All Outputs (14)

Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis (2024)
Journal Article
Acton, O. J., Sheppard, D., Kunzelmann, S., Caswell, S. J., Nans, A., Burgess, A. J. O., …Taylor, I. A. (2024). Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis. Nature Communications, 15(1), Article 3775. https://doi.org/10.1038/s41467-024-48237-w

SAMHD1 regulates cellular nucleotide homeostasis, controlling dNTP levels by catalysing their hydrolysis into 2’-deoxynucleosides and triphosphate. In differentiated CD4+ macrophage and resting T-cells SAMHD1 activity results in the inhibition of HIV... Read More about Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis.

Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells (2023)
Journal Article
Tsai, M. C., Caswell, S. J., Morris, E. R., Mann, M. C., Pennell, S., Kelly, G., …Bishop, K. N. (2023). Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells. Retrovirology, 20(1), Article 5. https://doi.org/10.1186/s12977-023-00620-z

SAMHD1 is a deoxynucleotide triphosphohydrolase that restricts replication of HIV-1 in differentiated leucocytes. HIV-1 is not restricted in cycling cells and it has been proposed that this is due to phosphorylation of SAMHD1 at T592 in these cells i... Read More about Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells.

Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of Rp-and Sp-dNTPαS Diastereomers (2021)
Journal Article
Morris, E., Kunzelmann, S., Caswell, S., Purkiss, A., Kelly, G., & Taylor, I. (2021). Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of Rp-and Sp-dNTPαS Diastereomers. Biochemistry, 60(21), 1682-1698. https://doi.org/10.1021/acs.biochem.0c00944

Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis (2020)
Journal Article
Morris, E., Caswell, S., Kunzelmann, S., Arnold, L., Purkiss, A., Kelly, G., & Taylor, I. (2020). Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis. Nature Communications, 11(1), https://doi.org/10.1038/s41467-020-16983-2

Positive selection in dNTPase SAMHD1 throughout mammalian evolution (2019)
Journal Article
Monit, C., Morris, E., Ruis, C., Szafran, B., Thiltgen, G., Tsai, M., …Goldstein, R. (2019). Positive selection in dNTPase SAMHD1 throughout mammalian evolution. Proceedings of the National Academy of Sciences, 116(37), 18647-18654. https://doi.org/10.1073/pnas.1908755116

The missing link: Allostery and catalysis in the anti-viral protein SAMHD1 (2019)
Journal Article
Morris, E., & Taylor, I. (2019). The missing link: Allostery and catalysis in the anti-viral protein SAMHD1. Biochemical Society Transactions, 47(4), 1013-1027. https://doi.org/10.1042/bst20180348

Structural basis for DNA 3′-end processing by human tyrosyl-DNA phosphodiesterase 1 (2018)
Journal Article
Flett, F., Ruksenaite, E., Armstrong, L., Bharati, S., Carloni, R., Morris, E., …Richardson, J. (2018). Structural basis for DNA 3′-end processing by human tyrosyl-DNA phosphodiesterase 1. Nature Communications, 9(1), https://doi.org/10.1038/s41467-017-02530-z

A bend, flip and trap mechanism for transposon integration (2016)
Journal Article
Morris, E., Grey, H., McKenzie, G., Jones, A., & Richardson, J. (2016). A bend, flip and trap mechanism for transposon integration. eLife, 5(MAY2016), https://doi.org/10.7554/elife.15537

A sequence-based approach for prediction of CsrA/RsmA targets in bacteria with experimental validation in Pseudomonas aeruginosa (2014)
Journal Article
Kulkarni, P., Jia, T., Kuehne, S., Kerkering, T., Morris, E., Searle, M., …Kulkarni, R. (2014). A sequence-based approach for prediction of CsrA/RsmA targets in bacteria with experimental validation in Pseudomonas aeruginosa. Nucleic Acids Research, 42(11), 6811-6825. https://doi.org/10.1093/nar/gku309

Biochemical characterization and comparison of two closely related active mariner transposases (2014)
Journal Article
Trubitsyna, M., Morris, E., Finnegan, D., & Richardson, J. (2014). Biochemical characterization and comparison of two closely related active mariner transposases. Biochemistry, 53(4), 682-689. https://doi.org/10.1021/bi401193w

Structural basis of Mos1 transposase inhibition by the anti-retroviral drug raltegravir (2014)
Journal Article
Wolkowicz, U., Morris, E., Robson, M., Trubitsyna, M., & Richardson, J. (2014). Structural basis of Mos1 transposase inhibition by the anti-retroviral drug raltegravir. ACS Chemical Biology, 9(3), 743-751. https://doi.org/10.1021/cb400791u

Structural rearrangement in an RsmA/CsrA Ortholog of pseudomonas aeruginosa creates a dimeric RNA-binding protein, RsmN (2013)
Journal Article
Morris, E., Hall, G., Li, C., Heeb, S., Kulkarni, R., Lovelock, L., …Searle, M. (2013). Structural rearrangement in an RsmA/CsrA Ortholog of pseudomonas aeruginosa creates a dimeric RNA-binding protein, RsmN. Structure, 21(9), 1659-1671. https://doi.org/10.1016/j.str.2013.07.007

Overview of protein folding mechanisms: Experimental and theoretical approaches to probing energy landscapes (2012)
Journal Article
Morris, E., & Searle, M. (2012). Overview of protein folding mechanisms: Experimental and theoretical approaches to probing energy landscapes. https://doi.org/10.1002/0471140864.ps2802s68

Exploring knotting mechanisms in protein folding (2008)
Journal Article
Mallam, A., Morris, E., & Jackson, S. (2008). Exploring knotting mechanisms in protein folding. Proceedings of the National Academy of Sciences, 105(48), 18740-18745. https://doi.org/10.1073/pnas.0806697105