All Outputs (3481)

Engaging Students Through Self-Assessment in Practical Classes (2023)
Journal Article
Milian, J. (2023). Engaging Students Through Self-Assessment in Practical Classes. Journal of International Scientific Publications: Educational Alternatives, 21, 73-84

The project focus was on the implementation of self-assessment in undergraduate chemistry labs to improve student comprehension of practical laboratory skills. During 2nd year undergraduate practical organic lab sessions, students were asked to engag... Read More about Engaging Students Through Self-Assessment in Practical Classes.

Combined imaging and chromatic confocal microscopy technique to characterize size and shape of ensembles of cuboidal particles (2023)
Journal Article
Neoptolemou, P., Vetter, T., Cruz-Cabeza, A. J., & Rajagopalan, A. K. (in press). Combined imaging and chromatic confocal microscopy technique to characterize size and shape of ensembles of cuboidal particles. Powder Technology, 430, Article 119032. https://doi.org/10.1016/j.powtec.2023.119032

The presence of needle- and plate-like particles has detrimental consequences on their downstream processing in the fine chemicals sector. Therefore, the ability to accurately characterize the particle size and shape is essential t... Read More about Combined imaging and chromatic confocal microscopy technique to characterize size and shape of ensembles of cuboidal particles.

The Effect of Pulling and Twisting Forces on Chameleon Sequence Peptides. (2023)
Journal Article
Meadows, J., & Röder, K. (2023). The Effect of Pulling and Twisting Forces on Chameleon Sequence Peptides. ChemPhysChem, 24(24), Article e202300351. https://doi.org/10.1002/cphc.202300351

Chameleon sequences are amino acid sequences found in several distinct configurations in experiment. They challenge our understanding of the link between sequence and structure, and provide insight into structural competition in proteins. Here, we st... Read More about The Effect of Pulling and Twisting Forces on Chameleon Sequence Peptides..

Note: Photoelectron imaging of MnO3- to probe its nuclear and electronic structure. (2023)
Journal Article
Gibbard, J. A., Reppel, J., & Verlet, J. R. R. (2023). Note: Photoelectron imaging of MnO3- to probe its nuclear and electronic structure. The Journal of Chemical Physics, 159(14), Article 146101. https://doi.org/10.1063/5.0171346

Assessing Dose-Exposure-Response Relationships of Miltefosine in Adults and Children using Physiologically-Based Pharmacokinetic Modeling Approach. (2023)
Journal Article
Madu, S. J., Wang, K., Chirumamilla, S. K., Turner, D. B., Steel, P. G., & Li, M. (2023). Assessing Dose-Exposure-Response Relationships of Miltefosine in Adults and Children using Physiologically-Based Pharmacokinetic Modeling Approach. Pharmaceutical Research, 10.1007/s11095-023-03610-0. https://doi.org/10.1007/s11095-023-03610-0

Miltefosine is the first and only oral medication to be successfully utilized as an antileishmanial agent. However, the drug is associated with differences in exposure patterns and cure rates among different population groups e.g. ethnicity and age (... Read More about Assessing Dose-Exposure-Response Relationships of Miltefosine in Adults and Children using Physiologically-Based Pharmacokinetic Modeling Approach..

Do metastable polymorphs always grow faster? Measuring and comparing growth kinetics of three polymorphs of tolfenamic acid (2023)
Journal Article
Sacchi, P., Neoptolemou, P., Davey, R. J., Reutzel-Edens, S. M., & Cruz-Cabeza, A. J. (2023). Do metastable polymorphs always grow faster? Measuring and comparing growth kinetics of three polymorphs of tolfenamic acid. Chemical Science, https://doi.org/10.1039/d3sc02040a

The phenomenon of molecular crystal polymorphism is of central importance for all those industries that rely on crystallisation for the manufacturing of their products. Computational methods for the evaluation of thermodynamic properties of polymorph... Read More about Do metastable polymorphs always grow faster? Measuring and comparing growth kinetics of three polymorphs of tolfenamic acid.

Toxoplasma ceramide synthases: Gene duplication, functional divergence, and roles in parasite fitness. (2023)
Journal Article
Koutsogiannis, Z., Mina, J. G., Albus, C. A., Kol, M. A., Holthuis, J. C. M., Pohl, E., & Denny, P. W. (2023). Toxoplasma ceramide synthases: Gene duplication, functional divergence, and roles in parasite fitness. FASEB Journal, 37(11), Article e23229. https://doi.org/10.1096/fj.202201603RRR

Toxoplasma gondii is an obligate, intracellular apicomplexan protozoan parasite of both humans and animals that can cause fetal damage and abortion and severe disease in the immunosuppressed. Sphingolipids have indispensable functions as signaling mo... Read More about Toxoplasma ceramide synthases: Gene duplication, functional divergence, and roles in parasite fitness..

Structural Diversity in Cyclometalated Diiridium(III) Complexes with Bridging syn and anti μ2‐Oxamidato and μ2‐Dithioxamidato Ligands (2023)
Journal Article
M'hamedi, A., Batsanov, A. S., Fox, M. A., Aguilar, J. A., & Bryce, M. R. (2023). Structural Diversity in Cyclometalated Diiridium(III) Complexes with Bridging syn and anti μ2‐Oxamidato and μ2‐Dithioxamidato Ligands. European Journal of Inorganic Chemistry, https://doi.org/10.1002/ejic.202300423

Six new diiridium complexes containing 2-methyl-6-phenylpyridyl as the cyclometalating ligand with a μ2-oxamidato or a μ2-dithioxamidato ligand as the bridge have been synthesized in 60–73 % yields. These complexes were revealed by multinuclear NMR s... Read More about Structural Diversity in Cyclometalated Diiridium(III) Complexes with Bridging syn and anti μ2‐Oxamidato and μ2‐Dithioxamidato Ligands.

Reduction-cleavable desferrioxamine B pulldown system enriches Ni( ii )-superoxide dismutase from a Streptomyces proteome (2023)
Journal Article
Ni, J., Wood, J. L., White, M. Y., Lihi, N., Markham, T. E., Wang, J., …Codd, R. (2023). Reduction-cleavable desferrioxamine B pulldown system enriches Ni( ii )-superoxide dismutase from a Streptomyces proteome. RSC Chemical Biology, https://doi.org/10.1039/d3cb00097d

Two resins with the hydroxamic acid siderophore desferrioxamine B (DFOB) immobilised as a free ligand or its Fe(iii) complex were prepared to screen the Streptomyces pilosus proteome for proteins involved in siderophore-mediated Fe(iii) uptake. The r... Read More about Reduction-cleavable desferrioxamine B pulldown system enriches Ni( ii )-superoxide dismutase from a Streptomyces proteome.

Multicolor Luminescence of a Polyurethane Derivative Driven by Heat/Light-Induced Aggregation (2023)
Journal Article
Jiang, N., Li, K., Xie, W., Zhang, S., Li, X., Hu, Y., …Bryce, M. R. (2023). Multicolor Luminescence of a Polyurethane Derivative Driven by Heat/Light-Induced Aggregation. Macromolecules, 56(19), 7721-7728. https://doi.org/10.1021/acs.macromol.3c01345

The study of aggregate formation and its controllable effect on luminescence behavior has a far-reaching influence in establishing a universal aggregation photophysical mechanism. In this paper, we obtained clusters with different extents of aggregat... Read More about Multicolor Luminescence of a Polyurethane Derivative Driven by Heat/Light-Induced Aggregation.

Pathway complexity in fibre assembly: from liquid crystals to hyper-helical gelmorphs. (2023)
Journal Article
Contreras-Montoya, R., Smith, J. P., Boothroyd, S. C., Aguilar, J. A., Mirzamani, M., Screen, M. A., …He, L. (2023). Pathway complexity in fibre assembly: from liquid crystals to hyper-helical gelmorphs. Chemical Science, 14(41), 11389-11401. https://doi.org/10.1039/d3sc03841f

Pathway complexity results in unique materials from the same components according to the assembly conditions. Here a chiral acyl-semicarbazide gelator forms three different gels of contrasting fibre morphology (termed 'gelmorphs') as well as lyotropi... Read More about Pathway complexity in fibre assembly: from liquid crystals to hyper-helical gelmorphs..

The antibacterial activity of a photoactivatable diarylacetylene against Gram-positive bacteria (2023)
Journal Article
Waite, R., Adams, C. T., Chisholm, D. R., Sims, C. H. C., Hughes, J. G., Dias, E., …Ambler, C. A. (2023). The antibacterial activity of a photoactivatable diarylacetylene against Gram-positive bacteria. Frontiers in Microbiology, 14, Article 1243818. https://doi.org/10.3389/fmicb.2023.1243818

The emergence of antibiotic resistance is a growing threat to human health, and therefore, alternatives to existing compounds are urgently needed. In this context, a novel fluorescent photoactivatable diarylacetylene has been identified and character... Read More about The antibacterial activity of a photoactivatable diarylacetylene against Gram-positive bacteria.

Disruption of the inositol phosphorylceramide synthase gene affects Trypanosoma cruzi differentiation and infection capacity (2023)
Journal Article
Dos Santos, N. S. A., Estevez-Castro, C. F., Macedo, J. P., Chame, D. F., Castro-Gomes, T., Santos-Cardoso, M., …Teixeira, S. M. R. (2023). Disruption of the inositol phosphorylceramide synthase gene affects Trypanosoma cruzi differentiation and infection capacity. PLoS Neglected Tropical Diseases, 17(9), Article e0011646. https://doi.org/10.1371/journal.pntd.0011646

Sphingolipids (SLs) are essential components of all eukaryotic cellular membranes. In fungi, plants and many protozoa, the primary SL is inositol-phosphorylceramide (IPC). Trypanosoma cruzi is a protozoan parasite that causes Chagas disease (CD), a c... Read More about Disruption of the inositol phosphorylceramide synthase gene affects Trypanosoma cruzi differentiation and infection capacity.

Near-Infrared Afterglow ONOO–-Triggered Nanoparticles for Real-Time Monitoring and Treatment of Early Ischemic Stroke (2023)
Journal Article
Zhang, L., Wang, Y., Liao, Y., Zhang, Q., Liu, X., Zhu, D., …Ren, L. (2023). Near-Infrared Afterglow ONOO–-Triggered Nanoparticles for Real-Time Monitoring and Treatment of Early Ischemic Stroke. ACS Applied Materials and Interfaces, https://doi.org/10.1021/acsami.3c08033

Early detection and drug intervention with the appropriate timing and dosage are the main clinical challenges for ischemic stroke (IS) treatment. The conventional therapeutic agents relay fluorescent signals, which require real-time external light ex... Read More about Near-Infrared Afterglow ONOO–-Triggered Nanoparticles for Real-Time Monitoring and Treatment of Early Ischemic Stroke.

Investigating groundwater recharge using hydrogen and oxygen stable isotopes in Kabul city, a semi-arid region (2023)
Journal Article
Hamidi, M. D., Gröcke, D. R., Kumar Joshi, S., & Greenwell, H. C. (2023). Investigating groundwater recharge using hydrogen and oxygen stable isotopes in Kabul city, a semi-arid region. Journal of Hydrology, 626, Article 130187. https://doi.org/10.1016/j.jhydrol.2023.130187

There are significant concerns about the sustainability of groundwater, and the inhabitants that depend on it, due to rapid groundwater depletion from the alluvium aquifers in Kabul city. Sustainable groundwater management in Kabul requires an unders... Read More about Investigating groundwater recharge using hydrogen and oxygen stable isotopes in Kabul city, a semi-arid region.

Cyclometallated Platinum(II) Complexes Featuring an Unusual, C^N‐Coordinating Pyridyl‐pyridylidene Ligand and L X Coligands: Synthesis, Structures and Dual Luminescence Behavior (2023)
Journal Article
Montagu, J., Gontard, G., Williams, J. A. G., & Moussa, J. (2023). Cyclometallated Platinum(II) Complexes Featuring an Unusual, C^N‐Coordinating Pyridyl‐pyridylidene Ligand and L X Coligands: Synthesis, Structures and Dual Luminescence Behavior. European Journal of Inorganic Chemistry, 26(32), Article e202300487. https://doi.org/10.1002/ejic.202300487

Thanks to an unusual protodemethylation reaction, a series of luminescent cyclometallated platinum(II) complexes can be prepared, which incorporate a rare NC-chelating, pyridyl-pyridylidene ligand, in combination with OO-coordinating acetylacetonate... Read More about Cyclometallated Platinum(II) Complexes Featuring an Unusual, C^N‐Coordinating Pyridyl‐pyridylidene Ligand and L X Coligands: Synthesis, Structures and Dual Luminescence Behavior.

Evaporation of alcohol droplets on surfaces in moist air (2023)
Journal Article
Yang, L., Pahlavan, A. A., Stone, H. A., & Bain, C. D. (2023). Evaporation of alcohol droplets on surfaces in moist air. Proceedings of the National Academy of Sciences, 120(38), Article e2302653120. https://doi.org/10.1073/pnas.2302653120

Droplets of alcohol-based formulations are common in applications from sanitising sprays to printing inks. However, our understanding of the drying dynamics of these droplets on surfaces and the influence of ambient humidity is still very limited. He... Read More about Evaporation of alcohol droplets on surfaces in moist air.

Retention and transport of PFOA and its fluorinated substitute, GenX, through water-saturated soil columns (2023)
Journal Article
Liu, G., Usman, M., Luo, T., Biard, P., Lin, K., Greenwell, H. C., & Hanna, K. (2023). Retention and transport of PFOA and its fluorinated substitute, GenX, through water-saturated soil columns. Environmental Pollution, 337, Article 122530. https://doi.org/10.1016/j.envpol.2023.122530

Perfluoro-2-propoxypropanoic acid (GenX) has emerged as a substitute for perfluorooctanoic acid (PFOA) especially since PFOA was listed among the persistent organic pollutants (POPs) by the Stockholm Convention in 2019. However, limited knowledge exi... Read More about Retention and transport of PFOA and its fluorinated substitute, GenX, through water-saturated soil columns.

Electron impact resonances of uracil in an aqueous environment from anion photoelectron imaging (2023)
Journal Article
Cooper, G. A., Clarke, C. J., & Verlet, J. R. R. (2023). Electron impact resonances of uracil in an aqueous environment from anion photoelectron imaging. Journal of Physics B: Atomic, Molecular and Optical Physics, 56(18), Article 185102. https://doi.org/10.1088/1361-6455/acf353

The effect that solvation has on electron attachment to uracil, U, was studied by probing the electronic resonances of the uracil radical anion, U−, in gas-phase water clusters, U−(H2O)n, using photoelectron imaging across a range of photon energies.... Read More about Electron impact resonances of uracil in an aqueous environment from anion photoelectron imaging.

Polymorphic Solid Solutions in Molecular Crystals: Tips, Tricks, and Switches (2023)
Journal Article
Hill, A., Kras, W., Theodosiou, F., Wanat, M., Lee, D., & Cruz-Cabeza, A. J. (2023). Polymorphic Solid Solutions in Molecular Crystals: Tips, Tricks, and Switches. Journal of the American Chemical Society, https://doi.org/10.1021/jacs.3c07105

Crystal polymorphism has been a topic of much interest for the past 20 years or so, especially since its scientific (and legal) importance to the pharmaceutical industry was realized. By contrast, the formation of solid solutions in molecular crystal... Read More about Polymorphic Solid Solutions in Molecular Crystals: Tips, Tricks, and Switches.