), 5878-5888. https://doi.org/10.1039/d0an01023e

Raman spectroscopy has been used to observe uptake, metabolism and response of single-cells to drugs. Photodynamic therapy is based on the use of light, a photosensitiser and oxygen to destroy tumour tissue. Here, we used single-cell Raman spectrosco... Read More about Detection and Time-Tracking Activation of a Photosensitiser on Live Single Colorectal Cancer Cells Using Raman Spectroscopy.

Generating Skeletal Diversity and Complexity from Boron-Substituted 1,3-Dienes and Enophiles (2020)
Journal Article
François, B., Eberlin, L., Berrée, F., Whiting, A., & Carboni, B. (2020). Generating Skeletal Diversity and Complexity from Boron-Substituted 1,3-Dienes and Enophiles. European Journal of Organic Chemistry, 2020(22), 3282-3293. https://doi.org/10.1002/ejoc.202000330

Boron‐substituted 1,3‐dienes participate in ene reactions to afford new functionalized synthetic intermediates. After evaluating several enophiles as partners, the resulting products have been engaged in multistep sequences involving first a Diels Al... Read More about Generating Skeletal Diversity and Complexity from Boron-Substituted 1,3-Dienes and Enophiles.

Access to Fused Pyrroles from Cyclic 1,3-Dienyl Boronic Esters and Arylnitroso Compounds (2020)
Journal Article
François, B., Eberlin, L., Berrée, F., Whiting, A., & Carboni, B. (2020). Access to Fused Pyrroles from Cyclic 1,3-Dienyl Boronic Esters and Arylnitroso Compounds. Journal of Organic Chemistry, 85(8), 5173-5182. https://doi.org/10.1021/acs.joc.9b03214

Complimentary to classical hydroboration and boron-Wittig reactions, a new, efficient access to cyclic 1,3-dienyl boronic esters has been developed via diene or triene metathesis. Subsequently, fused pyrroles were synthesized with a broad substrate s... Read More about Access to Fused Pyrroles from Cyclic 1,3-Dienyl Boronic Esters and Arylnitroso Compounds.

Decay in Retinoic Acid Signaling in Varied Models of Alzheimer’s Disease and In-Vitro Test of Novel Retinoic Acid Receptor Ligands (RAR-Ms) to Regulate Protective Genes (2020)
Journal Article
Khatib, T., Chisholm, D. R., Whiting, A., Platt, B., & McCaffery, P. (2020). Decay in Retinoic Acid Signaling in Varied Models of Alzheimer’s Disease and In-Vitro Test of Novel Retinoic Acid Receptor Ligands (RAR-Ms) to Regulate Protective Genes. Journal of Alzheimer's Disease, 73(3), 935-954. https://doi.org/10.3233/jad-190931

Retinoic acid has been previously proposed in the treatment of Alzheimer’s disease (AD). Here, five transgenic mouse models expressing AD and frontotemporal dementia risk genes (i.e., PLB2APP, PLB2TAU, PLB1Double, PLB1Triple, and PLB4) were used to i... Read More about Decay in Retinoic Acid Signaling in Varied Models of Alzheimer’s Disease and In-Vitro Test of Novel Retinoic Acid Receptor Ligands (RAR-Ms) to Regulate Protective Genes.

Adding Value to Waste Minerals in a Circular Economy Framework: Ochre-Derived Layered Double Hydroxide Catalysts in Fatty Acid Ketonisation (2019)
Journal Article
Perera-Solis, D. D., Pimlott, M., Fidment, E., Whiting, A., & Greenwell, H. C. (2019). Adding Value to Waste Minerals in a Circular Economy Framework: Ochre-Derived Layered Double Hydroxide Catalysts in Fatty Acid Ketonisation. Minerals, 9(11), Article 681. https://doi.org/10.3390/min9110681

Mineral carbonation is known to be among the most efficient ways to reduce the anthropogenic emissions of carbon dioxide. Serpentine minerals (Mg3Si2O5(OH)4), have shown great potential for carbonation. A way to improve yield is to thermally activate... Read More about Adding Value to Waste Minerals in a Circular Economy Framework: Ochre-Derived Layered Double Hydroxide Catalysts in Fatty Acid Ketonisation.