Professor Ann O'Donoghue's Outputs (3)

Proton transfer reactions of N-aryl triazolium salts: unusual ortho-substituent effects (2014)
Journal Article
Tucker, D., Quinn, P., Massey, R., Collett, C., Jasiewicz, D., Bramley, C., …O'Donoghue, A. (2015). Proton transfer reactions of N-aryl triazolium salts: unusual ortho-substituent effects. Journal of Physical Organic Chemistry, 28(2), 108-115. https://doi.org/10.1002/poc.3399

Previous studies of the C(3)-hydrogen/deuterium exchange reactions of the triazolium ion conjugate acids of triazolyl N-heterocyclic carbenes revealed a change of mechanism under acidic conditions with N1-protonation to a dicationic salt. Interesting... Read More about Proton transfer reactions of N-aryl triazolium salts: unusual ortho-substituent effects.

Editorial overview: Mechanisms: Chemical and computational probes of biological mechanism (2014)
Journal Article
O'Donoghue, A., & Kamerlin, S. (2014). Editorial overview: Mechanisms: Chemical and computational probes of biological mechanism. Current Opinion in Chemical Biology, 21, viii-x. https://doi.org/10.1016/j.cbpa.2014.07.025

Enzyme Architecture: The Effect of Replacement and Deletion Mutations of Loop 6 on Catalysis by Triosephosphate Isomerase (2014)
Journal Article
Zhai, X., Go, M., O'Donoghue, A., Amyes, T., Pegan, S., Wang, Y., …Richard, J. (2014). Enzyme Architecture: The Effect of Replacement and Deletion Mutations of Loop 6 on Catalysis by Triosephosphate Isomerase. Biochemistry, 53(21), 3486-3501. https://doi.org/10.1021/bi500458t

Two mutations of the phosphodianion gripper loop in chicken muscle triosephosphate isomerase (cTIM) were examined: (1) the loop deletion mutant (LDM) formed by removal of residues 170–173 [Pompliano, D. L., et al. (1990) Biochemistry 29, 3186–3194] a... Read More about Enzyme Architecture: The Effect of Replacement and Deletion Mutations of Loop 6 on Catalysis by Triosephosphate Isomerase.