The hypoxia response pathway in the Antarctic fish Notothenia coriiceps is functional despite a poly Q/E insertion mutation in HIF-1α.
(2024)
Journal Article
O'Brien, K. M., Rix, A. S., Jasmin, A., & Lavelle, E. (2024). The hypoxia response pathway in the Antarctic fish Notothenia coriiceps is functional despite a poly Q/E insertion mutation in HIF-1α. Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics, 50, Article 101218. https://doi.org/10.1016/j.cbd.2024.101218
Antarctic notothenioid fishes, inhabiting the oxygen-rich Southern Ocean, possess a polyglutamine and glutamic acid (poly Q/E) insertion mutation in the master transcriptional regulator of oxygen homeostasis, hypoxia- inducible factor-1α (HIF-1α). To... Read More about The hypoxia response pathway in the Antarctic fish Notothenia coriiceps is functional despite a poly Q/E insertion mutation in HIF-1α..