All Outputs (3)

A robust and reproducible human pluripotent stem cell derived model of neurite outgrowth in a three-dimensional culture system and its application to study neurite inhibition (2016)
Journal Article
Clarke, K., Tams, D., Henderson, A., Roger, M., Whiting, A., & Przyborski, S. (2016). A robust and reproducible human pluripotent stem cell derived model of neurite outgrowth in a three-dimensional culture system and its application to study neurite inhibition. Neurochemistry International, 106, 74-84. https://doi.org/10.1016/j.neuint.2016.12.009

The inability of neurites to grow and restore neural connections is common to many neurological disorders, including trauma to the central nervous system and neurodegenerative diseases. Therefore, there is need for a robust and reproducible model of... Read More about A robust and reproducible human pluripotent stem cell derived model of neurite outgrowth in a three-dimensional culture system and its application to study neurite inhibition.

Histone demethylation and toll‐like receptor 8–dependent cross‐talk in monocytes promotes transdifferentiation of fibroblasts in systemic sclerosis via Fra‐2 (2016)
Journal Article
Ciechomska, M., O'Reilly, S., Przyborski, S., Oakley, F., Bogunia-Kubik, K., & van Laar, J. (2016). Histone demethylation and toll‐like receptor 8–dependent cross‐talk in monocytes promotes transdifferentiation of fibroblasts in systemic sclerosis via Fra‐2. Arthritis and Rheumatology, 68(6), 1493-1504. https://doi.org/10.1002/art.39602

Objectives: To investigate whether epigenetic changes can modulate monocytes to produce tissue-inhibitor of metalloproteinase-1 (TIMP-1) via Fra2 (AP-1 family member), a novel downstream mediator promoting fibrogenesis. Methods: AP-1 transcription fa... Read More about Histone demethylation and toll‐like receptor 8–dependent cross‐talk in monocytes promotes transdifferentiation of fibroblasts in systemic sclerosis via Fra‐2.

IL-13 mediates collagen deposition via STAT6 and microRNA-135b: a role for epigenetics (2016)
Journal Article
O’Reilly, S., Ciechomska, M., Fullard, N., Przyborski, S., & van Laar, J. (2016). IL-13 mediates collagen deposition via STAT6 and microRNA-135b: a role for epigenetics. Scientific Reports, 6, Article 25066. https://doi.org/10.1038/srep25066

Systemic sclerosis is an autoimmune connective tissue disease in which T cells play a prominent role. We and others have previously demonstrated a role for T cell-derived IL-13 in mediating the induction of collagen in dermal fibroblasts and that blo... Read More about IL-13 mediates collagen deposition via STAT6 and microRNA-135b: a role for epigenetics.