Long-wavelength triggered iridium( iii ) complex nanoparticles for photodynamic therapy against hypoxic cancer

Liu, Shengnan; Wang, Ziwei; Wu, Zihan; Chen, Haoran; Zhu, Dongxia; Li, Gungzhe; Yan, Mingming; Bryce, Martin R.; Chang, Yulei

Abstract

A long-wavelength triggered cationic iridium(iii) complex, Ir5, and its corresponding nanoparticles with the ability to generate type I and type II reactive oxygen species have been synthesised. The complex targets mitochondria and achieves an excellent photodynamic therapy effect in hypoxic cancer cells.

Citation

Liu, S., Wang, Z., Wu, Z., Chen, H., Zhu, D., Li, G., Yan, M., Bryce, M. R., & Chang, Y. (2024). Long-wavelength triggered iridium( iii ) complex nanoparticles for photodynamic therapy against hypoxic cancer. Chemical Communications, 60(73), 9938-9941. https://doi.org/10.1039/d4cc03501a

• Journal Article Type: Article
• Acceptance Date: Aug 12, 2024
• Online Publication Date: Aug 22, 2024
• Publication Date: Sep 18, 2024
• Deposit Date: Aug 29, 2024
• Publicly Available Date: Aug 29, 2024
• Journal: Chemical Communications
• Print ISSN: 1359-7345
• Electronic ISSN: 1364-548X
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 60
• Issue: 73
• Pages: 9938-9941
• DOI: https://doi.org/10.1039/d4cc03501a
• Public URL: https://durham-repository.worktribe.com/output/2768086