Professor Colin Jahoda's Outputs (31)

Dominant effect of gap junction communication in wound‐induced calcium‐wave, NFAT activation and wound closure in keratinocytes (2021)
Journal Article
Hudson, L., Begg, M., Wright, B., Cheek, T., Jahoda, C. A., & Reynolds, N. J. (2021). Dominant effect of gap junction communication in wound‐induced calcium‐wave, NFAT activation and wound closure in keratinocytes. Journal of Cellular Physiology, 236(12), 8171-8183. https://doi.org/10.1002/jcp.30488

Wounding induces a calcium wave and disrupts the calcium gradient across the epidermis but mechanisms mediating calcium and downstream signalling, and longer-term wound healing responses are incompletely understood. As expected, live-cell confocal im... Read More about Dominant effect of gap junction communication in wound‐induced calcium‐wave, NFAT activation and wound closure in keratinocytes.

Tissue engineering of human hair follicles using a biomimetic developmental approach (2018)
Journal Article
Abaci, H. E., Coffman, A., Doucet, Y., Chen, J., Jacków, J., Wang, E., Guo, Z., Shin, J. U., Jahoda, C. A., & Christiano, A. M. (2018). Tissue engineering of human hair follicles using a biomimetic developmental approach. Nature Communications, 9(1), Article 5301. https://doi.org/10.1038/s41467-018-07579-y

Human skin constructs (HSCs) have the potential to provide an effective therapy for patients with significant skin injuries and to enable human-relevant drug screening for skin diseases; however, the incorporation of engineered skin appendages, such... Read More about Tissue engineering of human hair follicles using a biomimetic developmental approach.

Hair Follicle Dermal Cells Support Expansion of Murine and Human Embryonic and Induced Pluripotent Stem Cells and Promote Haematopoiesis in Mouse Cultures (2018)
Journal Article
Liu, J., Higgins, C. A., Whitehouse, J. C., Harris, S. J., Crawford, H., Christiano, A. M., Lako, M., Hole, N., & Jahoda, C. A. (2018). Hair Follicle Dermal Cells Support Expansion of Murine and Human Embryonic and Induced Pluripotent Stem Cells and Promote Haematopoiesis in Mouse Cultures. Stem Cells International, 2018, Article 8631432. https://doi.org/10.1155/2018/8631432

In the hair follicle, the dermal papilla (DP) and dermal sheath (DS) support and maintain proliferation and differentiation of the epithelial stem cells that produce the hair fibre. In view of their regulatory properties, in this study, we investigat... Read More about Hair Follicle Dermal Cells Support Expansion of Murine and Human Embryonic and Induced Pluripotent Stem Cells and Promote Haematopoiesis in Mouse Cultures.

Hierarchical patterning modes orchestrate hair follicle morphogenesis (2017)
Journal Article
Glover, J. D., Wells, K. L., Matthäus, F., Painter, K. J., Ho, W., Riddell, J., …Headon, D. J. (2017). Hierarchical patterning modes orchestrate hair follicle morphogenesis. PLoS Biology, 15(7), Article e2002117. https://doi.org/10.1371/journal.pbio.2002117

Two theories address the origin of repeating patterns, such as hair follicles, limb digits, and intestinal villi, during development. The Turing reaction–diffusion system posits that interacting diffusible signals produced by static cells first defin... Read More about Hierarchical patterning modes orchestrate hair follicle morphogenesis.

Multifaceted role of hair follicle dermal cells in bioengineered skins (2017)
Journal Article
Higgins, C., Roger, M., Hill, R., Ali-Khan, A., Garlick, J., Christiano, A., & Jahoda, C. (2017). Multifaceted role of hair follicle dermal cells in bioengineered skins. British Journal of Dermatology, 176(5), 1259-1269. https://doi.org/10.1111/bjd.15087

Background The method of generating bioengineered skin constructs was pioneered several decades ago; nowadays these constructs are used regularly for the treatment of severe burns and nonhealing wounds. Commonly, these constructs are comprised of ski... Read More about Multifaceted role of hair follicle dermal cells in bioengineered skins.

What Lies Beneath: Wnt/β-Catenin Signaling and Cell Fate in the Lower Dermis (2016)
Journal Article
Jahoda, C., & Gilmore, A. (2016). What Lies Beneath: Wnt/β-Catenin Signaling and Cell Fate in the Lower Dermis. Journal of Investigative Dermatology, 136(6), 1084-1087. https://doi.org/10.1016/j.jid.2016.03.029

Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium (2015)
Journal Article
Mardaryev, A., Liu, B., Rapisarda, V., Poterlowicz, K., Malashchuk, I., Rudolf, J., …Botchkarev, V. (2016). Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium. Journal of Cell Biology, 212(1), 77-89. https://doi.org/10.1083/jcb.201506065

During development, multipotent progenitor cells establish lineage-specific programmers of gene activation and silencing underlying their differentiation into specialized cell types. We show that the Polycomb component Cbx4 serves as a critical deter... Read More about Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium.

Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth. (2013)
Journal Article
Higgins, C., Chen, J., Cerise, J., Jahoda, C., & Christiano, A. (2013). Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth. Proceedings of the National Academy of Sciences, 110(49), https://doi.org/10.1073/pnas.1309970110

Development of the mouse dermal adipose layer occurs independently of subcutaneous adipose tissue and is marked by restricted early expression of FABP4 (2013)
Journal Article
Wojciechowicz, K., Gledhill, K., Ambler, C., Manning, C., & Jahoda, C. (2013). Development of the mouse dermal adipose layer occurs independently of subcutaneous adipose tissue and is marked by restricted early expression of FABP4. PLoS ONE, 8(3), Article e59811. https://doi.org/10.1371/journal.pone.0059811

The laboratory mouse is a key animal model for studies of adipose biology, metabolism and disease, yet the developmental changes that occur in tissues and cells that become the adipose layer in mouse skin have received little attention. Moreover, the... Read More about Development of the mouse dermal adipose layer occurs independently of subcutaneous adipose tissue and is marked by restricted early expression of FABP4.

Modulation in proteolytic activity is identified as a hallmark of exogen by transcriptional profiling of hair follicles (2011)
Journal Article
Higgins, C., Westgate, G., & Jahoda, C. (2011). Modulation in proteolytic activity is identified as a hallmark of exogen by transcriptional profiling of hair follicles. Journal of Investigative Dermatology, 131, 2349-2357. https://doi.org/10.1038/jid.2011.227

Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. (2010)
Journal Article
Petukhova, L., Duvic, M., Hordinsky, M., Norris, D., Price, V., Shimomura, Y., …Christiano, A. (2010). Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. Nature, 466(7302), 113-117. https://doi.org/10.1038/nature09114

From telogen to exogen: mechanisms underlying formation and subsequent loss of the hair club fiber (2009)
Journal Article
Higgins, C. A., Westgate, G. E., & Jahoda, C. A. (2009). From telogen to exogen: mechanisms underlying formation and subsequent loss of the hair club fiber. Journal of Investigative Dermatology, 129, 2100-2108. https://doi.org/10.1038/jid.2009.66

KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin (2009)
Journal Article
Richardson, G., Bazzi, H., Fantauzzo, K., Waters, J., Crawford, H., Hynd, P., …Jahoda, C. (2009). KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin. Development, 136(13), 2153-2164. https://doi.org/10.1242/dev.031427

C/EBPalpha identifies differentiating preadipocytes around hair follicles in foetal and neonatal rat and mouse skin (2008)
Journal Article
Wojciechowicz, K., Markiewicz, E., & Jahoda, C. (2008). C/EBPalpha identifies differentiating preadipocytes around hair follicles in foetal and neonatal rat and mouse skin. Experimental Dermatology, 17(8), 675-680. https://doi.org/10.1111/j.1600-0625.2007.00689.x

Transformation of amnion epithelium into skin. (2004)
Journal Article
Fliniaux, I., Viallet, J., Dhouailly, D., & Jahoda, C. (2004). Transformation of amnion epithelium into skin. Differentiation, 72, 558-565. https://doi.org/10.1111/j.1432-0436.2004.07209009.x

Cultured human and rat tooth papilla cells induce hair follicle regeneration and fiber growth (2004)
Journal Article
Reynolds, A., & Jahoda, C. (2004). Cultured human and rat tooth papilla cells induce hair follicle regeneration and fiber growth. Differentiation, 72(9-10), 566-575. https://doi.org/10.1111/j.1432-0436.2004.07209010.x

The mesenchymal–epithelial interactions that characterize the early stages of tooth and hair follicle morphogenesis share certain similarities, and there is increasing evidence that mesenchymal cells derived from both mature structures retain interac... Read More about Cultured human and rat tooth papilla cells induce hair follicle regeneration and fiber growth.

The lanceolate hair rat phenotype results from a missense mutation in a calcium coordinating site of the desmoglein 4 gene (2004)
Journal Article
Jahoda, C., Kljuic, A., O'Shaughnessy, R., Crossley, N., Whitehouse, C., Robinson, M., …Christiano, A. (2004). The lanceolate hair rat phenotype results from a missense mutation in a calcium coordinating site of the desmoglein 4 gene. Genomics, 83(5), 747-756

Hair follicle dermal cells differentiate into adipogenic and osteogenic lineages (2003)
Journal Article
Jahoda, C., Whitehouse, C., Reynolds, A., & Hole, N. (2003). Hair follicle dermal cells differentiate into adipogenic and osteogenic lineages. Experimental Dermatology, 12(6), 849-859. https://doi.org/10.1111/j.0906-6705.2003.00161.x

The adult hair follicle dermal papilla (DP) and dermal sheath (DS) cells are developmentally active cell populations with a proven role in adult hair follicle-cycling activity and unique inductive powers. In stem cell biology, the hair follicle epith... Read More about Hair follicle dermal cells differentiate into adipogenic and osteogenic lineages.

Plasticity of hair follicle dermal cells in wound healing and induction (2003)
Journal Article
Gharzi, A., Reynolds, A., & Jahoda, C. (2003). Plasticity of hair follicle dermal cells in wound healing and induction. Experimental Dermatology, 12(2), 126-136. https://doi.org/10.1034/j.1600-0625.2003.00106.x

Desmoglein 4 in hair follicle differentiation and epidermal adhesion: Evidence from inherited hypotrichosis and acquired pemphigus vulgaris (2003)
Journal Article
Kljuic, A., Bazzi, H., Sundberg, J., Martinez-Mir, A., O'Shaughnessy, R., Mahoney, M., …Christiano, A. (2003). Desmoglein 4 in hair follicle differentiation and epidermal adhesion: Evidence from inherited hypotrichosis and acquired pemphigus vulgaris. Cell, 113(2), 249-260. https://doi.org/10.1016/s0092-8674%2803%2900273-3

Cell adhesion and communication are interdependent aspects of cell behavior that are critical for morphogenesis and tissue architecture. In the skin, epidermal adhesion is mediated in part by specialized cell-cell junctions known as desmosomes, which... Read More about Desmoglein 4 in hair follicle differentiation and epidermal adhesion: Evidence from inherited hypotrichosis and acquired pemphigus vulgaris.