Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule.
(2024)
Journal Article
Kelly, G., Kataura, T., Panek, J., Ma, G., Salmonowicz, H., Davis, A., Kendall, H., Brookes, C., Ayine-Tora, D. M., Banks, P., Nelson, G., Dobby, L., Pitrez, P. R., Booth, L., Costello, L., Richardson, G. D., Lovat, P., Przyborski, S., Ferreira, L., Greaves, L., …Korolchuk, V. I. (2024). Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule. Developmental Cell, 59(15), 1924-1939. https://doi.org/10.1016/j.devcel.2024.04.020
Selective degradation of damaged mitochondria by autophagy (mitophagy) is proposed to play an important role in cellular homeostasis. However, the molecular mechanisms and the requirement of mitochondrial quality control by mitophagy for cellular phy... Read More about Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule..