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The atypical ‘hippocampal’ glutamate receptor coupled to phospholipase D that controls stretch‐sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2 (2023)
Journal Article
Thompson, K. J., Watson, S., Zanato, C., Dall'Angelo, S., De Nooij, J. C., Pace‐Bonello, B., …Bewick, G. S. (2024). The atypical ‘hippocampal’ glutamate receptor coupled to phospholipase D that controls stretch‐sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2. Experimental Physiology, 109(1), 81-99. https://doi.org/10.1113/ep090761

A metabotropic glutamate receptor coupled to phospholipase D (PLD-mGluR) was discovered in the hippocampus over three decades ago. Its pharmacology and direct linkage to PLD activation are well established and indicate it is a highly atypical glutama... Read More about The atypical ‘hippocampal’ glutamate receptor coupled to phospholipase D that controls stretch‐sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2.

Electrophysiological characterisation of atrial volume receptors using ex‐vivo models of isolated rat cardiac atria (2020)
Journal Article
Campbell, T., Shenton, F., Lucking, E., Pyner, S., & Jones, J. (2020). Electrophysiological characterisation of atrial volume receptors using ex‐vivo models of isolated rat cardiac atria. Experimental Physiology, 105(12), 2190-2206. https://doi.org/10.1113/ep088972

Atrial volume receptors are a family of afferent neurons whose mechanically sensitive endings terminate in the atria, particularly at the cavo‐atrial junctions. These mechanosensors form the afferent limb of an atrial volume receptor reflex which reg... Read More about Electrophysiological characterisation of atrial volume receptors using ex‐vivo models of isolated rat cardiac atria.

Distribution and morphology of sensory and autonomic fibres in the subendocardial plexus of the rat heart (2020)
Journal Article
Shenton, F., Campbell, T., Jones, J., & Pyner, S. (2020). Distribution and morphology of sensory and autonomic fibres in the subendocardial plexus of the rat heart. Journal of Anatomy, 238(1), 36-52. https://doi.org/10.1111/joa.13284

Cardiac reflexes originating from sensory receptors in the heart ensure blood supply to vital tissues and organs in the face of constantly changing demands. Atrial volume receptors are mechanically sensitive vagal afferents which relay to the medulla... Read More about Distribution and morphology of sensory and autonomic fibres in the subendocardial plexus of the rat heart.

Transient receptor potential vanilloid type 4 is expressed in vasopressinergic neurons within the magnocellular subdivision of the rat paraventricular nucleus of the hypothalamus (2018)
Journal Article
Shenton, F., & Pyner, S. (2018). Transient receptor potential vanilloid type 4 is expressed in vasopressinergic neurons within the magnocellular subdivision of the rat paraventricular nucleus of the hypothalamus. Journal of Comparative Neurology, 526(18), 3035-3044. https://doi.org/10.1002/cne.24514

Changes in plasma osmolality can drive changes in the output from brain centres known to control cardiovascular homeostasis, such as the paraventricular nucleus of the hypothalamus (PVN). Within the PVN hypotonicity reduces the firing rate of parvoce... Read More about Transient receptor potential vanilloid type 4 is expressed in vasopressinergic neurons within the magnocellular subdivision of the rat paraventricular nucleus of the hypothalamus.

Vagal Afferents, Sympathetic Efferents and the Role of the PVN in Heart Failure (2016)
Journal Article
Shenton, F., & Pyner, S. (2016). Vagal Afferents, Sympathetic Efferents and the Role of the PVN in Heart Failure. Autonomic Neuroscience: Basic and Clinical, 199, 38-47. https://doi.org/10.1016/j.autneu.2016.08.009

Sympatho-excitation is a characteristic of cardiovascular disease including heart failure (HF). The paraventricular nucleus of the hypothalamus (PVN) is an important site for central integration of sympathetic outflow. Atrial volume receptors (AVRs)... Read More about Vagal Afferents, Sympathetic Efferents and the Role of the PVN in Heart Failure.

Altered GABAA α5 subunit expression in the hypothalamic paraventricular nucleus of hypertensive and pregnant rats (2016)
Journal Article
Cork, S., Chazot, P., & Pyner, S. (2016). Altered GABAA α5 subunit expression in the hypothalamic paraventricular nucleus of hypertensive and pregnant rats. Neuroscience Letters, 620, 148-153. https://doi.org/10.1016/j.neulet.2016.03.031

A characteristic of both hypertension and pregnancy is increased sympathetic nerve activity. The level of sympathetic activation is determined, in part, by a tonic GABAergic inhibition arising from the hypothalamic paraventricular nucleus (PVN). In h... Read More about Altered GABAA α5 subunit expression in the hypothalamic paraventricular nucleus of hypertensive and pregnant rats.

Graphene oxide nanocapsules within silanized hydrogels suitable for electrochemical pseudocapacitors (2015)
Journal Article
Kataky, R., Hadden, J., Coleman, K., Ntola, C., Chowdhury, M., Duckworth, A., …Shenton, F. (2015). Graphene oxide nanocapsules within silanized hydrogels suitable for electrochemical pseudocapacitors. Chemical Communications, 51(51), 10345-10348. https://doi.org/10.1039/c5cc00968e

Soft biocompatible gels comprised of rolled up graphene oxide nanocapsules within the pores of silanized hydrogels may be used as electrochemical pseudocapacitors with physiological glucose or KOH as a reducing agent, affording a material suitable fo... Read More about Graphene oxide nanocapsules within silanized hydrogels suitable for electrochemical pseudocapacitors.

Expression of Transient Receptor Potential channels TRPC1 and TRPV4 in venoatrial endocardium of the rat heart (2014)
Journal Article
Shenton, F., & Pyner, S. (2014). Expression of Transient Receptor Potential channels TRPC1 and TRPV4 in venoatrial endocardium of the rat heart. Neuroscience, 267, 195-204. https://doi.org/10.1016/j.neuroscience.2014.02.047

The atrial volume receptor reflex arc serves to regulate plasma volume. Atrial volume receptors located in the endocardium of the atrial wall undergo mechanical deformation as blood is returned to the atria of the heart. The mechanosensitive channel(... Read More about Expression of Transient Receptor Potential channels TRPC1 and TRPV4 in venoatrial endocardium of the rat heart.

The paraventricular nucleus and heart failure (2014)
Journal Article
Pyner, S. (2014). The paraventricular nucleus and heart failure. Experimental Physiology, 99(2), 332-339. https://doi.org/10.1113/expphysiol.2013.072678

What is the topic of this review? This review gives an update on the cellular and molecular mechanisms within the autonomic nervous system involved in non‐pathological and pathological cardiovascular regulation. What advances does it highlight? For c... Read More about The paraventricular nucleus and heart failure.

The projection and synaptic organisation of NTS afferent connections with presympathetic neurones, GABA and nNOS neurons in the paraventricular nucleus of the hypothalamus (2012)
Journal Article
Affleck, V., Coote, J., & Pyner, S. (2012). The projection and synaptic organisation of NTS afferent connections with presympathetic neurones, GABA and nNOS neurons in the paraventricular nucleus of the hypothalamus. Neuroscience, 219, 48-61. https://doi.org/10.1016/j.neuroscience.2012.05.070

Elevated sympathetic nerve activity, strongly associated with cardiovascular disease, is partly generated from the presympathetic neurons of the paraventricular nucleus of the hypothalamus (PVN). The PVN-presympathetic neurons regulating cardiac and... Read More about The projection and synaptic organisation of NTS afferent connections with presympathetic neurones, GABA and nNOS neurons in the paraventricular nucleus of the hypothalamus.

A novel low temperature transcutaneous energy transfer system suitable for high power implantable medical devices: performance and validation in sheep (2010)
Journal Article
Dissanayakee, T., Budgett, D., Hu, P., Bennet, L., Pyner, S., Booth, L., …Malpas, S. (2010). A novel low temperature transcutaneous energy transfer system suitable for high power implantable medical devices: performance and validation in sheep. Artificial Organs, 34(5), E160-E167. https://doi.org/10.1111/j.1525-1594.2009.00992.x

Transcutaneous energy transfer (TET) systems use magnetic fields to transfer power across the skin without direct electrical connectivity. This offers the prospect of lifetime operation and overcomes risk of infection associated with wires passing th... Read More about A novel low temperature transcutaneous energy transfer system suitable for high power implantable medical devices: performance and validation in sheep.

Neurochemistry of the paraventricular nucleus of the hypothalamus: Implications for cardiovascular regulation. (2009)
Journal Article
Pyner, S. (2009). Neurochemistry of the paraventricular nucleus of the hypothalamus: Implications for cardiovascular regulation. Journal of Chemical Neuroanatomy, 38(3), 197-208. https://doi.org/10.1016/j.jchemneu.2009.03.005

The paraventricular nucleus of the hypothalamus (PVN) is an important site for autonomic and endocrine homeostasis. The PVN integrates specific afferent stimuli to produce an appropriate differential sympathetic output. The neural circuitry and some... Read More about Neurochemistry of the paraventricular nucleus of the hypothalamus: Implications for cardiovascular regulation..

An immunohistochemical investigation of the relationship between neuronal nitric oxide synthase, GABA and presympathetic paraventricular neurons in the hypothalamus (2009)
Journal Article
Watkins, N., Cork, S., & Pyner, S. (2009). An immunohistochemical investigation of the relationship between neuronal nitric oxide synthase, GABA and presympathetic paraventricular neurons in the hypothalamus. Neuroscience, 159(3), 1079-1088. https://doi.org/10.1016/j.neuroscience.2009.01.012

Functional studies suggest that nitric oxide (NO) modulates sympathetic outflow by enhancing synaptic GABAergic function. Furthermore, the paraventricular nucleus of the hypothalamus (PVN), an important site for autonomic and endocrine homeostasis co... Read More about An immunohistochemical investigation of the relationship between neuronal nitric oxide synthase, GABA and presympathetic paraventricular neurons in the hypothalamus.

Inhibition by alpha-tetrahydrodeoxycorticosterone (THDOC) of pre-sympathetic parvocellular neurones in the paraventricular nucleus of rat hypothalamus. (2006)
Journal Article
Womack, M., Pyner, S., & Barrett-Jolley, R. (2006). Inhibition by alpha-tetrahydrodeoxycorticosterone (THDOC) of pre-sympathetic parvocellular neurones in the paraventricular nucleus of rat hypothalamus. British Journal of Pharmacology, 149(5), 600-607. https://doi.org/10.1038/sj.bjp.0706911

Background and Purpose: α-tetrahydrodeoxycorticosterone (THDOC) is an endogenous neuroactive steroid which increases in plasma and brain concentration during stress. It has both positive and negative modulatory effects on GABA activated GABAA current... Read More about Inhibition by alpha-tetrahydrodeoxycorticosterone (THDOC) of pre-sympathetic parvocellular neurones in the paraventricular nucleus of rat hypothalamus..

The role of free radicals in the muscle vasodilatation of systemic hypoxia in the rat (2003)
Journal Article
Pyner, S., Coney, A., & Marshall, J. (2003). The role of free radicals in the muscle vasodilatation of systemic hypoxia in the rat. Experimental Physiology, 88(6), 733-740. https://doi.org/10.1113/eph8802524

Muscle vasodilatation evoked by systemic hypoxia is adenosine mediated and nitric oxide (NO) dependent: recent evidence suggests the increased binding of NO at complex IV of endothelial mitochondria when O2 level falls leads to adenosine release. In... Read More about The role of free radicals in the muscle vasodilatation of systemic hypoxia in the rat.

Spinal cord interneurones labelled transneuronally from the adrenal gland by a GFP-herpes virus construct contain the potassium channel subunit Kv3.1b (2002)
Journal Article
Brooke, R., Pyner, S., McLeish, P., Buchan, A., Deuchars, J., & Deuchars, S. (2002). Spinal cord interneurones labelled transneuronally from the adrenal gland by a GFP-herpes virus construct contain the potassium channel subunit Kv3.1b. Autonomic Neuroscience: Basic and Clinical, 98(1-2), 45-50. https://doi.org/10.1016/s1566-0702%2802%2900030-9

Interneurones in the spinal cord are likely to play an important role in the generation of activity in sympathetic preganglionic neurones (SPNs) and, therefore, sympathetic outflow. Although the properties of these interneurones have rarely been stud... Read More about Spinal cord interneurones labelled transneuronally from the adrenal gland by a GFP-herpes virus construct contain the potassium channel subunit Kv3.1b.

Right atrial stretch induces renal nerve inhibition and c-fos expression in parvocellular neurones of the paraventricular nucleus in rats (2002)
Journal Article
Pyner, S., Deering, J., & Coote, J. (2002). Right atrial stretch induces renal nerve inhibition and c-fos expression in parvocellular neurones of the paraventricular nucleus in rats. Experimental Physiology, 87(1), 25-32. https://doi.org/10.1113/eph8702279

The paraventricular nucleus of the hypothalamus plays a pivotol role in the regulation of plasma volume. Part of the response to an increase in volume load is an inhibition of renal sympathetic nerve activity. The present experiments were designed to... Read More about Right atrial stretch induces renal nerve inhibition and c-fos expression in parvocellular neurones of the paraventricular nucleus in rats.

Tracing functionally identified neurones in a multisynaptic pathway in the hamster and rat using herpes simplex virus expressing green fluorescent protein (2001)
Journal Article
Pyner, S., Cleary, J., McLeish, P., Buchan, A., & Coote, J. (2001). Tracing functionally identified neurones in a multisynaptic pathway in the hamster and rat using herpes simplex virus expressing green fluorescent protein. Experimental Physiology, 86(6), 695-702. https://doi.org/10.1111/j.1469-445x.2001.tb00034.x

Using a genetically modified herpes simplex virus encoding green fluorescent protein we sought to establish if this viral modification could be used in transneuronal tracing studies of the sympathetic nervous system. The herpes simplex virus encoding... Read More about Tracing functionally identified neurones in a multisynaptic pathway in the hamster and rat using herpes simplex virus expressing green fluorescent protein.