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The atypical ‘hippocampal’ glutamate receptor coupled to phospholipase D that controls stretch‐sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2 (2023)
Journal Article
Thompson, K. J., Watson, S., Zanato, C., Dall'Angelo, S., De Nooij, J. C., Pace‐Bonello, B., …Bewick, G. S. (2024). The atypical ‘hippocampal’ glutamate receptor coupled to phospholipase D that controls stretch‐sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2. Experimental Physiology, 109(1), 81-99. https://doi.org/10.1113/ep090761

A metabotropic glutamate receptor coupled to phospholipase D (PLD-mGluR) was discovered in the hippocampus over three decades ago. Its pharmacology and direct linkage to PLD activation are well established and indicate it is a highly atypical glutama... Read More about The atypical ‘hippocampal’ glutamate receptor coupled to phospholipase D that controls stretch‐sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2.

The durability, functionality and acceptability of novel screened doors and windows after 4 years of use in a Gambian village: a cross-sectional survey (2022)
Journal Article
Shenton, F. C., Jawara, M., Carrasco-Tenezaca, M., Knudsen, J., D’Alessandro, U., & Lindsay, S. W. (2022). The durability, functionality and acceptability of novel screened doors and windows after 4 years of use in a Gambian village: a cross-sectional survey. Malaria Journal, 21(1), https://doi.org/10.1186/s12936-022-04087-9

Background The World Health Organization recommends house screening as a tool for malaria control, yet evidence of the long-term durability, functionality and acceptability of this intervention is lacking. In this study, the sustainability and use of... Read More about The durability, functionality and acceptability of novel screened doors and windows after 4 years of use in a Gambian village: a cross-sectional survey.

Preventing yellow fever epidemics in Asian megacities: how can cities control mosquito-transmitted diseases? (2021)
Journal Article
Shenton, F. C., & Lindsay, S. W. (2023). Preventing yellow fever epidemics in Asian megacities: how can cities control mosquito-transmitted diseases?. Cities and Health, 7(3), 335-341. https://doi.org/10.1080/23748834.2021.1899486

The COVID-19 pandemic has reminded us of the ever present threat from infectious diseases, this includes the ones we know about already and future unknowns. The mosquito-transmitted disease yellow fever has claimed thousands of lives over the centuri... Read More about Preventing yellow fever epidemics in Asian megacities: how can cities control mosquito-transmitted diseases?.

Recommendations for building out mosquito-transmitted diseases in sub-Saharan Africa: the DELIVER mnemonic (2020)
Journal Article
Lindsay, S. W., Davies, M., Alabaster, G., Altamirano, H., Jatta, E., Jawara, M., Carrasco-Tenezaca, M., von Seidlein, L., Shenton, F. C., Tusting, L. S., Wilson, A. L., & Knudsen, J. (2021). Recommendations for building out mosquito-transmitted diseases in sub-Saharan Africa: the DELIVER mnemonic. Philosophical Transactions of the Royal Society B: Biological Sciences, 376(1818), Article 20190814. https://doi.org/10.1098/rstb.2019.0814

In sub-Saharan Africa, most transmission of mosquito-transmitted diseases, such as malaria or dengue, occurs within or around houses. Preventing mosquito house entry and reducing mosquito production around the home would help reduce the transmission... Read More about Recommendations for building out mosquito-transmitted diseases in sub-Saharan Africa: the DELIVER mnemonic.

Electrophysiological characterisation of atrial volume receptors using ex‐vivo models of isolated rat cardiac atria (2020)
Journal Article
Campbell, T., Shenton, F., Lucking, E., Pyner, S., & Jones, J. (2020). Electrophysiological characterisation of atrial volume receptors using ex‐vivo models of isolated rat cardiac atria. Experimental Physiology, 105(12), 2190-2206. https://doi.org/10.1113/ep088972

Atrial volume receptors are a family of afferent neurons whose mechanically sensitive endings terminate in the atria, particularly at the cavo‐atrial junctions. These mechanosensors form the afferent limb of an atrial volume receptor reflex which reg... Read More about Electrophysiological characterisation of atrial volume receptors using ex‐vivo models of isolated rat cardiac atria.

Distribution and morphology of sensory and autonomic fibres in the subendocardial plexus of the rat heart (2020)
Journal Article
Shenton, F., Campbell, T., Jones, J., & Pyner, S. (2020). Distribution and morphology of sensory and autonomic fibres in the subendocardial plexus of the rat heart. Journal of Anatomy, 238(1), 36-52. https://doi.org/10.1111/joa.13284

Cardiac reflexes originating from sensory receptors in the heart ensure blood supply to vital tissues and organs in the face of constantly changing demands. Atrial volume receptors are mechanically sensitive vagal afferents which relay to the medulla... Read More about Distribution and morphology of sensory and autonomic fibres in the subendocardial plexus of the rat heart.

Research agenda for preventing mosquito-transmitted diseases through improving the built environment in sub-Saharan Africa (2019)
Journal Article
Shenton, F. C., Addissie, A., Alabaster, G., Baziwe, D., Carrasco Tenezaca, M., Chinula, D., Jatta, E., Jawara, M., Jones, R., Knudsen, J., Krystosik, A. R., McCann, R., Murima, N., Mutuku, F., Nguela, R. L., Nieto Sanchez, C., Nix, E., Okumu, F., Ruel-Bergeron, S., Spitzen, J., …Lindsay, S. W. (2022). Research agenda for preventing mosquito-transmitted diseases through improving the built environment in sub-Saharan Africa. Cities and Health, 6(1), 72-80. https://doi.org/10.1080/23748834.2019.1684771

Mosquito-transmitted diseases are a major threat to health in sub-Saharan Africa, but could be reduced through modifications to the built environment. Here we report findings from a major workshop held to identify the research gaps in this area, name... Read More about Research agenda for preventing mosquito-transmitted diseases through improving the built environment in sub-Saharan Africa.

Transient receptor potential vanilloid type 4 is expressed in vasopressinergic neurons within the magnocellular subdivision of the rat paraventricular nucleus of the hypothalamus (2018)
Journal Article
Shenton, F., & Pyner, S. (2018). Transient receptor potential vanilloid type 4 is expressed in vasopressinergic neurons within the magnocellular subdivision of the rat paraventricular nucleus of the hypothalamus. Journal of Comparative Neurology, 526(18), 3035-3044. https://doi.org/10.1002/cne.24514

Changes in plasma osmolality can drive changes in the output from brain centres known to control cardiovascular homeostasis, such as the paraventricular nucleus of the hypothalamus (PVN). Within the PVN hypotonicity reduces the firing rate of parvoce... Read More about Transient receptor potential vanilloid type 4 is expressed in vasopressinergic neurons within the magnocellular subdivision of the rat paraventricular nucleus of the hypothalamus.

Vagal Afferents, Sympathetic Efferents and the Role of the PVN in Heart Failure (2016)
Journal Article
Shenton, F., & Pyner, S. (2016). Vagal Afferents, Sympathetic Efferents and the Role of the PVN in Heart Failure. Autonomic Neuroscience: Basic and Clinical, 199, 38-47. https://doi.org/10.1016/j.autneu.2016.08.009

Sympatho-excitation is a characteristic of cardiovascular disease including heart failure (HF). The paraventricular nucleus of the hypothalamus (PVN) is an important site for central integration of sympathetic outflow. Atrial volume receptors (AVRs)... Read More about Vagal Afferents, Sympathetic Efferents and the Role of the PVN in Heart Failure.

Graphene oxide nanocapsules within silanized hydrogels suitable for electrochemical pseudocapacitors (2015)
Journal Article
Kataky, R., Hadden, J., Coleman, K., Ntola, C., Chowdhury, M., Duckworth, A., …Shenton, F. (2015). Graphene oxide nanocapsules within silanized hydrogels suitable for electrochemical pseudocapacitors. Chemical Communications, 51(51), 10345-10348. https://doi.org/10.1039/c5cc00968e

Soft biocompatible gels comprised of rolled up graphene oxide nanocapsules within the pores of silanized hydrogels may be used as electrochemical pseudocapacitors with physiological glucose or KOH as a reducing agent, affording a material suitable fo... Read More about Graphene oxide nanocapsules within silanized hydrogels suitable for electrochemical pseudocapacitors.

A study of the expression of small conductance calcium-activated potassium channels (SK1-3) in sensory endings of muscle spindles and lanceolate endings of hair follicles in the rat (2014)
Journal Article
Shenton, F., Bewick, G., & Banks, R. (2014). A study of the expression of small conductance calcium-activated potassium channels (SK1-3) in sensory endings of muscle spindles and lanceolate endings of hair follicles in the rat. PLoS ONE, 9(9), https://doi.org/10.1371/journal.pone.0107073

Processes underlying mechanotransduction and its regulation are poorly understood. Inhibitors of Ca2+-activated K+ channels cause a dramatic increase in afferent output from stretched muscle spindles. We used immunocytochemistry to test for the prese... Read More about A study of the expression of small conductance calcium-activated potassium channels (SK1-3) in sensory endings of muscle spindles and lanceolate endings of hair follicles in the rat.

Expression of Transient Receptor Potential channels TRPC1 and TRPV4 in venoatrial endocardium of the rat heart (2014)
Journal Article
Shenton, F., & Pyner, S. (2014). Expression of Transient Receptor Potential channels TRPC1 and TRPV4 in venoatrial endocardium of the rat heart. Neuroscience, 267, 195-204. https://doi.org/10.1016/j.neuroscience.2014.02.047

The atrial volume receptor reflex arc serves to regulate plasma volume. Atrial volume receptors located in the endocardium of the atrial wall undergo mechanical deformation as blood is returned to the atria of the heart. The mechanosensitive channel(... Read More about Expression of Transient Receptor Potential channels TRPC1 and TRPV4 in venoatrial endocardium of the rat heart.

Glutamatergic modulation of synaptic-like vesicle recycling in mechanosensory lanceolate nerve terminals of mammalian hair follicles (2013)
Journal Article
Banks, R. W., Cahusac, P. M., Graca, A., Kain, N., Shenton, F., Singh, P., …Bewick, G. S. (2013). Glutamatergic modulation of synaptic-like vesicle recycling in mechanosensory lanceolate nerve terminals of mammalian hair follicles. The Journal of Physiology, 591(10), 2523-2540. https://doi.org/10.1113/jphysiol.2012.243659

Our aim in the present study was to determine whether a glutamatergic modulatory system involving synaptic-like vesicles (SLVs) is present in the lanceolate ending of the mouse and rat hair follicle and, if so, to assess its similarity to that of the... Read More about Glutamatergic modulation of synaptic-like vesicle recycling in mechanosensory lanceolate nerve terminals of mammalian hair follicles.

Amiloride-sensitive channels are a major contributor to mechanotransduction in mammalian muscle spindles. (2010)
Journal Article
Simon, A., Shenton, F., Hunter, I., Banks, R. W., & Bewick, G. S. (2010). Amiloride-sensitive channels are a major contributor to mechanotransduction in mammalian muscle spindles. The Journal of Physiology, 588(1), 171-185. https://doi.org/10.1113/jphysiol.2009.182683

We investigated whether channels of the epithelial sodium/amiloride-sensitive degenerin(ENaC/DEG) family are a major contributor to mechanosensory transduction in primary mechanosensory afferents, using adult rat muscle spindles as a model system. St... Read More about Amiloride-sensitive channels are a major contributor to mechanotransduction in mammalian muscle spindles..

Oligomerization of recombinant and endogenously expressed human histamine H4 receptors (2006)
Journal Article
Van Rijn, R., Chazot, P., Shenton, F., Sansuk, K., Bakker, R., & Leurs, R. (2006). Oligomerization of recombinant and endogenously expressed human histamine H4 receptors. Molecular Pharmacology, 70(2), 604-615. https://doi.org/10.1124/mol.105.020818

In this study, we report the homo- and hetero-oligomerization of the human histamine H4R by both biochemical (Western blot and immobilized metal affinity chromatography) and biophysical [bioluminescence resonance energy transfer and time-resolved flu... Read More about Oligomerization of recombinant and endogenously expressed human histamine H4 receptors.