All Outputs (167)

Structure and Mechanism of Dimer-Monomer Transition of a Plant Poly(A)-Binding Protein upon RNA Interaction: Insights into Its Poly(A) Tail Assembly (2015)
Journal Article
Domingues, M., Sforça, M., Soprano, A., Lee, J., Campos Brasil de Souza, T. D. A., Cassago, A., …Benedetti, C. (2015). Structure and Mechanism of Dimer-Monomer Transition of a Plant Poly(A)-Binding Protein upon RNA Interaction: Insights into Its Poly(A) Tail Assembly. Journal of Molecular Biology, 427(15), 2491-2506. https://doi.org/10.1016/j.jmb.2015.05.017

Poly(A)-binding proteins (PABPs) play crucial roles in mRNA biogenesis, stability, transport and translational control in most eukaryotic cells. Although animal PABPs are well-studied proteins, the biological role, three-dimensional structure and RNA... Read More about Structure and Mechanism of Dimer-Monomer Transition of a Plant Poly(A)-Binding Protein upon RNA Interaction: Insights into Its Poly(A) Tail Assembly.

Variability in individual rates of aggression in wild gray seals: fine-scale analysis reveals importance of social and spatial stability (2015)
Journal Article
Bishop, A., Pomeroy, P., & Twiss, S. (2015). Variability in individual rates of aggression in wild gray seals: fine-scale analysis reveals importance of social and spatial stability. Behavioral Ecology and Sociobiology, 69(10), 1663-1675. https://doi.org/10.1007/s00265-015-1978-x

Aggressive interactions are costly for individuals in time, energy, or physical damage, and in polygynous mating systems, there is high variability in the rates and intensity of aggression across individuals and within breeding seasons. However, exam... Read More about Variability in individual rates of aggression in wild gray seals: fine-scale analysis reveals importance of social and spatial stability.

Coastal Upwelling Drives Intertidal Assemblage Structure and Trophic Ecology (2015)
Journal Article
Reddin, C., Docmac, F., O’Connor, N., Bothwell, J., & Harrod, C. (2015). Coastal Upwelling Drives Intertidal Assemblage Structure and Trophic Ecology. PLoS ONE, 10(7), Article e0130789. https://doi.org/10.1371/journal.pone.0130789

Similar environmental driving forces can produce similarity among geographically distant ecosystems. Coastal oceanic upwelling, for example, has been associated with elevated biomass and abundance patterns of certain functional groups, e.g., corticat... Read More about Coastal Upwelling Drives Intertidal Assemblage Structure and Trophic Ecology.

Xenopus LAP2β protein knockdown affects location of lamin B and nucleoporins and has effect on assembly of cell nucleus and cell viability (2015)
Journal Article
Dubińska-Magiera, M., Chmielewska, M., Kozioł, K., Machowska, M., Hutchison, C. J., Goldberg, M. W., & Rzepecki, R. (2015). Xenopus LAP2β protein knockdown affects location of lamin B and nucleoporins and has effect on assembly of cell nucleus and cell viability. Protoplasma, 253(3), 943-956. https://doi.org/10.1007/s00709-015-0861-y

Xenopus LAP2β protein is the single isoform expressed in XTC cells. The protein localizes on heterochromatin clusters both at the nuclear envelope and inside a cell nucleus. The majority of XLAP2β fraction neither colocalizes with TPX2 protein during... Read More about Xenopus LAP2β protein knockdown affects location of lamin B and nucleoporins and has effect on assembly of cell nucleus and cell viability.

No consistent legacy effects of invasion by Giant Goldenrod (Solidago gigantea) via soil biota on native plant growth (2015)
Journal Article
König, J., van Kleunen, M., & Dawson, W. (2015). No consistent legacy effects of invasion by Giant Goldenrod (Solidago gigantea) via soil biota on native plant growth. Journal of Plant Ecology, https://doi.org/10.1093/jpe/rtv054

Aims Changes in soil microbial communities after occupation by invasive alien plants can represent legacy effects of invasion that may limit recolonization and establishment of native plant species in soils previously occupied by the invader. In this... Read More about No consistent legacy effects of invasion by Giant Goldenrod (Solidago gigantea) via soil biota on native plant growth.

The role of protein-ligand contacts in allosteric regulation of the Escherichia coli Catabolite Activator Protein (2015)
Journal Article
Townsend, P., Rodgers, T., Glover, L., Korhonen, H., Richards, S., Colwell, L., …Cann, M. (2015). The role of protein-ligand contacts in allosteric regulation of the Escherichia coli Catabolite Activator Protein. Journal of Biological Chemistry, 290(36), 22225-22235. https://doi.org/10.1074/jbc.m115.669267

Allostery is a fundamental process by which ligand binding to a protein alters its activity at a distant site. Both experimental and theoretical evidence demonstrate that allostery can be communicated through altered slow relaxation protein dynamics... Read More about The role of protein-ligand contacts in allosteric regulation of the Escherichia coli Catabolite Activator Protein.

Crystal Structure of a Hidden Protein, YcaC, a Putative Cysteine Hydrolase from Pseudomonas aeruginosa, with and without an Acrylamide Adduct (2015)
Journal Article
Grøftehauge, M., Truan, D., Vasil, A., Denny, P., Vasil, M., & Pohl, E. (2015). Crystal Structure of a Hidden Protein, YcaC, a Putative Cysteine Hydrolase from Pseudomonas aeruginosa, with and without an Acrylamide Adduct. International Journal of Molecular Sciences, 16(7), 15971-15984. https://doi.org/10.3390/ijms160715971

As part of the ongoing effort to functionally and structurally characterize virulence factors in the opportunistic pathogen Pseudomonas aeruginosa, we determined the crystal structure of YcaC co-purified with the target protein at resolutions of 2.34... Read More about Crystal Structure of a Hidden Protein, YcaC, a Putative Cysteine Hydrolase from Pseudomonas aeruginosa, with and without an Acrylamide Adduct.

Functional Analysis of Periplakin and Envoplakin, Cytoskeletal Linkers, and Cornified Envelope Precursor Proteins (2015)
Book Chapter
Boczonadi, V., & Määttä, A. (2016). Functional Analysis of Periplakin and Envoplakin, Cytoskeletal Linkers, and Cornified Envelope Precursor Proteins. In K. Wilson, & A. Sonnenberg (Eds.), Intermediate Filament Associated Proteins (309-329). Elsevier. https://doi.org/10.1016/bs.mie.2015.06.019

A Charge Swap mutation E461K in the yeast dynamin Vps1 reduces endocytic invagination (2015)
Journal Article
Palmer, S., Smaczynska-de Rooij, I., Marklew, C., Allwood, E., Mishra, R., Goldberg, M., & Ayscough, K. (2015). A Charge Swap mutation E461K in the yeast dynamin Vps1 reduces endocytic invagination. Communicative and Integrative Biology, 8(4), https://doi.org/10.1080/19420889.2015.1051274

Vps1 is the yeast dynamin-like protein that functions during several membrane trafficking events including traffic from Golgi to vacuole, endosomal recycling and endocytosis. Vps1 can also function in peroxisomal fission indicating that its ability t... Read More about A Charge Swap mutation E461K in the yeast dynamin Vps1 reduces endocytic invagination.

A dimensionless ordered pull-through model of the mammalian lens epithelium evidences scaling across species and explains the age-dependent changes in cell density in the human lens (2015)
Journal Article
Wu, J., Wu, W., Tholozan, F., Saunter, C., Girkin, J., & Quinlan, R. (2015). A dimensionless ordered pull-through model of the mammalian lens epithelium evidences scaling across species and explains the age-dependent changes in cell density in the human lens. Journal of the Royal Society. Interface, 12(108), https://doi.org/10.1098/rsif.2015.0391

We present a mathematical (ordered pull-through; OPT) model of the cell-density profile for the mammalian lens epithelium together with new experimental data. The model is based upon dimensionless parameters, an important criterion for inter-species... Read More about A dimensionless ordered pull-through model of the mammalian lens epithelium evidences scaling across species and explains the age-dependent changes in cell density in the human lens.

International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors (2015)
Journal Article
Panula, P., Chazot, P., Cowart, M., Gutzmer, R., Leurs, R., Liu, W., …Haas, H. (2015). International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors. Pharmacological Reviews, 67(3), 601-655. https://doi.org/10.1124/pr.114.010249

Histamine is a developmentally highly conserved autacoid found in most vertebrate tissues. Its physiological functions are mediated by four 7-transmembrane G protein–coupled receptors (H1R, H2R, H3R, H4R) that are all targets of pharmacological inter... Read More about International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors.

PRC2 represses dedifferentiation of mature somatic cells in Arabidopsis (2015)
Journal Article
Ikeuchi, M., Iwase, A., Rymen, B., Harashima, H., Shibata, M., Ohnuma, M., …Sugimoto, K. (2015). PRC2 represses dedifferentiation of mature somatic cells in Arabidopsis. Nature Plants, 1(7), Article 15089. https://doi.org/10.1038/nplants.2015.89

Plant somatic cells are generally acknowledged to retain totipotency, the potential to develop into any cell type within an organism. This astonishing plasticity may contribute to a high regenerative capacity on severe damage, but how plants control... Read More about PRC2 represses dedifferentiation of mature somatic cells in Arabidopsis.

Challenging the view that invasive non-native plants are not a significant threat to the floristic diversity of Great Britain (2015)
Journal Article
Hulme, P., Pauchard, A., Pysek, P., Vila, M., Alba, C., Blackburn, T., …Winter, M. (2015). Challenging the view that invasive non-native plants are not a significant threat to the floristic diversity of Great Britain. Proceedings of the National Academy of Sciences, 112(23), E2988 - E2989. https://doi.org/10.1073/pnas.1506517112

Conservation scientists and practitioners have long recognized that not all non-native species pose a threat to biodiversity, yet some ecologists still fail to grasp this message (1). The conclusions drawn by Thomas and Palmer (2) that non-native pla... Read More about Challenging the view that invasive non-native plants are not a significant threat to the floristic diversity of Great Britain.

Quantifying landscape-level methane fluxes in subarctic Finland using a multi-scale approach (2015)
Journal Article
Hartley, I., Hill, T., Wade, T., Clement, R., Moncrieff, J., Prieto-Blanco, A., …Baxter, R. (2015). Quantifying landscape-level methane fluxes in subarctic Finland using a multi-scale approach. Global Change Biology, 21(10), 3712-3725. https://doi.org/10.1111/gcb.12975

Quantifying landscape-scale methane (CH4) fluxes from boreal and arctic regions, and determining how they are controlled, is critical for predicting the magnitude of any CH4 emission feedback to climate change. Furthermore, there remains uncertainty... Read More about Quantifying landscape-level methane fluxes in subarctic Finland using a multi-scale approach.

Generating a metal-responsive transcriptional regulator to test what confers metal-sensing in cells (2015)
Journal Article
Osman, D., Piergentili, C., Chen, J., Chakrabarti, B., Foster, A., Lurie-Luke, E., …Robinson, N. (2015). Generating a metal-responsive transcriptional regulator to test what confers metal-sensing in cells. Journal of Biological Chemistry, 290(32), 19806-19822. https://doi.org/10.1074/jbc.m115.663427

FrmR from Salmonella enterica serovar typhimurium (a CsoR/RcnR-like transcriptional de-repressor) is shown to repress the frmRA operator-promoter, and repression is alleviated by formaldehyde but not manganese, iron, cobalt, nickel, copper, or Zn(II)... Read More about Generating a metal-responsive transcriptional regulator to test what confers metal-sensing in cells.

Conspecific recognition and aggression reduction to familiars in newly weaned, socially plastic mammals (2015)
Journal Article
Robinson, K., Twiss, S., Hazon, N., Moss, S., Lonergan, M., & Pomeroy, P. (2015). Conspecific recognition and aggression reduction to familiars in newly weaned, socially plastic mammals. Behavioral Ecology and Sociobiology, 69(8), 1383-1394. https://doi.org/10.1007/s00265-015-1952-7

Recognising conspecifics and behaving appropriately towards them is a crucial ability for many species. Grey seals (Halichoerus grypus) show varying capabilities in this regard: mother-pup recognition has been demonstrated in some geographical popula... Read More about Conspecific recognition and aggression reduction to familiars in newly weaned, socially plastic mammals.

Analysing the oviposition behaviour of malaria mosquitoes: design considerations for improving two-choice egg count experiments (2015)
Journal Article
Okal, M., Lindh, J., Torr, S., Masinde, E., Orindi, B., Lindsay, S., & Fillinger, U. (2015). Analysing the oviposition behaviour of malaria mosquitoes: design considerations for improving two-choice egg count experiments. Malaria Journal, 14, Article 250. https://doi.org/10.1186/s12936-015-0768-2

Background Choice egg-count bioassays are a popular tool for analysing oviposition substrate preferences of gravid mosquitoes. This study aimed at improving the design of two-choice experiments for measuring oviposition substrates preferences of the... Read More about Analysing the oviposition behaviour of malaria mosquitoes: design considerations for improving two-choice egg count experiments.

Integrating climate change vulnerability assessments from species distribution modelling and traits based approaches. (2015)
Journal Article
Willis, S., Foden, W., Baker, D., Belle, E., Burgess, N., Carr, J., …Butchart, S. (2015). Integrating climate change vulnerability assessments from species distribution modelling and traits based approaches. Biological Conservation, 190, 167-178. https://doi.org/10.1016/j.biocon.2015.05.001

To accommodate climate-driven changes in biological communities, conservation plans are increasingly making use of models to predict species’ responses to climate change. To date, species distribution models have been the most commonly used approach... Read More about Integrating climate change vulnerability assessments from species distribution modelling and traits based approaches..

Response of Methanogens in Arctic Sediments to Temperature and Methanogenic Substrate Availability (2015)
Journal Article
Blake, L. I., Tveit, A., Øvreås, L., Head, I. M., & Gray, N. D. (2015). Response of Methanogens in Arctic Sediments to Temperature and Methanogenic Substrate Availability. PLoS ONE, 10(6), Article e0129733. https://doi.org/10.1371/journal.pone.0129733

Although cold environments are major contributors to global biogeochemical cycles, comparatively little is known about their microbial community function, structure, and limits of activity. In this study a microcosm based approach was used to investi... Read More about Response of Methanogens in Arctic Sediments to Temperature and Methanogenic Substrate Availability.

Fully biodegradable and biocompatible emulsion template polymer scaffolds by thiol-acrylate polymerisation of polycaprolactone macropolymers (2015)
Journal Article
Johnson, D., Langford, C., Didsbury, M., Lipp, B., Przyborski, S., & Cameron, N. (2015). Fully biodegradable and biocompatible emulsion template polymer scaffolds by thiol-acrylate polymerisation of polycaprolactone macropolymers. Polymer Chemistry, 6(41), 7256-7263. https://doi.org/10.1039/c5py00721f

The emulsion templating process offers a route to highly porous polymers with well-defined morphologies. This study describes the preparation of such porous polymers (polyHIPEs) via the photopolymerization of a multi-functional thiol and polycaprolac... Read More about Fully biodegradable and biocompatible emulsion template polymer scaffolds by thiol-acrylate polymerisation of polycaprolactone macropolymers.