All Outputs (142)

Galactose-Functionalized PolyHIPE Scaffolds for Use in Routine Three Dimensional Culture of Mammalian Hepatocytes (2013)
Journal Article
Hayward, A., Eissa, A., Maltman, D., Przyborski, S., & Cameron, N. (2013). Galactose-Functionalized PolyHIPE Scaffolds for Use in Routine Three Dimensional Culture of Mammalian Hepatocytes. Biomacromolecules, 14(12), 4271-4277. https://doi.org/10.1021/bm401145x

Three-dimensional (3D) cell culture is regarded as a more physiologically relevant method of growing cells in the laboratory compared to traditional monolayer cultures. Recently, the application of polystyrene-based scaffolds produced using polyHIPE... Read More about Galactose-Functionalized PolyHIPE Scaffolds for Use in Routine Three Dimensional Culture of Mammalian Hepatocytes.

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (2013)
Journal Article
Godoy, P., Hewitt, N., Albrecht, U., Andersen, M., Ansari, N., Bhattacharya, S., …Hengstler, J. (2013). Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Archives of Toxicology, 87(8), 1315-1530. https://doi.org/10.1007/s00204-013-1078-5

This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, zonated lobules, the liver consists of approximately 80 % hepatocyte... Read More about Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

Human mesenchymal stem cells creating an immunosuppressive environment and promote breast cancer in mice (2013)
Journal Article
Ljujic, B., Milovanovic, M., Volarevic, V., Murray, B., Bugarski, D., Przyborski, S., …Stojkovic, M. (2013). Human mesenchymal stem cells creating an immunosuppressive environment and promote breast cancer in mice. Scientific Reports, 3, Article 2298. https://doi.org/10.1038/srep02298

Human mesenchymal stem cells (hMSC) can home to tumor sites and promote tumor growth. The effects of hMSC on tumor growth are controversial and involvement of hMSC in tumor immunology has not been adequately addressed. Therefore, we investigated whet... Read More about Human mesenchymal stem cells creating an immunosuppressive environment and promote breast cancer in mice.

Synthesis and applications of 2,4-disubstituted thiazoles derivatives as small molecule modulators of cellular development (2013)
Journal Article
Zhou, G., Tams, D., Marder, T., Valentine, R., Whiting, A., & Przyborski, S. (2013). Synthesis and applications of 2,4-disubstituted thiazoles derivatives as small molecule modulators of cellular development. Organic and Biomolecular Chemistry, 11(14), 2323-2334. https://doi.org/10.1039/c3ob00005b

Understanding how the structure of molecules relates to their function and biological activity is essential in the development of new analogues with targeted activity. This is especially relevant in mediating developmental processes in mammalian cell... Read More about Synthesis and applications of 2,4-disubstituted thiazoles derivatives as small molecule modulators of cellular development.

The action of all-trans-retinoic acid (ATRA) and synthetic retinoid analogues (EC19 and EC23) on human pluripotent stem cells differentiation investigated using single cell infrared microspectroscopy (2013)
Journal Article
Clemens, G., Flower, K., Henderson, A., Whiting, A., Przyborski, S., Jimenez-Hernandez, M., …Gardner, P. (2013). The action of all-trans-retinoic acid (ATRA) and synthetic retinoid analogues (EC19 and EC23) on human pluripotent stem cells differentiation investigated using single cell infrared microspectroscopy. Molecular bioSystems, 9(4), 677-692. https://doi.org/10.1039/c3mb25505k

All trans-retinoic acid (ATRA) is widely used to direct the differentiation of cultured stem cells. When exposed to the pluripotent human embryonal carcinoma (EC) stem cell line, TERA2.cl.SP12, ATRA induces ectoderm differentiation and the formation... Read More about The action of all-trans-retinoic acid (ATRA) and synthetic retinoid analogues (EC19 and EC23) on human pluripotent stem cells differentiation investigated using single cell infrared microspectroscopy.

Generation of proliferating human hepatocytes using upcyte technology: characterisation and applications in induction and cytotoxicity assays (2012)
Journal Article
Burkard, A., Dahn, C., Heinz, S., Zutavern, A., Sonntag-Buck, V., Maltman, D., …Braspenning, J. (2012). Generation of proliferating human hepatocytes using upcyte technology: characterisation and applications in induction and cytotoxicity assays. Xenobiotica, 42, 939-956

Top-down label-free LC-MALDI analysis of the peptidome during neural progenitor cell differentiation reveals complexity in cytoskeletal protein dynamics and identifies progenitor cell markers (2011)
Journal Article
Maltman, D., Brand, S., Belau, E., Paape, R., Suckau, D., & Przyborski, S. (2011). Top-down label-free LC-MALDI analysis of the peptidome during neural progenitor cell differentiation reveals complexity in cytoskeletal protein dynamics and identifies progenitor cell markers. Proteomics, 11(20), 3992-4006. https://doi.org/10.1002/pmic.201100024

Alvetex®: polystyrene scaffold technology for routine three dimensional cell culture. (2011)
Journal Article
Knight, E., Murray, B., Carnachan, R., & Przyborski, S. (2011). Alvetex®: polystyrene scaffold technology for routine three dimensional cell culture

Alvetex: technology for routine three dimensional cell culture (2010)
Book
Przyborski, S. (2010). Alvetex: technology for routine three dimensional cell culture. Humana Press

Validation of reference gene stability for APAP hepatotoxicity studies in different in vitro systems and identification of novel potential toxicity biomarkers (2010)
Journal Article
Fox, B., Devonshire, A., Schutte, M., Foy, C., Minguez, J., Przyborski, S., …Marshall, D. (2010). Validation of reference gene stability for APAP hepatotoxicity studies in different in vitro systems and identification of novel potential toxicity biomarkers. Toxicology in Vitro, 24(7), 1962-1970

Neural differentiation regulated by biomimetic surfaces presenting motifs of extracellular matrix proteins (2010)
Journal Article
Cooke, M., Zahir, T., Phillips, S., Shah, D., Athey, D., Lakey, J., …Przyborski, S. (2010). Neural differentiation regulated by biomimetic surfaces presenting motifs of extracellular matrix proteins. Journal of Biomedical Materials Research Part A, 93A(3), 824-832. https://doi.org/10.1002/jbm.a.32585

Lamins as cancer biomarkers (2010)
Journal Article
Foster, C., Przyborski, S., Wilson, R., & Hutchison, C. (2010). Lamins as cancer biomarkers. Biochemical Society Transactions, 38(1), 297-300. https://doi.org/10.1042/bst0380297

Developments in three dimensional cell culture technology aimed at improving the accuracy of in vitro analyses (2010)
Journal Article
Maltman, D., & Przyborski, S. (2010). Developments in three dimensional cell culture technology aimed at improving the accuracy of in vitro analyses. Biochemical Society Transactions, 38(4), 1072-1075

Human induced pluripotent stem cell line shows similar stress defense mechanisms and mitochondrial regulation to human embryonic stem cells (2010)
Journal Article
Armstrong, L., Tilgner, K., Saretzki, G., Atkinson, S., Stojkovic, M., Moreno, R., …Lako, M. (2010). Human induced pluripotent stem cell line shows similar stress defense mechanisms and mitochondrial regulation to human embryonic stem cells. Stem Cells, 28, 661-673

Retinoid supplementation of differentiating human neural progenitors and embryonic stem cells leads to enhanced neurogenesis in vitro. (2010)
Journal Article
Christie, V., Maltman, D., Henderson, A., Whiting, A., Marder, T., Lako, M., & Przyborski, S. (2010). Retinoid supplementation of differentiating human neural progenitors and embryonic stem cells leads to enhanced neurogenesis in vitro. Journal of Neuroscience Methods, 193(2), 239-245

The development of small molecules and growth supplements to control the differentiation of stem cells and the formation of neural tissues (2010)
Book Chapter
Christie, V., Maltman, D., Whiting, A., Marder, T., & Przyborski, S. (2010). The development of small molecules and growth supplements to control the differentiation of stem cells and the formation of neural tissues. In K. Appasani (Ed.), Stem Cells and Regenerative Medicine. Springer Publishing Company

Mesenchymal stem cells and their therapeutic applications (2010)
Book Chapter
Hardy, S., Maltman, D., & Przyborski, S. (2010). Mesenchymal stem cells and their therapeutic applications. In S. Totey, & K. Deb (Eds.), Stem Cells: Basics and Applications. McGraw-Hill

NANOG regulates S pahse entry and progression in human embryonic stem cells through activation of CDK6 and CD25A (2009)
Journal Article
Zhang, X., Neganova, I., Przyborski, S., Yang, C., Cooke, M., Atkinson, S., …Lako, M. (2009). NANOG regulates S pahse entry and progression in human embryonic stem cells through activation of CDK6 and CD25A. Journal of Cell Biology, 184, 67-82

Synthetic retinoids: structure-activity relationships (2009)
Journal Article
Barnard, J., Collings, J., Whiting, A., Przyborski, S., & Marder, T. (2009). Synthetic retinoids: structure-activity relationships

A putative role for RHAMM/HMMR as a negative marker of stem cell-containing population of human limbal epithelial cells (2009)
Journal Article
Ahmad, S., Kolli, S., Li, D., Paiva, C., Przyborski, S., Dimmick, I., …Lako, M. (2009). A putative role for RHAMM/HMMR as a negative marker of stem cell-containing population of human limbal epithelial cells. Stem Cells, 26, 1609-1619