Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle
(2001)
Journal Article
Rosenberg, M., Velarde, G., Ford, R., Martin, C., Berridge, G., Kerr, I., …Higgins, C. (2001). Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle. The EMBO Journal, 20(20), 5615-5625. https://doi.org/10.1093/emboj/20.20.5615
P-glycoprotein (P-gp) is an ABC (ATP-binding cassette) transporter, which hydrolyses ATP and extrudes cytotoxic drugs from mammalian cells. P-gp consists of two transmembrane domains (TMDs) that span the membrane multiple times, and two cytoplasmic n... Read More about Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle.