All Outputs (3)

Rationalized Computer-Aided design of Matrix Metalloprotease-Selective Prodrugs (2017)
Journal Article
Jain, M., Harburn, J., Gill, J., Loadman, P., Falconer, R., Mooney, C., …Berry, D. (2017). Rationalized Computer-Aided design of Matrix Metalloprotease-Selective Prodrugs. Journal of Medicinal Chemistry, 60(10), 4496-4502. https://doi.org/10.1021/acs.jmedchem.6b01472

Matrix metalloproteinases (MMPs) are central to cancer development and metastasis. They are highly active in the tumour environment and absent or inactive in normal tissues; therefore they represent viable targets for cancer drug discovery. In this s... Read More about Rationalized Computer-Aided design of Matrix Metalloprotease-Selective Prodrugs.

Ethanol-Based Proliposome Delivery Systems of Paclitaxel for In Vitro Application Against Brain Cancer Cells (2016)
Journal Article
Najlah, M., Jain, M., Wan, K., Ahmed, W., Alhnan, M., Phoenix, D., …Elhissi, A. (2018). Ethanol-Based Proliposome Delivery Systems of Paclitaxel for In Vitro Application Against Brain Cancer Cells. Journal of Liposome Research, 28(1), 74-85. https://doi.org/10.1080/08982104.2016.1259628

In this study the anticancer activity of paclitaxel-loaded nano-liposomes on glioma cell lines was investigated. Soya phosphatidylcholine:cholesterol (SPC:Chol), hydrogenated soya phosphatidylcholine:cholesterol (HSPC:Chol) or dipalmitoylphosphatidyl... Read More about Ethanol-Based Proliposome Delivery Systems of Paclitaxel for In Vitro Application Against Brain Cancer Cells.

Pyridylphosphinate Metal Complexes: Synthesis, Structural Characterisation and Biological Activity (2016)
Journal Article
Cross, J., Gallagher, N., Gill, J., Jain, M., McNeillis, A., Rockley, K., …Walton, J. (2016). Pyridylphosphinate Metal Complexes: Synthesis, Structural Characterisation and Biological Activity. Dalton Transactions, 45(32), 12807-12813. https://doi.org/10.1039/c6dt01264g

For the first time, a series of 25 pseudo-octahedral pyridylphosphinate metal complexes (Ru, Os, Rh, Ir) has been synthesised and assessed in biological systems. Each metal complex incorporates a pyridylphosphinate ligand, a monodentate halide and a... Read More about Pyridylphosphinate Metal Complexes: Synthesis, Structural Characterisation and Biological Activity.