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The Synergistic Action of Melittin and Phospholipase A2 with Lipid Membranes: Development of Linear Dichroism for Membrane-Insertion Kinetics (2010)
Journal Article
Damianoglou, A., Rodger, A., Pridmore, C., Dafforn, T. R., Mosely, J. A., Sanderson, J. M., & Hicks, M. R. (2010). The Synergistic Action of Melittin and Phospholipase A2 with Lipid Membranes: Development of Linear Dichroism for Membrane-Insertion Kinetics. Protein and Peptide Letters, 17(11), 1351-1362. https://doi.org/10.2174/0929866511009011351

Here we present data on the kinetics of insertion of melittin, a peptide from bee venom, into lipid membranes of different composition. Another component of bee venom is the enzyme phospholipase A2 (PLA₂). We have examined the interaction of melittin... Read More about The Synergistic Action of Melittin and Phospholipase A2 with Lipid Membranes: Development of Linear Dichroism for Membrane-Insertion Kinetics.

Free-Energy Relationships for the Interactions of Tryptophan with Phosphocholines (2009)
Journal Article
Blaser, G., Sanderson, J. M., & Wilson, M. R. (2009). Free-Energy Relationships for the Interactions of Tryptophan with Phosphocholines. Organic and Biomolecular Chemistry, 7(24), 5119-5128. https://doi.org/10.1039/b913919b

In membrane proteins and peptides, tryptophan exhibits a marked tendency to occur in locations that correspond to the interfacial region of the lipid bilayer. The relative contributions of electrostatic, dipolar, hydrophobic and conformational effect... Read More about Free-Energy Relationships for the Interactions of Tryptophan with Phosphocholines.

Surface features of a Mononegavirales matrix protein indicate sites of membrane interaction (2009)
Journal Article
Money, V., McPhee, H., Mosely, J., Sanderson, J., & Yeo, R. (2009). Surface features of a Mononegavirales matrix protein indicate sites of membrane interaction. Proceedings of the National Academy of Sciences, 106(11), 4441-4446. https://doi.org/10.1073/pnas.0805740106

The matrix protein (M) of respiratory syncytial virus (RSV), the prototype viral member of the Pneumovirinae (family Paramyxoviridae, order Mononegavirales), has been crystallized and the structure determined to a resolution of 1.6 A. The structure c... Read More about Surface features of a Mononegavirales matrix protein indicate sites of membrane interaction.

Peptide Adsorption to Lipid Bilayers: Slow Processes Revealed by Linear Dichroism Spectroscopy (2009)
Journal Article
Ennaceur, S. M., Hicks, M. R., Pridmore, C. J., Dafforn, T. R., Rodger, A., & Sanderson, J. M. (2009). Peptide Adsorption to Lipid Bilayers: Slow Processes Revealed by Linear Dichroism Spectroscopy. Biophysical Journal, 96(4), 1399-1407. https://doi.org/10.1016/j.bpj.2008.10.039

The adsorption and insertion kinetics for the association of two 34-residue cyclic peptides with phosphocholine membranes have been studied using circular and linear dichroism approaches. The two peptides studied are identical with the exception of t... Read More about Peptide Adsorption to Lipid Bilayers: Slow Processes Revealed by Linear Dichroism Spectroscopy.

The Facile Synthesis of a Series of Tryptophan Derivatives (2008)
Journal Article
Blaser, G., Sanderson, J., Batsanov, A., & Howard, J. (2008). The Facile Synthesis of a Series of Tryptophan Derivatives. Tetrahedron Letters, 49(17), 2795-2798. https://doi.org/10.1016/j.tetlet.2008.02.120

This study reports a facile method for the synthesis of a variety of 5- and 6-substituted tryptophan derivatives that are difficult to prepare using alternative enzymatic approaches. Acylation of an activated amino acid, derived from serine in situ,... Read More about The Facile Synthesis of a Series of Tryptophan Derivatives.

A Gramicidin Analogue that Exhibits Redox Potential Dependent Cation Influx (2007)
Journal Article
Jackson, T., Sanderson, J., & Kataky, R. (2008). A Gramicidin Analogue that Exhibits Redox Potential Dependent Cation Influx. Sensors and Actuators B: Chemical, 130(2), 630-637. https://doi.org/10.1016/j.snb.2007.10.019

A synthetic analogue of gramicidin A, gram-2-(nicotinamidyl)ethyl carbamate (gAN) was found to regulate the influx of potassium ions depending on its redox state. At potentials less than −0.52 (±0.05) V, the nicotinamide group in gAN is reduced and a... Read More about A Gramicidin Analogue that Exhibits Redox Potential Dependent Cation Influx.

Refined models for the preferential interactions of tryptophan with phosphocholines (2007)
Journal Article
Sanderson, J. (2007). Refined models for the preferential interactions of tryptophan with phosphocholines. Organic and Biomolecular Chemistry, 5(20), 3276- 3286. https://doi.org/10.1039/b707502b

series of molecular models of the adducts formed between N-acetyl-L-tryptophan ethylamide and diacetyl-sn-glycero-3-phosphocholine have been generated. Using rOesy data that enabled us to place restrictions on the proximity of a number of key protons... Read More about Refined models for the preferential interactions of tryptophan with phosphocholines.

Preparation of Novel 3H-Trifluoromethyldiazirine-Based Photoactivatable Potassium Channel Antagonists. (2005)
Journal Article
Sanderson, J., Findlay, J., & Fishwick, C. (2005). Preparation of Novel 3H-Trifluoromethyldiazirine-Based Photoactivatable Potassium Channel Antagonists. Tetrahedron, 61(47), 11244-11252. https://doi.org/10.1016/j.tet.2005.09.007

The preparation of a series of photoactivatable precursors for use in photoaffinity labelling of potassium channels is described. 3H-Diazirine functionalities were incorporated into the previously described potassium channel antagonists 1-3. The abil... Read More about Preparation of Novel 3H-Trifluoromethyldiazirine-Based Photoactivatable Potassium Channel Antagonists..

Peptide-lipid interactions: insights and perspectives (2005)
Journal Article
Sanderson, J. (2005). Peptide-lipid interactions: insights and perspectives. Organic and Biomolecular Chemistry, 3(2), 201-212. https://doi.org/10.1039/b415499a

As the number of membrane proteins in the Protein Data Bank increases, efforts to understand how they interact with their natural environment are increasing in importance. A number of membrane proteins crystallise with lipid molecules implicitly boun... Read More about Peptide-lipid interactions: insights and perspectives.

Well Defined Bioactive Polymers by RAFT Polymerization. (2005)
Journal Article
Cameron, N., Spain, S., Bayley, J., Watson, H., Dureault, A., Sanderson, J., …van Hest, J. (2005). Well Defined Bioactive Polymers by RAFT Polymerization. Abstracts of papers - American Chemical Society, 230, U4302-U4302

Micellar aggregates formed following the addition of hexafluoroisopropanol to phospholipid membranes (2005)
Journal Article
Ennaceur, S., & Sanderson, J. (2005). Micellar aggregates formed following the addition of hexafluoroisopropanol to phospholipid membranes. Langmuir, 21(2), 552-561. https://doi.org/10.1021/la048109y

The addition of 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) to aqueous phospholipid membranes leads to perturbation of the bilayer. In the case of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), calorimetric and small-angle X-ray scattering analyses... Read More about Micellar aggregates formed following the addition of hexafluoroisopropanol to phospholipid membranes.

Characterisation of the Interactions of Aromatic Amino Acids with Diacetyl Phosphatidylcholine (2004)
Journal Article
Sanderson, J., & Whelan, E. (2004). Characterisation of the Interactions of Aromatic Amino Acids with Diacetyl Phosphatidylcholine. Physical Chemistry Chemical Physics, 6(5), 1012-1017. https://doi.org/10.1039/b312184d

A simple bimolecular system for characterising the interactions of amino acids with diacyl-3-phosphatidylcholines has been developed. The system contains two components: an N-acetyl amino acid N'-alkyl amide and diacetyl-3-sn-phosphatidylcholine (DAP... Read More about Characterisation of the Interactions of Aromatic Amino Acids with Diacetyl Phosphatidylcholine.

The Synthesis of Peptides and Proteins Containing Non-Natural Amino Acids (2004)
Journal Article
Hodgson, D., & Sanderson, J. (2004). The Synthesis of Peptides and Proteins Containing Non-Natural Amino Acids. Chemical Society Reviews, 33(7), 422-430. https://doi.org/10.1039/b312953p

Methods for the incorporation of non-natural amino acids into proteins have advanced significantly over recent years and in this tutorial review we aim to give a general overview of the area. These techniques offer the possibility of modulating the s... Read More about The Synthesis of Peptides and Proteins Containing Non-Natural Amino Acids.

Analysis of Liposomal Membrane Composition Using Raman Tweezers (2004)
Journal Article
Sanderson, J., & Ward, A. (2004). Analysis of Liposomal Membrane Composition Using Raman Tweezers. Chemical Communications, 1120-1121. https://doi.org/10.1039/b316757g

We have developed a methodology for the analysis of liposomal membranes and their contents using near-IR Raman spectroscopy on liposomes held in an optical trap. We were able to detect a variety of membrane components including lipids, cholesterol, a... Read More about Analysis of Liposomal Membrane Composition Using Raman Tweezers.

Selective Adhesion, Lipid Exchange and Membrane-Fusion Processes Between Vesicles of Various Sizes Bearing Complementary Molecular Recognition Groups. (2001)
Journal Article
Marchi-Artzner, V., T. Gulik-Krzywicki, T., Guedeau-Boudeville, M., Gosse, C., Sanderson, J., Dedieu, J., & Lehn, J. (2001). Selective Adhesion, Lipid Exchange and Membrane-Fusion Processes Between Vesicles of Various Sizes Bearing Complementary Molecular Recognition Groups. ChemPhysChem, 2(6), 367-376. https://doi.org/10.1002/1439-7641%2820010618%292%3A6%3C367%3A%3Aaid-cphc367%3E3.0.co%3B2-%23

A Supramolecular System for Quantifying Aromatic Stacking Interactions. (2001)
Journal Article
Adams, H., Hunter, C., Lawson, K., Perkins, J., Spey, S., Urch, C., & Sanderson, J. (2001). A Supramolecular System for Quantifying Aromatic Stacking Interactions. Chemistry - A European Journal, 7(22), 4863-4877. https://doi.org/10.1002/1521-3765%2820011119%297%3A22%3C4863%3A%3Aaid-chem4863%3E3.0.co%3B2-3

A supramolecular complex for investigating the thermodynamic properties of intermolecular aromatic stacking interactions has been developed. The conformation of the complex is locked in a single well-defined conformation by an array of H-bonding inte... Read More about A Supramolecular System for Quantifying Aromatic Stacking Interactions..

The synthesis and reactivity of optically pure amino acids bearingside-chain thioamides (2000)
Journal Article
Sanderson, J., Singh, P., Fishwick, C., & Findlay, J. (2000). The synthesis and reactivity of optically pure amino acids bearingside-chain thioamides. Perkin 1, 3227-3231. https://doi.org/10.1039/b004688o

The synthesis and reactivity of fully protected thioamide analogues of asparagine: and glutamine are described. A key feature of the synthetic strategies employed was the ability to perform selective thiations on multiple carbonyl-containing substrat... Read More about The synthesis and reactivity of optically pure amino acids bearingside-chain thioamides.