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Dr Gary Sharples' Outputs (3)

Novel antibiotics: second generation macrocyclic peptides designed to trap Holliday junctions. (2004)
Journal Article
Liotta, L., Medina, I., Robinson, J., Carroll, C., Pan, P., Corral, R., …McAlpine, S. (2004). Novel antibiotics: second generation macrocyclic peptides designed to trap Holliday junctions. Tetrahedron Letters, 45, 8447-8450. https://doi.org/10.1016/j.tetlet.2004.09.084

Described are the syntheses of 15 macrocyclic peptides designed to trap Holliday junctions(HJs) in bacteria during site-specific and homologous recombination. This leads to inhibiting bacterial growth. These second generation macrocycles were based o... Read More about Novel antibiotics: second generation macrocyclic peptides designed to trap Holliday junctions..

Holliday Junction Binding and Resolution by the Rap Structure-specific Endonuclease of Phage lambda (2004)
Journal Article
Sharples, G., Curtis, F., McGlynn, P., & Bolt, E. (2004). Holliday Junction Binding and Resolution by the Rap Structure-specific Endonuclease of Phage lambda. Journal of Molecular Biology, 340(4), 739-751. https://doi.org/10.1016/j.jmb.2004.05.030

Rap endonuclease targets recombinant joint molecules arising from phage lambda Red-mediated genetic exchange. Previous studies revealed that Rap nicks DNA at the branch point of synthetic Holliday junctions and other DNA structures with a branched co... Read More about Holliday Junction Binding and Resolution by the Rap Structure-specific Endonuclease of Phage lambda.