Professor Ann O'Donoghue's Outputs (2)

Triazolium Salt Organocatalysis: Mechanistic Evaluation of Unusual Ortho-Substituent Effects on Deprotonation (2021)
Journal Article
Quinn, P., Smith, M. S., Zhu, J., Hodgson, D. R., & O’Donoghue, A. C. (2021). Triazolium Salt Organocatalysis: Mechanistic Evaluation of Unusual Ortho-Substituent Effects on Deprotonation. Catalysts, 11(9), Article 1055. https://doi.org/10.3390/catal11091055

Organocatalysis by N-heterocyclic carbenes is normally initiated by the deprotonation of precursor azolium ions to form active nucleophilic species. Substituent effects on deprotonation have an impact on catalytic efficiency and provide insight into... Read More about Triazolium Salt Organocatalysis: Mechanistic Evaluation of Unusual Ortho-Substituent Effects on Deprotonation.

Kinetic and Structure–Activity Studies of the Triazolium Ion– catalyzed Intramolecular Stetter Reaction (2021)
Journal Article
Collett, C. J., Young, C. M., Massey, R. S., O'Donoghue, A. C., & Smith, A. D. (2021). Kinetic and Structure–Activity Studies of the Triazolium Ion– catalyzed Intramolecular Stetter Reaction. European Journal of Organic Chemistry, 2021(26), 3670-3675. https://doi.org/10.1002/ejoc.202100384

Mechanistic studies of the triazolium ion-catalyzed intramolecular Stetter reaction using initial rates analysis in NEt3/NEt3HCl buffered methanol showed the reaction to be first-order in catalyst and zero-order in aldehyde over a broad range of ald... Read More about Kinetic and Structure–Activity Studies of the Triazolium Ion– catalyzed Intramolecular Stetter Reaction.