Manipulation of oxidative protein folding and PDI redox state in mammalian cells.
(2001)
Journal Article
Mezghrani, A., Fassio, A., Benham, A., Simmen, T., Braakman, I., & Sitia, R. (2001). Manipulation of oxidative protein folding and PDI redox state in mammalian cells. The EMBO Journal, 20(22), 6288-6296. https://doi.org/10.1093/emboj/20.22.6288
In the endoplasmic reticulum (ER), disulfide bonds are simultaneously formed in nascent proteins and removed from incorrectly folded or assembled molecules. In this compartment, the redox state must be, therefore, precisely regulated. Here we show th... Read More about Manipulation of oxidative protein folding and PDI redox state in mammalian cells..