S ‐Aryl Substitution Enhances Acidity of the 1,2,4‐Triazolium Scaffold
(2024)
Journal Article
Smith, M. S., Blundell, T. J., Hickson, I., & O'Donoghue, A. C. (2024). S ‐Aryl Substitution Enhances Acidity of the 1,2,4‐Triazolium Scaffold. European Journal of Organic Chemistry, 27(45), Article e202400753. https://doi.org/10.1002/ejoc.202400753
The 1,2,4‐triazolium scaffold in asymmetric organocatalysis results in remarkable rate accelerations, with reactions typically occurring via N‐heterocyclic carbene (NHC) intermediates. Although the most acidic NHC pre‐catalyst class, there remains sc... Read More about S ‐Aryl Substitution Enhances Acidity of the 1,2,4‐Triazolium Scaffold.