Dr Gary Sharples' Outputs (3)

A critical role for iron and zinc homeostatic systems in the evolutionary adaptation of Escherichia coli to metal restriction (2023)
Journal Article
Paterson, J. R., Wadsworth, J. M., Hu, P., & Sharples, G. J. (2023). A critical role for iron and zinc homeostatic systems in the evolutionary adaptation of Escherichia coli to metal restriction. Microbial Genomics, 9(12), Article 001153. https://doi.org/10.1099/mgen.0.001153

Host nutritional immunity utilizes metal deprivation to help prevent microbial infection. To investigate bacterial adaptation to such restrictive conditions, we conducted experimental evolution with two metal sequestering agents. Ethylenediaminetetra... Read More about A critical role for iron and zinc homeostatic systems in the evolutionary adaptation of Escherichia coli to metal restriction.

The antibacterial activity of a photoactivatable diarylacetylene against Gram-positive bacteria (2023)
Journal Article
Waite, R., Adams, C. T., Chisholm, D. R., Sims, C. H. C., Hughes, J. G., Dias, E., …Ambler, C. A. (2023). The antibacterial activity of a photoactivatable diarylacetylene against Gram-positive bacteria. Frontiers in Microbiology, 14, Article 1243818. https://doi.org/10.3389/fmicb.2023.1243818

The emergence of antibiotic resistance is a growing threat to human health, and therefore, alternatives to existing compounds are urgently needed. In this context, a novel fluorescent photoactivatable diarylacetylene has been identified and character... Read More about The antibacterial activity of a photoactivatable diarylacetylene against Gram-positive bacteria.

Effect of natural antibacterial clays against single biofilm formation by Staphylococcus aureus and Salmonella Typhimurium bacteria on a stainless-steel surface (2023)
Journal Article
Wan Omar, W. H., Mahyudin, N. A., Azmi, N. N., Mahmud Ab Rashid, N., Ismail, R., Mohd Yusoff, M. H. Y., …Sharples, G. J. (2023). Effect of natural antibacterial clays against single biofilm formation by Staphylococcus aureus and Salmonella Typhimurium bacteria on a stainless-steel surface. International Journal of Food Microbiology, 394, Article 110184. https://doi.org/10.1016/j.ijfoodmicro.2023.110184

Staphylococcus aureus and Salmonella Typhimurium have a propensity to develop biofilms on food contact surfaces, such as stainless-steel, that persist despite rigorous cleaning and sanitizing procedures. Since both bacterial species pose a significan... Read More about Effect of natural antibacterial clays against single biofilm formation by Staphylococcus aureus and Salmonella Typhimurium bacteria on a stainless-steel surface.