All Outputs (7)

A new dawn for cataracts (2015)
Journal Article
Quinlan, R. (2015). A new dawn for cataracts. Science, 350(6261), 636-637. https://doi.org/10.1126/science.aad6303

Cataract, a clouding of the eye lens, is the major cause of blindness in the world, accounting for about 20 million cases (1). Treatment is surgical—the opaque, cataractous lens is replaced with an artificial, plastic one. Many people in the developi... Read More about A new dawn for cataracts.

In vivo, Ex Vivo, and In VitroApproaches to Study IntermediateFilaments in the Eye Lens (2015)
Journal Article
Jarrin, M., Young, L., Wu, W., Girkin, J., & Quinlan, R. (2016). In vivo, Ex Vivo, and In VitroApproaches to Study IntermediateFilaments in the Eye Lens. Methods in enzymology, 568, 581-611. https://doi.org/10.1016/bs.mie.2015.09.010

The role of the eye lens is to focus light into the retina. To perform this unique function, the ocular lens must be transparent. Previous studies have demonstrated the expression of vimentin, BFSP1, and BFSP2 in the eye lens. These intermediate fila... Read More about In vivo, Ex Vivo, and In VitroApproaches to Study IntermediateFilaments in the Eye Lens.

Purification of Protein Chaperones and Their Functional Assays with Intermediate Filaments. (2015)
Book Chapter
Perng, M., Huang, Y., & Quinlan, R. (2016). Purification of Protein Chaperones and Their Functional Assays with Intermediate Filaments. In A. Sonnenberg, & K. Wilson (Eds.), Intermediate Filament Associated Proteins (155-175). Elsevier. https://doi.org/10.1016/bs.mie.2015.07.025

A dimensionless ordered pull-through model of the mammalian lens epithelium evidences scaling across species and explains the age-dependent changes in cell density in the human lens (2015)
Journal Article
Wu, J., Wu, W., Tholozan, F., Saunter, C., Girkin, J., & Quinlan, R. (2015). A dimensionless ordered pull-through model of the mammalian lens epithelium evidences scaling across species and explains the age-dependent changes in cell density in the human lens. Journal of the Royal Society. Interface, 12(108), https://doi.org/10.1098/rsif.2015.0391

We present a mathematical (ordered pull-through; OPT) model of the cell-density profile for the mammalian lens epithelium together with new experimental data. The model is based upon dimensionless parameters, an important criterion for inter-species... Read More about A dimensionless ordered pull-through model of the mammalian lens epithelium evidences scaling across species and explains the age-dependent changes in cell density in the human lens.

The lens of the eye: exposures in the UK medical sector and mechanistic studies of radiation effects (2015)
Journal Article
Bouffler, S., Peters, S., Gilvin, P., Slack, K., Markiewicz, E., Quinlan, R., …Ainsbury, E. (2015). The lens of the eye: exposures in the UK medical sector and mechanistic studies of radiation effects. Annals of the ICRP, 44(1 Suppl), 84-90. https://doi.org/10.1177/0146645314560693

The recommendation from the International Commission on Radiological Protection that the occupational equivalent dose limit for the lens of the eye should be reduced to 20 mSv year−1, averaged over 5 years with no year exceeding 50 mSv, has stimulate... Read More about The lens of the eye: exposures in the UK medical sector and mechanistic studies of radiation effects.

Nonlinear ionizing radiation-induced changes in eye lens cell proliferation, cyclin D1 expression and lens shape (2015)
Journal Article
Markiewicz, E., Barnard, S., Haines, J., Coster, M., Geel, O. V., Wu, W., …Quinlan, R. A. (2015). Nonlinear ionizing radiation-induced changes in eye lens cell proliferation, cyclin D1 expression and lens shape. Open Biology, 5, Article 150011. https://doi.org/10.1098/rsob.150011

Elevated cataract risk after radiation exposure was established soon after the discovery of X-rays in 1895. Today, increased cataract incidence among medical imaging practitioners and after nuclear incidents has highlighted how little is still unders... Read More about Nonlinear ionizing radiation-induced changes in eye lens cell proliferation, cyclin D1 expression and lens shape.

A silk purse from a sow’s ear – bioinspired materials based on α-helical coiled coils (2015)
Journal Article
Quinlan, R., Bromley, E., & Pohl, E. (2015). A silk purse from a sow’s ear – bioinspired materials based on α-helical coiled coils. Current Opinion in Cell Biology, 32, 131-137. https://doi.org/10.1016/j.ceb.2014.12.010

This past few years have heralded remarkable times for intermediate filaments with new revelations of their structural properties that has included the first crystallographic-based model of vimentin to build on the experimental data of intra-filament... Read More about A silk purse from a sow’s ear – bioinspired materials based on α-helical coiled coils.