All Outputs (47)

The Unfolded Protein Response: An Overview (2021)
Journal Article
Read, A., & Schröder, M. (2021). The Unfolded Protein Response: An Overview. Biology, 10(5), Article 384. https://doi.org/10.3390/biology10050384

The unfolded protein response is the mechanism by which cells control endoplasmic reticulum (ER) protein homeostasis. Under normal conditions, the UPR is not activated; however, under certain stresses, such as hypoxia or altered glycosylation, the UP... Read More about The Unfolded Protein Response: An Overview.

Endoplasmic reticulum stress causes insulin resistance by inhibiting delivery of newly synthesised insulin receptors to the cell surface (2020)
Journal Article
Brown, M., Dainty, S., Strudwick, N., Mihai, A. D., Watson, J. N., Dendooven, R., Paton, A. W., Paton, J. C., & Schröder, M. (2020). Endoplasmic reticulum stress causes insulin resistance by inhibiting delivery of newly synthesised insulin receptors to the cell surface. Molecular Biology of the Cell, 31(23), 2495-2629. https://doi.org/10.1091/mbc.e18-01-0013

Accumulation of unfolded proteins in the endoplasmic reticulum (ER) causes ER stress and activates a signalling network known as the unfolded protein response (UPR). Here we characterise how ER stress and the UPR inhibit insulin signalling. We find t... Read More about Endoplasmic reticulum stress causes insulin resistance by inhibiting delivery of newly synthesised insulin receptors to the cell surface.

Bypass of activation loop phosphorylation by aspartate 836 in activation of the endoribonuclease activity of Ire1 (2017)
Journal Article
Armstrong, M., Sestak, S., Ali, A., Sagini, H., Brown, M., Baty, K., …Schröder, M. (2017). Bypass of activation loop phosphorylation by aspartate 836 in activation of the endoribonuclease activity of Ire1. Molecular and Cellular Biology, 37(16), e00655-16. https://doi.org/10.1128/mcb.00655-16

The bifunctional protein kinase-endoribonuclease Ire1 initiates splicing of the mRNA for the transcription factor Hac1 when unfolded proteins accumulate in the endoplasmic reticulum. Activation of Saccharomyces cerevisiae Ire1 coincides with autophos... Read More about Bypass of activation loop phosphorylation by aspartate 836 in activation of the endoribonuclease activity of Ire1.

An initial phase of JNK activation inhibits cell death early in the endoplasmic reticulum stress response (2016)
Journal Article
Brown, M., Strudwick, N., Suwara, M., Sutcliffe, L., Mihai, A., Ali, A., …Schröder, M. (2016). An initial phase of JNK activation inhibits cell death early in the endoplasmic reticulum stress response. Journal of Cell Science, 129(12), 2317-2328. https://doi.org/10.1242/jcs.179127

Accumulation of unfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR). In mammalian cells, UPR signals generated by several ER membrane resident proteins, including the bifunctional protein kinase endoribon... Read More about An initial phase of JNK activation inhibits cell death early in the endoplasmic reticulum stress response.

Glucose starvation and hypoxia, but not the saturated fatty acid palmitic acid or cholesterol, activate the unfolded protein response in 3T3-F442A and 3T3-L1 adipocytes (2015)
Journal Article
Mihai, A., & Schröder, M. (2015). Glucose starvation and hypoxia, but not the saturated fatty acid palmitic acid or cholesterol, activate the unfolded protein response in 3T3-F442A and 3T3-L1 adipocytes. Adipocyte, 4(3), 188-202. https://doi.org/10.4161/21623945.2014.989728

Obesity is associated with endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR) in adipose tissue. In this study we identify physiological triggers of ER stress and of the UPR in adipocytes in vitro. We show that tw... Read More about Glucose starvation and hypoxia, but not the saturated fatty acid palmitic acid or cholesterol, activate the unfolded protein response in 3T3-F442A and 3T3-L1 adipocytes.

5’-Deoxy-5’-hydrazinylguanosine as an initiator of T7 RNA polymerase-catalyzed transcriptions for the preparation of labeling-ready RNAs (2013)
Journal Article
Skipsey, M., Hack, G., Hooper, T., Shankey, M., Conway, L., Schröder, M., & Hodgson, D. (2013). 5’-Deoxy-5’-hydrazinylguanosine as an initiator of T7 RNA polymerase-catalyzed transcriptions for the preparation of labeling-ready RNAs. Nucleosides, Nucleotides and Nucleic Acids, 32(12), 670-681. https://doi.org/10.1080/15257770.2013.851393

5′-deoxy-5′-hydrazinylguanosine was incorporated into the 5′-termini of RNA transcripts using T7 RNA polymerase. Transcriptions provided 5′-hydrazinyl-RNA that was readily labeled and purified. The use of fluorophore-labeled material was validated in... Read More about 5’-Deoxy-5’-hydrazinylguanosine as an initiator of T7 RNA polymerase-catalyzed transcriptions for the preparation of labeling-ready RNAs.

Chemical approaches twoards unraveling kinase-mediated signaling pathways (2011)
Journal Article
Hodgson, D., & Schröder, M. (2011). Chemical approaches twoards unraveling kinase-mediated signaling pathways. Chemical Society Reviews, 40(3), 1211-1223

Measuring signaling by the unfolded protein response. (2011)
Journal Article
Cox, D., Srudwick, N., Ali, A., Paton, A., Paton, J., & Schröder, M. (2011). Measuring signaling by the unfolded protein response. Methods in enzymology, 491, 261-292. https://doi.org/10.1016/b978-0-12-385928-0.00015-8

Consequences of stress in the secretory pathway: the ER stress response and its role in the metabolic syndrome. (2010)
Journal Article
Schröder, M., & Sutcliffe, L. (2010). Consequences of stress in the secretory pathway: the ER stress response and its role in the metabolic syndrome. Methods in molecular biology (Clifton, N.J. Online), 648, 43-62. https://doi.org/10.1007/978-1-60761-756-3_3

Molecular chaperones of the endoplasmic reticulum (2010)
Book
Schröder, M. (2010). Molecular chaperones of the endoplasmic reticulum. Nova Science Publishers

Ime1 and Ime2 are required for pseudohyphal growth of Saccharomyces cerevisiae on Nonfermentable Carbon Sources. (2010)
Journal Article
Strudwick, N., Brown, M., Parmar, V., & Schröder, M. (2010). Ime1 and Ime2 are required for pseudohyphal growth of Saccharomyces cerevisiae on Nonfermentable Carbon Sources. Molecular and Cellular Biology, 30(23), 5514-5530. https://doi.org/10.1128/mcb.00390-10

Molecular chaperones of the endoplasmic reticulum (2009)
Book Chapter
Schröder, M. (2009). Molecular chaperones of the endoplasmic reticulum. In P. Durante, & L. Colucci (Eds.), Handbook of Molecular Chaperones: Roles, Structures and Mechanisms (1-78). Nova Science Publishers

Unfolded protein response (2008)
Book Chapter
Schröder, M. (2008). Unfolded protein response. In J. Weil, D. Blumel, S. Malmoli, & J. Netting (Eds.), Yearbook of Science and Technology (356-360). McGraw-Hill

Endoplasmic reticulum stress responses (2008)
Journal Article
Schröder, M. (2008). Endoplasmic reticulum stress responses. Cellular and Molecular Life Sciences, 65(6), 862-894. https://doi.org/10.1007/s00018-007-7383-5

In homeostasis, cellular processes are in a dynamic equilibrium. Perturbation of homeostasis causes stress. In this review I summarize how perturbation of three major functions of the endoplasmic reticulum (ER) in eukaryotic cells-protein folding, li... Read More about Endoplasmic reticulum stress responses.

Engineering of chaperone systems and of the unfolded protein response (2008)
Journal Article
Khan, S., & Schröder, M. (2008). Engineering of chaperone systems and of the unfolded protein response. Cytotechnology, 57(3), 207-231. https://doi.org/10.1007/s10616-008-9157-9

Production of recombinant proteins in mammalian cells is a successful technology that delivers protein pharmaceuticals for therapies and for diagnosis of human disorders. Cost effective production of protein biopharmaceuticals requires extensive opti... Read More about Engineering of chaperone systems and of the unfolded protein response.

Engineering eukaryotic protein factories (2008)
Journal Article
Schröder, M. (2008). Engineering eukaryotic protein factories. Biotechnology Letters, 30(2), 187-196. https://doi.org/10.1007/s10529-007-9524-1

The biopharmaceuticals market is currently outperforming the pharmaceuticals market and is now valued at US$ 48 billion with an average annual growth of 19%. Behind this success is a 100-fold increase in productivities of eukaryotic expression system... Read More about Engineering eukaryotic protein factories.

Isolierung von RNA (2007)
Book Chapter
Schröder, M. (2007). Isolierung von RNA. In M. Jansohn (Ed.), Gentechnische Methoden (131-154). Elsevier

The unfolded protein response (2007)
Book Chapter
Strudwick, N., & Schröder, M. (2007). The unfolded protein response. In M. Al-Rubeai, & M. Fussenegger (Eds.), Cell Engineering Vol 5: Systems Biology (69-157). Springer Netherlands

Protein folding is the rate-limiting step for secretion of recombinant proteins in nearly all expression systems. Overexpression of recombinant proteins easily exhausts the cellular protein folding machinery in the endoplasmic reticulum (ER). In this... Read More about The unfolded protein response.

The cellular response to protein unfolding stress (2007)
Book Chapter
Schröder, M. (2007). The cellular response to protein unfolding stress. In G. Robson, P. van West, & G. Gadd (Eds.), BMS Symposium Series, Exploitation of Fungi (117-139). Cambridge University Press

Recent advances in understanding the unfolded protein response (2007)
Journal Article
Schröder, M., & Kohno, K. (2007). Recent advances in understanding the unfolded protein response. Antioxidants and Redox Signaling, 9(12), 2241-2244. https://doi.org/10.1089/ars.2007.1877