All Outputs (3)

Shape-Morphing of an Artificial Protein Cage with Unusual Geometry Induced by a Single Amino Acid Change (2022)
Journal Article
Sharma, M., Biela, A. P., Kowalczyk, A., Borzęcka-Solarz, K., Piette, B. M., Gaweł, S., …Heddle, J. G. (2022). Shape-Morphing of an Artificial Protein Cage with Unusual Geometry Induced by a Single Amino Acid Change. ACS Nanoscience Au, 2(5), 404-413. https://doi.org/10.1021/acsnanoscienceau.2c00019

Artificial protein cages are constructed from multiple protein subunits. The interaction between the subunits, notably the angle formed between them, controls the geometry of the resulting cage. Here, using the artificial protein cage, “TRAP-cage”, w... Read More about Shape-Morphing of an Artificial Protein Cage with Unusual Geometry Induced by a Single Amino Acid Change.

Characterization of near-miss connectivity-invariant homogeneous convex polyhedral cages (2022)
Journal Article
Piette, B. M., Kowalczyk, A., & Heddle, J. G. (2022). Characterization of near-miss connectivity-invariant homogeneous convex polyhedral cages. Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, 478(2260), Article 20210679. https://doi.org/10.1098/rspa.2021.0679

Following the discovery of a nearly symmetric protein cage, we introduce the new mathematical concept of a near-miss polyhedral cage (p-cage) as an assembly of nearly regular polygons with holes between them. We then introduce the concept of the conn... Read More about Characterization of near-miss connectivity-invariant homogeneous convex polyhedral cages.

Artificial Protein Cage with Unusual Geometry and Regularly Embedded Gold Nanoparticles (2022)
Journal Article
Majsterkiewicz, K., Biela, A. P., Maity, S., Sharma, M., Piette, B. M., Kowalczyk, A., …Heddle, J. G. (2022). Artificial Protein Cage with Unusual Geometry and Regularly Embedded Gold Nanoparticles. Nano Letters, 22(8), 3187-3195. https://doi.org/10.1021/acs.nanolett.1c04222

Artificial protein cages have great potential in a number of areas including cargo capture and delivery and as artificial vaccines. Here, we investigate an artificial protein cage whose assembly is triggered by gold nanoparticles. Using biochemical a... Read More about Artificial Protein Cage with Unusual Geometry and Regularly Embedded Gold Nanoparticles.