All Outputs (4)

Mutant p53 induces SH3BGRL expression to promote cell engulfment (2025)
Journal Article
Muller, P., Dolma, L., Banyard, A., Hall, C., Breitweiser, W., Sahoo, S., Weightman, J., Pazos Gil, M., Behan, C., Fullard, N., Williams, L., Ashton, G., Bell, S., & Patterson, M. (2025). Mutant p53 induces SH3BGRL expression to promote cell engulfment. Cell Death Discovery, 11, Article 288. https://doi.org/10.1038/s41420-025-02582-x

Previously, we identified that mutant p53 expression in cancer cells promotes engulfment of neighbouring cancer cells to form cell-in-cell (CIC) structures. This process gave mutant p53 cells an advantage in tumour formation in mouse xenograft experi... Read More about Mutant p53 induces SH3BGRL expression to promote cell engulfment.

New imaging tools reveal live cellular collagen secretion, fibril dynamics and network organisation (2025)
Journal Article
Kent, O., Casey, E. R., Brown, M., Bell, S., Ehrman, M. C., Flagler, M. J., Määttä, A., Benham, A. M., & Hawkins, T. J. (2025). New imaging tools reveal live cellular collagen secretion, fibril dynamics and network organisation. Scientific Reports, 15, Article 13764. https://doi.org/10.1038/s41598-025-96280-4

Although light microscopy has been used to examine the early trafficking of collagen within the cell, much of our understanding of the detailed organisation of cell deposited collagen is from static electron microscopy studies. To understand the dyna... Read More about New imaging tools reveal live cellular collagen secretion, fibril dynamics and network organisation.

Elucidation of the AGR2 interactome in esophageal adenocarcinoma cells identifies a redox sensitive chaperone hub for the quality control of MUC-5AC (2019)
Journal Article
Worfolk, J., Bell, S., Simpson, L., Carne, N., Francis, S., Engelbertsen, V., Brown, A., Walker, J., Viswanath, Y., & Benham, A. (2019). Elucidation of the AGR2 interactome in esophageal adenocarcinoma cells identifies a redox sensitive chaperone hub for the quality control of MUC-5AC. Antioxidants and Redox Signaling, 31(15), 1117-1132. https://doi.org/10.1089/ars.2018.7647

Aims: AGR2 is a tissue-restricted member of the protein disulfide isomerase family that has attracted interest because it is highly expressed in a number of cancers, including gastroesophageal adenocarcinoma. The behavior of AGR2 was analyzed under o... Read More about Elucidation of the AGR2 interactome in esophageal adenocarcinoma cells identifies a redox sensitive chaperone hub for the quality control of MUC-5AC.

Reductive stress selectively disrupts collagen homeostasis and modifies growth factor-independent signalling through the MAPK/Akt pathway in human dermal fibroblasts (2019)
Journal Article
Carne, N., Brown, A., Bell, S., Maatta, A., Flagler, M., & Benham, A. (2019). Reductive stress selectively disrupts collagen homeostasis and modifies growth factor-independent signalling through the MAPK/Akt pathway in human dermal fibroblasts. Molecular and Cellular Proteomics, 18(6), 1123-1137. https://doi.org/10.1074/mcp.ra118.001140

Redox stress is a well-known contributor to ageing and diseases in skin. Reductants such as dithiothreitol (DTT) can trigger a stress response by disrupting disulfide bonds. However, the quantitative response of the cellular proteome to reductants ha... Read More about Reductive stress selectively disrupts collagen homeostasis and modifies growth factor-independent signalling through the MAPK/Akt pathway in human dermal fibroblasts.