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Insights into genetic diversity, parentage and group composition of Atlantic white-sided dolphins (Lagenorhynchus acutus) in the west of Ireland based on nuclear and mitochondrial genetic markers. (2011)
Journal Article
Mirimin, L., Banguera-Hinestroza, E., Hoelzel, A., R, C., !&, T., & gan, E. (2011). Insights into genetic diversity, parentage and group composition of Atlantic white-sided dolphins (Lagenorhynchus acutus) in the west of Ireland based on nuclear and mitochondrial genetic markers. Journal of Heredity, 102(1), 79-87. https://doi.org/10.1093/jhered/esq106

Alexander disease causing mutations in the C-terminal domain of GFAP are deleterious both to assembly and network formation with the potential to both activate caspase 3 and decrease cell viability (2011)
Journal Article
Chen, Y., Lim, S., Chen, M., Quinlan, R. A., & Perng, M. (2011). Alexander disease causing mutations in the C-terminal domain of GFAP are deleterious both to assembly and network formation with the potential to both activate caspase 3 and decrease cell viability. Experimental Cell Research, 317(16), 2252-2266. https://doi.org/10.1016/j.yexcr.2011.06.017

Phenotypic Characterization of a copA Mutant of Neisseria gonorrhoeae Identifies a Link between Copper and Nitrosative Stress (2011)
Journal Article
Djoko, K., Franiek, J., Edwards, J., Falsetta, M., Kidd, S., Potter, A., …McEwan, A. (2012). Phenotypic Characterization of a copA Mutant of Neisseria gonorrhoeae Identifies a Link between Copper and Nitrosative Stress. Infection and Immunity, 80(3), 1065-1071. https://doi.org/10.1128/iai.06163-11

NGO0579 is annotated copA in the Neisseria gonorrhoeae chromosome, suggesting that it encodes a cation-transporting ATPase specific for copper ions. Compared to wild-type cells, a copA mutant was more sensitive to killing by copper ions but not to ot... Read More about Phenotypic Characterization of a copA Mutant of Neisseria gonorrhoeae Identifies a Link between Copper and Nitrosative Stress.

Larval source management for malaria control in Africa: myths and reality (2011)
Journal Article
Fillinger, U., & Lindsay, S. (2011). Larval source management for malaria control in Africa: myths and reality. Malaria Journal, 10, Article 353. https://doi.org/10.1186/1475-2875-10-353

As malaria declines in many African countries there is a growing realization that new interventions need to be added to the front-line vector control tools of long-lasting impregnated nets (LLINs) and indoor residual spraying (IRS) that target adult... Read More about Larval source management for malaria control in Africa: myths and reality.

Evolution of the vertebrate beaded filament protein, Bfsp2; comparing the in vitro assembly properties of a “tailed” zebrafish Bfsp2 to its “tailless” human orthologue. (2011)
Journal Article
Qu, B., Landsbury, A., Schoenthaler, H. B., Dahm, R., Liu, Y., Clark, J. I., …Quinlan, R. A. (2012). Evolution of the vertebrate beaded filament protein, Bfsp2; comparing the in vitro assembly properties of a “tailed” zebrafish Bfsp2 to its “tailless” human orthologue. Experimental Eye Research, 94(1), 192-202. https://doi.org/10.1016/j.exer.2011.12.001

In bony fishes, Bfsp2 orthologues are predicted to possess a C-terminal tail domain, which is absent from avian, amphibian and mammalian Bfsp2 sequences. These sequences, are however, not conserved between fish species and therefore questions whether... Read More about Evolution of the vertebrate beaded filament protein, Bfsp2; comparing the in vitro assembly properties of a “tailed” zebrafish Bfsp2 to its “tailless” human orthologue..

Identification of novel androgen-regulated pathways and mRNA isoforms through genome-wide exon-specific profiling of the LNCaP transcriptome (2011)
Journal Article
Rajan, P., Dalgliesh, C., Carling, P., Buist, T., Zhang, C., Grellscheid, S., …Elliott, D. (2011). Identification of novel androgen-regulated pathways and mRNA isoforms through genome-wide exon-specific profiling of the LNCaP transcriptome. PLoS ONE, 6(12), Article e29088. https://doi.org/10.1371/journal.pone.0029088

Androgens drive the onset and progression of prostate cancer (PCa) by modulating androgen receptor (AR) transcriptional activity. Although several microarray-based studies have identified androgen-regulated genes, here we identify in-parallel global... Read More about Identification of novel androgen-regulated pathways and mRNA isoforms through genome-wide exon-specific profiling of the LNCaP transcriptome.

Identification of evolutionarily conserved exons as regulated targets for the splicing activator tra2β in development (2011)
Journal Article
Grellscheid, S., Dalgliesh, C., Storbeck, M., Best, A., Liu, Y., Jakubik, M., Mende, Y., Ehrmann, I., Curk, T., Rossbach, K., Bourgeois, C. F., Stévenin, J., Grellscheid, D., Jackson, M. S., Wirth, B., & Elliott, D. J. (2011). Identification of evolutionarily conserved exons as regulated targets for the splicing activator tra2β in development. PLoS Genetics, 7(12), Article e1002390. https://doi.org/10.1371/journal.pgen.1002390

Alternative splicing amplifies the information content of the genome, creating multiple mRNA isoforms from single genes. The evolutionarily conserved splicing activator Tra2β (Sfrs10) is essential for mouse embryogenesis and implicated in spermatogen... Read More about Identification of evolutionarily conserved exons as regulated targets for the splicing activator tra2β in development.

Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation (2011)
Journal Article
Pekovic, V., Gibbs-Seymour, I., Markiewicz, E., Alzoghaibi, F., Benham, A., Edwards, R., …Hutchison, C. (2011). Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation. Aging Cell, 10(6), 1067-1079. https://doi.org/10.1111/j.1474-9726.2011.00750.x

Pre-lamin A and progerin have been implicated in normal aging, and the pathogenesis of age-related degenerative diseases is termed ‘laminopathies’. Here, we show that mature lamin A has an essential role in cellular fitness and that oxidative damage... Read More about Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation.

The comparative importance of species traits and introduction characteristics in tropical plant invasions. (2011)
Journal Article
Dawson, W., Burslem, D., & Hulme, P. (2011). The comparative importance of species traits and introduction characteristics in tropical plant invasions. Diversity and Distributions, 17(6), 1111-1121. https://doi.org/10.1111/j.1472-4642.2011.00796.x

Aim  We used alien plant species introduced to a botanic garden to investigate the relative importance of species traits (leaf traits, dispersal syndrome) and introduction characteristics (propagule pressure, residence time and distance to forest) in... Read More about The comparative importance of species traits and introduction characteristics in tropical plant invasions..

Multiple Sites in alpha B-Crystallin Modulate Its Interactions with Desmin Filaments Assembled In Vitro (2011)
Journal Article
Houck, S. A., Landsbury, A., Clark, J. I., & Quinlan, R. A. (2011). Multiple Sites in alpha B-Crystallin Modulate Its Interactions with Desmin Filaments Assembled In Vitro. PLoS ONE, 6(11), Article e25859. https://doi.org/10.1371/journal.pone.0025859

The β3- and β8-strands and C-terminal residues 155–165 of αB-crystallin were identified by pin arrays as interaction sites for various client proteins including the intermediate filament protein desmin. Here we present data using 5 well-characterised... Read More about Multiple Sites in alpha B-Crystallin Modulate Its Interactions with Desmin Filaments Assembled In Vitro.