All Outputs (4)

The interplay between hydrogen bonds and stacking/T-type interactions in molecular cocrystals (2024)
Journal Article
Cruz-Cabeza, A., Spackman, P., & Hall, A. (2024). The interplay between hydrogen bonds and stacking/T-type interactions in molecular cocrystals. Communications Chemistry, 7(1), Article 284. https://doi.org/10.1038/s42004-024-01380-3

Supramolecular synthon and hydrogen bond pairing approaches have influenced the understanding of cocrystal formation for decades, but are hydrogen bonds really the dominant interaction in cocrystals? To investigate this, an extensive analysis of 1:1... Read More about The interplay between hydrogen bonds and stacking/T-type interactions in molecular cocrystals.

Rationalizing the Influence of Small-Molecule Dopants on Guanine Crystal Morphology (2024)
Journal Article
Wagner, A., Hill, A., Lemcoff, T., Livne, E., Avtalion, N., Casati, N., Kariuki, B. M., Graber, E. R., Harris, K. D. M., Cruz-Cabeza, A. J., & Palmer, B. A. (2024). Rationalizing the Influence of Small-Molecule Dopants on Guanine Crystal Morphology. Chemistry of Materials, 36(18), 8910–8919. https://doi.org/10.1021/acs.chemmater.4c01771

Many spectacular optical phenomena in animals are produced by reflective assemblies of guanine crystals. The crystals comprise planar H-bonded layers of π-stacked molecules with a high in-plane refractive index. By preferentially expressing the highl... Read More about Rationalizing the Influence of Small-Molecule Dopants on Guanine Crystal Morphology.

What Has Carbamazepine Taught Crystal Engineers? (2024)
Journal Article
Hall, A. V., Cruz-Cabeza, A. J., & Steed, J. W. (2024). What Has Carbamazepine Taught Crystal Engineers?. Crystal Growth and Design, 24(17), 7342-7360. https://doi.org/10.1021/acs.cgd.4c00555

The antiepilepsy drug carbamazepine is one of the most studied pharmaceuticals in the world. The rich story of its solid forms, cocrystals, and formulation is a microcosm of the topical world of pharmaceutical materials. Understanding carbamazepine h... Read More about What Has Carbamazepine Taught Crystal Engineers?.

Crystal size, shape, and conformational changes drive both the disappearance and reappearance of ritonavir polymorphs in the mill. (2024)
Journal Article
Sacchi, P., Wright, S. E., Neoptolemou, P., Lampronti, G. I., Rajagopalan, A. K., Kras, W., …Cruz-Cabeza, A. J. (2024). Crystal size, shape, and conformational changes drive both the disappearance and reappearance of ritonavir polymorphs in the mill. Proceedings of the National Academy of Sciences, 121(15), Article e2319127121. https://doi.org/10.1073/pnas.2319127121

Organic compounds can crystallize in different forms known as polymorphs. Discovery and control of polymorphism is crucial to the pharmaceutical industry since different polymorphs can have significantly different physical properties which impacts th... Read More about Crystal size, shape, and conformational changes drive both the disappearance and reappearance of ritonavir polymorphs in the mill..