All Outputs (5)

Evaluation of the antibacterial properties of commonly used clays from deposits in central and southern Asia (2024)
Journal Article
Abdullayev, E., Paterson, J. R., Kuszynski, E. P., Hamidi, M. D., Nahar, P., Greenwell, H. C., Neumann, A., & Sharples, G. J. (2024). Evaluation of the antibacterial properties of commonly used clays from deposits in central and southern Asia. Clays and Clay Minerals, 72, Article e9. https://doi.org/10.1017/cmn.2024.7

One potential solution to the rising threat of antibacterial drug resistance is the application of therapeutic clays to treat wound infections. Clays with antibacterial activity have been identified from a range of sources with their antibacterial pr... Read More about Evaluation of the antibacterial properties of commonly used clays from deposits in central and southern Asia.

A critical role for iron and zinc homeostatic systems in the evolutionary adaptation of Escherichia coli to metal restriction (2023)
Journal Article
Paterson, J. R., Wadsworth, J. M., Hu, P., & Sharples, G. J. (2023). A critical role for iron and zinc homeostatic systems in the evolutionary adaptation of Escherichia coli to metal restriction. Microbial Genomics, 9(12), Article 001153. https://doi.org/10.1099/mgen.0.001153

Host nutritional immunity utilizes metal deprivation to help prevent microbial infection. To investigate bacterial adaptation to such restrictive conditions, we conducted experimental evolution with two metal sequestering agents. Ethylenediaminetetra... Read More about A critical role for iron and zinc homeostatic systems in the evolutionary adaptation of Escherichia coli to metal restriction.

Insights into the antibacterial mechanism of action of chelating agents by selective deprivation of iron, manganese and zinc (2021)
Journal Article
Paterson, J. R., Beecroft, M. S., Mulla, R. S., Osman, D., Reeder, N. L., Caserta, J. A., Young, T. R., Pettigrew, C. A., Davies, G. E., Williams, J. G., & Sharples, G. J. (2022). Insights into the antibacterial mechanism of action of chelating agents by selective deprivation of iron, manganese and zinc. Applied and Environmental Microbiology, 88(2), Article e01641-21. https://doi.org/10.1128/aem.01641-21

Bacterial growth and proliferation can be restricted by limiting the availability of metal ions in their environment. Humans sequester iron, manganese and zinc to help prevent infection by pathogens, a system termed nutritional immunity. Commercially... Read More about Insights into the antibacterial mechanism of action of chelating agents by selective deprivation of iron, manganese and zinc.

Bioinspired and eco-friendly high efficacy cinnamaldehyde antibacterial surfaces (2021)
Journal Article
Cox, H. J., Li, J., Saini, P., Paterson, J. R., Sharples, G. J., & Badyal, J. P. S. (2021). Bioinspired and eco-friendly high efficacy cinnamaldehyde antibacterial surfaces. Journal of Materials Chemistry B: Materials for biology and medicine, 9(12), 2918-2930. https://doi.org/10.1039/d0tb02379e

Antimicrobial essential oils are incorporated into mussel-inspired and natural plant polyphenol coatings as part of a single-step fabrication process. Polydopamine–cinnamaldehyde, polyethyleneimine–cinnamaldehyde, and tannic acid–cinnamaldehyde coati... Read More about Bioinspired and eco-friendly high efficacy cinnamaldehyde antibacterial surfaces.

A bacteriophage mimic of the bacterial nucleoid-associated protein Fis (2020)
Journal Article
Sharples, G. J., Heddle, J. G., Kozak, M., Taube, M., Hughes, T. R., Pålsson, L.-O., Bowers, L. Y., Curtis, F. A., Plewka, J., Świątek, S., Paterson, J. R., Jolma, A., Yang, A. W. H., Gittens, W. H., Trotter, A. J., Balakrishnan, D., & Chakraborti, S. (2020). A bacteriophage mimic of the bacterial nucleoid-associated protein Fis. Biochemical Journal, 477(7), 1345-1362. https://doi.org/10.1042/bcj20200146

We report the identification and characterization of a bacteriophage λ-encoded protein, NinH. Sequence homology suggests similarity between NinH and Fis, a bacterial nucleoid-associated protein involved in numerous DNA topology manipulations, includi... Read More about A bacteriophage mimic of the bacterial nucleoid-associated protein Fis.