All Outputs (2)

Biocatalytic synthesis of ribonucleoside analogues using nucleoside transglycosylase-2 (2024)
Journal Article
Salihovic, A., Ascham, A., Rosenqvist, P. S., Taladriz-Sender, A., Hoskisson, P. A., Hodgson, D. R. W., Grogan, G., & Burley, G. A. (2025). Biocatalytic synthesis of ribonucleoside analogues using nucleoside transglycosylase-2. Chemical Science, 16(3), 1302-1307. https://doi.org/10.1039/d4sc07521h

Ribonucleosides are essential building blocks used extensively in antiviral and oligonucleotide therapeutics. A major challenge in the further development of nucleoside analogues for therapeutic applications is access to scalable and environmentally... Read More about Biocatalytic synthesis of ribonucleoside analogues using nucleoside transglycosylase-2.

Probing the nucleobase selectivity of RNA polymerases with dual-coding substrates (2024)
Journal Article
Mäkinen, J. J., Rosenqvist, P., Virta, P., Metsä-Ketelä, M., & Belogurov, G. A. (2024). Probing the nucleobase selectivity of RNA polymerases with dual-coding substrates. Journal of Biological Chemistry, 300(10), Article 107755. https://doi.org/10.1016/j.jbc.2024.107755

Formycin A (FOR) and pyrazofurin A (PYR) are nucleoside analogs with antiviral and antitumor properties. They are known to interfere with nucleic acid metabolism, but their direct effect on transcription is less understood. We explored how RNA polyme... Read More about Probing the nucleobase selectivity of RNA polymerases with dual-coding substrates.