C 2 -Symmetric Amino Acid Amide-Derived Organocatalysts
(2024)
Journal Article
Al-Taie, Z. S., Coles, S. J., Congreve, A., Ford, D., Green, L., Horton, P. N., Jones, L. F., Kett, P., Kraehenbuehl, R., Murphy, P. J., Tizzard, G. J., Willmore, N. B., & Wright, O. T. (2024). C 2 -Symmetric Amino Acid Amide-Derived Organocatalysts. Reactions, 5(3), 567-586. https://doi.org/10.3390/reactions5030027
N-alkylated C2-symmetric amino acid amide derivatives were shown to catalyse the Michael addition of 2-hydroxy-1,4-napthoquinone to β-nitrostyrene, achieving a maximum ee of 44%. The corresponding trifluoroacetic acid salts also catalysed the aldol r... Read More about C 2 -Symmetric Amino Acid Amide-Derived Organocatalysts.