The anti-inflammatory drug mesalamine targets bacterial polyphosphate accumulation

Dahl, J.-U.; Gray, M.J.; Bazopoulou, D.; Beaufay, F.; Lempart, J.; Koenigsknecht, M.J.; Wang, Y.; Baker, J.R.; Hasler, W.L.; Young, V.B.; Sun, D.; Jakob, U.

doi:10.1038/nmicrobiol.2016.267

All Outputs (2)

Developmental ROS individualizes organismal stress resistance and lifespan (2019)
Journal Article
Bazopoulou, D., Knoefler, D., Zheng, Y., Ulrich, K., Oleson, B., Xie, L., Kim, M., Kaufmann, A., Lee, Y.-T., Dou, Y., Chen, Y., Quan, S., & Jakob, U. (2019). Developmental ROS individualizes organismal stress resistance and lifespan. Nature, 576(7786), 301-305. https://doi.org/10.1038/s41586-019-1814-y

A central aspect of aging research concerns the question of when individuality in lifespan arises. Here we show that a transient increase in reactive oxygen species (ROS), which occurs naturally during early development in a subpopulation of synchron... Read More about Developmental ROS individualizes organismal stress resistance and lifespan.

The anti-inflammatory drug mesalamine targets bacterial polyphosphate accumulation (2017)
Journal Article
Dahl, J.-U., Gray, M., Bazopoulou, D., Beaufay, F., Lempart, J., Koenigsknecht, M., Wang, Y., Baker, J., Hasler, W., Young, V., Sun, D., & Jakob, U. (2017). The anti-inflammatory drug mesalamine targets bacterial polyphosphate accumulation. Nature Microbiology, 2, Article 16267. https://doi.org/10.1038/nmicrobiol.2016.267

Mesalamine serves as the gold standard in treating ulcerative colitis. However, its precise mechanism(s) of action remains unclear. Here, we show that mesalamine treatment rapidly decreases polyphosphate levels in diverse bacteria, including members... Read More about The anti-inflammatory drug mesalamine targets bacterial polyphosphate accumulation.