Novel antibiotics: C-2 symmetrical macrocycles inhibiting Holliday junction DNA binding by E. coli RuvC.

Pan, P.-S.; Curtis, F.A.; Carroll, C.L.; Medina, I.; Rodrigeuz, R.; Liotta, L.A.; Sharples, G.J.; McAlpine, S.R.

doi:10.1016/j.bmc.2006.03.028

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Novel antibiotics: C-2 symmetrical macrocycles inhibiting Holliday junction DNA binding by E. coli RuvC. (2006)
Journal Article
Pan, P., Curtis, F., Carroll, C., Medina, I., Rodrigeuz, R., Liotta, L., …McAlpine, S. (2006). Novel antibiotics: C-2 symmetrical macrocycles inhibiting Holliday junction DNA binding by E. coli RuvC. Bioorganic and Medicinal Chemistry, 14(14), 4731-4739. https://doi.org/10.1016/j.bmc.2006.03.028

Holliday junctions (HJs) are formed as transient DNA intermediates during site-specific and homologous recombination. Both of these genetic exchange pathways are critical for normal DNA metabolism and repair. Trapping HJs leads to bacterial cell deat... Read More about Novel antibiotics: C-2 symmetrical macrocycles inhibiting Holliday junction DNA binding by E. coli RuvC..